Oral Curcumin With Piperine as Adjuvant Therapy for the Treatment of COVID-19: A Randomized Clinical Trial

{ 'indexed': {'date-parts': [[2024, 4, 8]], 'date-time': '2024-04-08T09:14:36Z', 'timestamp': 1712567676758}, 'reference-count': 36, 'publisher': 'Frontiers Media SA', 'license': [ { 'start': { 'date-parts': [[2021, 5, 28]], 'date-time': '2021-05-28T00:00:00Z', 'timestamp': 1622160000000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': ['frontiersin.org'], 'crossmark-restriction': True}, 'abstract': '<jats:p><jats:bold>Background:</jats:bold> Coronavirus disease-2019 (COVID-19) has a wide ' 'range of pathophysiological effects. Curcumin, an active constituent of Curcuma longa ' '(turmeric), has several properties, including anti-inflammatory, antioxidant, antiviral, ' 'anti-thrombotic, and anti-proliferative effects, which make it a promising candidate for the ' 'symptomatic treatment of COVID-19.</jats:p><jats:p><jats:bold>Objective:</jats:bold> We aimed ' 'to determine the effects of curcumin administered with piperine (to optimize absorption) on ' 'symptoms in patients with COVID-19 in a double-blind, randomized, controlled trial at a ' '30-bed dedicated COVID Health Center (DCHC) in Maharashtra, ' 'India.</jats:p><jats:p><jats:bold>Methods:</jats:bold> In addition to conventional COVID-19 ' 'treatment, patients in the control group received a dose of probiotics twice a day, and ' 'patients in the study group received curcumin (525\xa0mg) with piperine (2.5\xa0mg) in tablet ' 'form twice a day. The effects of curcumin/piperine treatment on primary and secondary ' 'outcomes were assessed for the duration of ' 'hospitalization.</jats:p><jats:p><jats:bold>Results:</jats:bold> Patients with mild, ' 'moderate, and severe symptoms who received curcumin/piperine treatment showed early ' 'symptomatic recovery (fever, cough, sore throat, and breathlessness), less deterioration, ' 'fewer red flag signs, better ability to maintain oxygen saturation above 94% on room air, and ' 'better clinical outcomes compared to patients of the control group. Furthermore, ' 'curcumin/piperine treatment appeared to reduce the duration of hospitalization in patients ' 'with moderate to severe symptoms, and fewer deaths were observed in the curcumin/piperine ' 'treatment group.</jats:p><jats:p><jats:bold>Conclusions:</jats:bold> Administration of oral ' 'curcumin with piperine as an adjuvant symptomatic therapy in COVID-19 treatment could ' 'substantially reduce morbidity and mortality, and ease the logistical and supply-related ' 'burdens on the healthcare system. Curcumin could be a safe and natural therapeutic option to ' 'prevent Post-Covid thromboembolic events.</jats:p><jats:p><jats:bold>Clinicaltrials.gov ' 'identifier:</jats:bold><jats:ext-link>CTRI/2020/05/025482</jats:ext-link></jats:p>', 'DOI': '10.3389/fphar.2021.669362', 'type': 'journal-article', 'created': {'date-parts': [[2021, 5, 28]], 'date-time': '2021-05-28T07:58:34Z', 'timestamp': 1622188714000}, 'update-policy': 'http://dx.doi.org/10.3389/crossmark-policy', 'source': 'Crossref', 'is-referenced-by-count': 105, 'title': 'Oral Curcumin With Piperine as Adjuvant Therapy for the Treatment of COVID-19: A Randomized ' 'Clinical Trial', 'prefix': '10.3389', 'volume': '12', 'author': [ {'given': 'Kirti S', 'family': 'Pawar', 'sequence': 'first', 'affiliation': []}, {'given': 'Rahul N', 'family': 'Mastud', 'sequence': 'additional', 'affiliation': []}, {'given': 'Satheesh K', 'family': 'Pawar', 'sequence': 'additional', 'affiliation': []}, {'given': 'Samragni S', 'family': 'Pawar', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rahul R', 'family': 'Bhoite', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ramesh R', 'family': 'Bhoite', 'sequence': 'additional', 'affiliation': []}, {'given': 'Meenal V', 'family': 'Kulkarni', 'sequence': 'additional', 'affiliation': []}, {'given': 'Aditi R', 'family': 'Deshpande', 'sequence': 'additional', 'affiliation': []}], 'member': '1965', 'published-online': {'date-parts': [[2021, 5, 28]]}, 'reference': [ { 'key': 'B1', 'doi-asserted-by': 'publisher', 'first-page': '40', 'DOI': '10.1016/j.biocel.2008.06.010', 'article-title': 'Potential Therapeutic Effects of Curcumin, the Anti-inflammatory Agent, ' 'against Neurodegenerative, Cardiovascular, Pulmonary, Metabolic, ' 'Autoimmune and Neoplastic Diseases', 'volume': '41', 'author': 'Aggarwal', 'year': '2009', 'journal-title': 'Int. 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