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All Studies   All Outcomes    Recent:   
0 0.5 1 1.5 2+ Recovery 1% Improvement Relative Risk Viral clearance 3% Symptomatic rebound -171% Viral rebound -52% Paxlovid for COVID-19  Pandit et al.  EARLY TREATMENT Is early treatment with paxlovid beneficial for COVID-19? Prospective study of 170 patients in the USA (Aug - Nov 2022) No significant difference in outcomes seen Pandit et al., medRxiv, November 2022 Favors paxlovid Favors control

The Paxlovid Rebound Study: A Prospective Cohort Study to Evaluate Viral and Symptom Rebound Differences Between Paxlovid and Untreated COVID-19 Participants

Pandit et al., medRxiv, doi:10.1101/2022.11.14.22282195
Nov 2022  
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Prospective study of 170 COVID-19 patients in the USA, showing no significant difference in symptomatic and viral recovery times, and higher risk of symptomatic rebound, without statistical significance. There were more elderly patients in the paxlovid group.
5 paxlovid patients did not test negative during the 16 day daily followup, compared to zero for control. Only patients testing negative or reporting no symptoms were included in the recovery time analyses. KM curves show no significant difference in viral or symptomatic recovery.
risk of no recovery, 1.2% lower, RR 0.99, p = 0.90.
risk of no viral clearance, 2.9% lower, RR 0.97, p = 0.73.
symptomatic rebound, 170.9% higher, RR 2.71, p = 0.06, treatment 24 of 127 (18.9%), control 3 of 43 (7.0%).
viral rebound, 52.4% higher, RR 1.52, p = 0.41, treatment 18 of 127 (14.2%), control 4 of 43 (9.3%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Pandit et al., 15 Nov 2022, prospective, USA, preprint, 8 authors, study period 4 August, 2022 - 1 November, 2022. Contact:
This PaperPaxlovidAll
The Paxlovid Rebound Study: A Prospective Cohort Study to Evaluate Viral and Symptom Rebound Differences Between Paxlovid and Untreated COVID-19 Participants
MD Jay A Pandit, Jennifer M Radin, Danielle Chiang, Emily Spencer, Jeff Pawelek, Mira Diwan, Leila Roumani, Michael Mina
Introduction: The uptake of Paxlovid in individuals infected with COVID-19 has been significantly limited by concerns around the Paxlovid rebound phenomenon despite the scarcity of evidence around its epidemiology. The purpose of this study was to prospectively compare the epidemiology of Paxlovid rebound in treated and untreated participants with acute COVID-19 infection Methods: We designed a decentralized, digital, prospective observational study in which participants who tested positive for COVID-19 using eMed Test-to-Treat telehealth kits and were clinically eligible for Paxlovid were recruited to be evaluated for viral and symptom clearance, as well as rebound. Participants were assigned to a Paxlovid or control group based on their decision to take Paxlovid. Following initial diagnosis based on a telehealth proctored test both groups were provided 12 telehealth proctored rapid antigen home tests and asked to test on a regular frequent schedule for 16 days and answer symptom surveys. Viral rebound based on test results and COVID-19 symptom rebound based on patient reported symptoms were evaluated. Results: Viral rebound incidence was 14.2% in the Paxlovid group (n=127) and 9.3% in the control group (n=43). COVID-19 symptom rebound incidence was higher in the Paxlovid group (18.9%) compared to the control group (7.0%). There were no notable differences in viral rebound by age, gender, pre-existing conditions, or major symptom groups during the acute phase or at the 1-month interval. Conclusion: This preliminary report of our prospective study suggests that rebound after clearance of test positivity or symptom resolution is higher than previously reported. However, we observed a similar rate of rebound in both in the Paxlovid and control groups. Large studies with diverse participants and extended follow-up are needed to better understand the rebound phenomena.
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