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0 0.5 1 1.5 2+ NEWS2 score 77% Improvement Relative Risk Oxygen therapy 92% Oxygen time 70% Hospitalization time 13% Viral clearance 10% Curcumin  Hellou et al.  LATE TREATMENT  DB RCT Is late treatment with curcumin + combined treatments beneficial for COVID-19? Double-blind RCT 50 patients in Israel (May - December 2020) Improved recovery (p=0.042) and lower oxygen therapy (p=0.01) Hellou et al., J. Cellular and Molecul.., May 2022 Favors curcumin Favors control

Effect of ArtemiC in patients with COVID-19: A Phase II prospective study

Hellou et al., Journal of Cellular and Molecular Medicine, doi:10.1111/jcmm.17337, NCT04382040
May 2022  
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Curcumin for COVID-19
14th treatment shown to reduce risk in February 2021
*, now known with p = 0.000000046 from 26 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments.
RCT 50 hospitalized patients in Israel, 33 treated with curcumin, vitamin C, artemisinin, and frankincense oral spray, showing improved recovery with treatment.
Viral load measured by PCR may not accurately reflect infectious virus measured by viral culture. Porter show that viral load early in infection was correlated with infectious virus, but viral load late in infection could be high even with low or undetectable infectious virus. Assessing viral load later in infection may underestimate reductions in infectious virus with treatment.
Targeted administration to the respiratory tract provides treatment directly to the typical source of initial SARS-CoV-2 infection and replication, and allows for rapid onset of action, higher local drug concentration, and reduced systemic side effects (early treatment may be more beneficial).
This is the 13th of 20 COVID-19 RCTs for curcumin, which collectively show efficacy with p=0.0000093.
This is the 18th of 26 COVID-19 controlled studies for curcumin, which collectively show efficacy with p=0.000000046 (1 in 22 million).
Study covers vitamin C and curcumin.
relative NEWS2 score, 76.7% better, RR 0.23, p = 0.04, treatment mean 0.52 (±0.67) n=33, control mean 2.23 (±3.2) n=17, day 15.
risk of oxygen therapy, 92.2% lower, RR 0.08, p = 0.01, treatment 0 of 33 (0.0%), control 4 of 17 (23.5%), NNT 4.2, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 15.
oxygen time, 69.7% lower, relative time 0.30, p = 0.17, treatment mean 2.3 (±1.4) n=33, control mean 7.6 (±4.6) n=17.
hospitalization time, 13.3% lower, relative time 0.87, p = 0.92, treatment mean 7.8 (±7.3) n=33, control mean 9.0 (±8.0) n=17.
risk of no viral clearance, 9.8% lower, RR 0.90, p = 0.77, treatment 14 of 33 (42.4%), control 8 of 17 (47.1%), NNT 22, day 15.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hellou et al., 19 May 2022, Double Blind Randomized Controlled Trial, placebo-controlled, Israel, peer-reviewed, 6 authors, study period 8 May, 2020 - 21 December, 2020, this trial uses multiple treatments in the treatment arm (combined with vitamin C, artemisinin, and frankincense) - results of individual treatments may vary, trial NCT04382040 (history).
This PaperCurcuminAll
Effect of ArtemiC in patients with COVID‐19: A Phase II prospective study
Elias Hellou, Jameel Mohsin, Ameer Elemy, Fahed Hakim, Mona Mustafa‐hellou, Shadi Hamoud
Journal of Cellular and Molecular Medicine, doi:10.1111/jcmm.17337
The coronavirus disease 2019 (COVID-19) pandemic, which initially emerged in Wuhan-South-eastern China in 2019, is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is associated with significant morbidity and mortality among vulnerable patients. 1 This grim situation is mainly attributed to the poor understanding of the pathogenesis of SARS-CoV-2-induced injury to vital organs, particularly in aged patients with diabetes, obesity, hypertension, heart failure and respiratory diseases. 2, 3 Critically ill cases are characterized by acute respiratory distress syndrome (ARDS) and septic shock, as well as multiple organ dysfunction or failure. [2] [3] [4] Human angiotensin-converting enzyme 2 (ACE2) receptor serves as the binding domain of SARS-CoV-2 in human host cells, exploiting its high affinity to this enzyme to inflict remarkable damage to key target organs. [5] [6] [7]
AUTH O R CO NTR I B UTI O N S Elias Hellou involved in investigation, writing-original draft (lead), review and editing (lead). Jameel Mohsin, Fahed Hakim and Ameer Elemy involved in investigation (supporting). Mona Mustafa-Hellou involved in investigation (supporting), writing-review and editing (supporting). Shadi Hamou involved in writing-original draft, review and editing (equal). CO N FLI C T O F I NTE R E S T The authors confirm that there are no conflicts of interest.
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{ 'DOI': '10.1111/jcmm.17337', 'ISSN': ['1582-1838', '1582-4934'], 'URL': '', 'abstract': '<jats:title>Abstract</jats:title><jats:p>Despite intensive efforts, there is no effective ' 'remedy for COVID‐19. Moreover, vaccination efficacy declines over time and may be compromised ' 'against new SARS‐CoV‐2\xa0lineages. Therefore, there remains an unmet need for simple, ' 'accessible, low‐cost and effective pharmacological anti‐SARS‐CoV‐2 agents. ArtemiC is a ' 'medical product comprising artemisinin, curcumin, frankincense and vitamin C, all of which ' 'possess anti‐inflammatory and anti‐oxidant properties. The present Phase II ' 'placebo‐controlled, double‐blinded, multi‐centred, prospective study evaluated the efficacy ' 'and safety of ArtemiC in patients with COVID‐19. The study included 50 hospitalized ' 'symptomatic COVID‐19 patients randomized (2:1) to receive ArtemiC or placebo oral spray, ' 'twice daily on Days 1 and 2, beside standard care. A physical examination was performed, and ' 'vital signs and blood tests were monitored daily until hospital discharge (or Day 15). A PCR ' 'assessment of SARS‐CoV‐2 carriage was performed at screening and on last visit. ArtemiC ' 'improved NEWS2 in 91% of patients and shortened durations of abnormal ' 'SpO<jats:sub>2</jats:sub> levels, oxygen supplementation and fever. No treatment‐related ' 'adverse events were reported. These findings suggest that ArtemiC curbed deterioration, ' 'possibly by limiting cytokine storm of COVID‐19, thus bearing great promise for COVID‐19 ' 'patients, particularly those with comorbidities.</jats:p>', 'alternative-id': ['10.1111/jcmm.17337'], 'assertion': [ { 'group': {'label': 'Publication History', 'name': 'publication_history'}, 'label': 'Received', 'name': 'received', 'order': 0, 'value': '2021-09-12'}, { 'group': {'label': 'Publication History', 'name': 'publication_history'}, 'label': 'Accepted', 'name': 'accepted', 'order': 1, 'value': '2022-04-05'}, { 'group': {'label': 'Publication History', 'name': 'publication_history'}, 'label': 'Published', 'name': 'published', 'order': 2, 'value': '2022-05-19'}], 'author': [ { 'ORCID': '', 'affiliation': [ {'name': 'Department of Cardiology E.M.M.S Hospital Nazareth Israel'}, {'name': 'Department of Cardiology Hillel Yaffe Hospital Hadera Israel'}, { 'name': 'Rappaport Faculty of Medicine Technion‐Israel Institute of ' 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Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop