Clinical efficacy analysis of paxlovid in children with hematological diseases infected with the omicron SARS-CoV-2 new variant
Yixian Li, Yong Liu, Luping Wen, Hui Chen, Wenqing Wang, Mengyao Tian, Yucai Cheng, Hongman Xue, Chun Chen
Frontiers in Pediatrics, doi:10.3389/fped.2023.1160929
Objective: To summarize the clinical characteristics of children with hematological malignancies co-infected with novel coronavirus and explore the safety and effectiveness of Paxlovid treatment. Methods: From December 10, 2022, to January 20, 2023, the clinical data of children with hematological diseases diagnosed with novel coronavirus infection in the outpatient and emergency department of the Seventh Affiliated Hospital of Sun Yat-sen University were retrospectively analyzed. Results: According to whether to give paxlovid or not, it is divided into group A (paxlovid group) and group B (non-paxlovid group). The length of fever was 1-6 days in group A and 0-3 days in group B. The viral clearance time was shorter in group A than in group B. The inflammatory indexes CRP and PCT were significantly higher in group A than in group B (P < 0.05). Twenty patients were followed up for 1 month after leaving the hospital, and there were 5 cases of reappearance of fever, 1 case of increased sleep, 1 case of physical fatigue and 1 case of loss of appetite within 2 weeks. Conclusions: Paxlovid has no apparent adverse reactions in children 12 years old and younger with underlying hematological diseases infected with the new coronavirus. Focusing on the interaction between paxlovid and other drugs is necessary during the treatment.
Ethics statement The studies involving human participants were reviewed and approved by Ethics Committee of the Seventh Affiliated Hospital of Sun Yat-sen University. Written informed consent to participate in this study was provided by the participants' legal guardian/next of kin. Written informed consent was obtained from the individual(s), and minor(s)' legal guardian/next of kin, for the publication of any potentially identifiable images or data included in this article.
Author contributions CC, HX and YC designed research; YL and YL analyzed data, and wrote the manuscript; LW, HC and WW acquired data, collected clinical data. MT reviewed the data. CC interpreted the data and reviewed the manuscript. All authors contributed to the article and approved the submitted version.
Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
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'abstract': '<jats:sec><jats:title>Objective</jats:title><jats:p>To summarize the clinical characteristics '
'of children with hematological malignancies co-infected with novel coronavirus and explore '
'the safety and effectiveness of Paxlovid '
'treatment.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>From December '
'10, 2022, to January 20, 2023, the clinical data of children with hematological diseases '
'diagnosed with novel coronavirus infection in the outpatient and emergency department of the '
'Seventh Affiliated Hospital of Sun Yat-sen University were retrospectively '
'analyzed.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>According to '
'whether to give paxlovid or not, it is divided into group A (paxlovid group) and group B '
'(non-paxlovid group). The length of fever was 1–6 days in group A and 0–3 days in group B. '
'The viral clearance time was shorter in group A than in group B. The inflammatory indexes CRP '
'and PCT were significantly higher in group A than in group B (<jats:italic>P\u2009'
'</jats:italic>&lt;\u20090.05). Twenty patients were followed up for 1 month after leaving '
'the hospital, and there were 5 cases of reappearance of fever, 1 case of increased sleep, 1 '
'case of physical fatigue and 1 case of loss of appetite within 2 '
'weeks.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Paxlovid has '
'no apparent adverse reactions in children 12 years old and younger with underlying '
'hematological diseases infected with the new coronavirus. Focusing on the interaction between '
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