Effect of ArtemiC in patients with COVID‐19: A Phase II prospective study
Elias Hellou, Jameel Mohsin, Ameer Elemy, Fahed Hakim, Mona Mustafa‐hellou, Shadi Hamoud
Journal of Cellular and Molecular Medicine, doi:10.1111/jcmm.17337
The coronavirus disease 2019 (COVID-19) pandemic, which initially emerged in Wuhan-South-eastern China in 2019, is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is associated with significant morbidity and mortality among vulnerable patients. 1 This grim situation is mainly attributed to the poor understanding of the pathogenesis of SARS-CoV-2-induced injury to vital organs, particularly in aged patients with diabetes, obesity, hypertension, heart failure and respiratory diseases. 2, 3 Critically ill cases are characterized by acute respiratory distress syndrome (ARDS) and septic shock, as well as multiple organ dysfunction or failure. [2] [3] [4] Human angiotensin-converting enzyme 2 (ACE2) receptor serves as the binding domain of SARS-CoV-2 in human host cells, exploiting its high affinity to this enzyme to inflict remarkable damage to key target organs. [5] [6] [7]
AUTH O R CO NTR I B UTI O N S Elias Hellou involved in investigation, writing-original draft (lead), review and editing (lead). Jameel Mohsin, Fahed Hakim and Ameer Elemy involved in investigation (supporting). Mona Mustafa-Hellou involved in investigation (supporting), writing-review and editing (supporting). Shadi Hamou involved in writing-original draft, review and editing (equal).
CO N FLI C T O F I NTE R E S T The authors confirm that there are no conflicts of interest.
References
Armaly, Kinaneh, Skorecki, Renal manifestations of Covid-19: physiology and pathophysiology, J Clin Med,
doi:10.3390/jcm10061216
Campbell, Cole, Bunditrutavorn, Vella, Ascorbic acid is a potent inhibitor of various forms of T cell apoptosis, Cell Immunol,
doi:10.1006/cimm.1999.1485
Chernyak, Popova, Prikhodko, Grebenchikov, Zinovkina et al., COVID-19 and oxidative stress
Crawford, Dingens, Eguia, Dynamics of neutralizing antibody titers in the months after SARS-CoV-2 infection, J Infect Dis,
doi:10.1093/infdis/jiaa618
Dagcioglu, Keskin, Guner, Thiol levels in mild or moderate Covid-19 patients: a comparison of variant and classic Covid-19 cases, Int J Clin Pract,
doi:10.1111/ijcp.14753
Derouiche, Oxidative stress associated with SARS-Cov-2 (COVID-19) increases the severity of the lung disease -a systematic review, J Infect Dis Epidemiol,
doi:10.23937/2474-3658/1510121
Fo R M Ati O N ; Hellou, Mohsin, Elemy, Hakim, Mustafa-Hellou et al., Additional supporting information may be found in the online version of the article at the publisher's website, J Cell Mol Med
Fowler Aa 3rd, Truwit, Hite, Effect of Vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial, JAMA,
doi:10.1001/jama.2019.11825
Gadoth, Halbrook, Blais, Cross-sectional assessment of COVID-19 vaccine acceptance among health care workers in Los Angeles, Ann Intern Med,
doi:10.7326/M20-7580
Garibaldi, Wang, Robinson, Comparison of time to clinical improvement with vs without remdesivir treatment in hospitalized patients with COVID-19, JAMA Netw Open,
doi:10.1001/jamanetworkopen.2021.3071
Group, Horby, Mafham, Effect of hydroxychloroquine in hospitalized patients with Covid-19, N Engl J Med,
doi:10.1056/NEJMoa2022926
Huang, Wang, Tan, Liu, Ni, High-dose vitamin C intravenous infusion in the treatment of patients with COVID-19: a protocol for systematic review and meta-analysis, Medicine,
doi:10.1097/MD.0000000000025876
Huang, Wang, Yang, A review of severe acute respiratory syndrome coronavirus 2 infection in the reproductive system, J Chin Med Assoc,
doi:10.1097/JCMA.0000000000000388
Iwai, Horiuchi, Devil and angel in the renin-angiotensin system: ACE-angiotensin II-AT1 receptor axis vs. ACE2-angiotensin-(1-7)-Mas receptor axis, Hypertens Res,
doi:10.1038/hr.2009.74
Li, Moore, Vasilieva, Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus, Nature,
doi:10.1038/nature02145
Liu, Vanblargan, Bloyet, Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization, Cell Host Microbe,
doi:10.1016/j.chom.2021.01.014
Mathew, Giles, Baxter, Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications, Science,
doi:10.1126/science.abc8511
Moghadamtousi, Kadir, Hassandarvish, Tajik, Abubakar et al., A review on antibacterial, antiviral, and antifungal activity of curcumin, Biomed Res Int,
doi:10.1155/2014/186864
Myrstad, Ihle-Hansen, Tveita, National Early Warning Score 2 (NEWS2) on admission predicts severe disease and inhospital mortality from Covid-19 -a prospective cohort study, Scand J Trauma Resusc Emerg Med,
doi:10.1186/s13049-020-00764-3
Ohl, Miller, Lund, Association of remdesivir treatment with survival and length of hospital stay among US veterans hospitalized with COVID-19, JAMA Netw Open,
doi:10.1001/jamanetworkopen.2021.14741
Sivaloganathan, Ladikou, Chevassut, COVID-19 mortality in patients on anticoagulants and antiplatelet agents, Br J Haematol,
doi:10.1111/bjh.16968
Tang, Liu, Zhang, Xu, Wen, Cytokine storm in COVID-19: the current evidence and treatment strategies, Front Immunol,
doi:10.3389/fimmu.2020.01708
Tsuda, Renin-Angiotensin system and sympathetic neurotransmitter release in the central nervous system of hypertension, Int J Hypertens,
doi:10.1155/2012/474870
Tu, Artemisinin-A gift from traditional Chinese medicine to the world (Nobel Lecture), Angew Chem Int Ed Engl,
doi:10.1002/anie.201601967
Wan, Shang, Graham, Baric, Li, Receptor recognition by the novel coronavirus from wuhan: an analysis based on decade-long structural studies of SARS coronavirus, J Virol,
doi:10.1128/JVI.00127-20
Wang, Teo, Teo, Chai, Virtual reality as a bridge in palliative care during COVID-19, J Palliat Med,
doi:10.1089/jpm.2020.0212
Weisblum, Schmidt, Zhang, Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants, Elife,
doi:10.7554/eLife.61312
Yang, Yu, Xu, Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a singlecentered, retrospective, observational study, Lancet Respir Med,
doi:10.1016/S2213-2600(20)30079-5
Yedjou, Njiki, Enow, Pharmacological effects of selected medicinal plants and vitamins against COVID-19, J Food Nutr,
doi:10.17303/jfn.2021.7.202
Yedjou, Njiki, Enow, Pharmacological effects of selected medicinal plants and vitamins against COVID-19, Jacobs J Food Nutr,
doi:10.17303/jfn.2021.7.202
Zhang, Dong, Cao, Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China, Allergy,
doi:10.1111/all.14238
Zhang, Zhao, Zhang, The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): the perspectives of clinical immunologists from China, Clin Immunol,
doi:10.1016/j.clim.2020.108393
Zhao, Zhao, Wang, Zhou, Ma et al., Single-cell RNA expression profiling of ACE2, the receptor of SARS-CoV-2, Am J Respir Crit Care Med,
doi:10.1164/rccm.202001-0179LE