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All Studies   Meta Analysis    Recent:   

Curcumin as adjuvant Therapy in Mild - Moderate Covid 19

Kartika et al., ICE on IMERI, 2021
Jan 2022  
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0 0.5 1 1.5 2+ Hospitalization time 41% Improvement Relative Risk Curcumin for COVID-19  Kartika et al.  LATE TREATMENT Is late treatment with curcumin beneficial for COVID-19? Retrospective 246 patients in Indonesia (January - June 2021) Shorter hospitalization with curcumin (p=0.048) c19early.org Kartika et al., ICE on IMERI, 2021, Jan 2022 Favors curcumin Favors control
Curcumin for COVID-19
14th treatment shown to reduce risk in February 2021
 
*, now known with p = 0.000000015 from 26 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
Retrospective 246 hospitalized patients in Indonesia, 136 treated with curcumin, showing shorter hospitalization time with treatment. All patients received vitamin C, D, and zinc.
This is the 12th of 26 COVID-19 controlled studies for curcumin, which collectively show efficacy with p=0.000000015 (1 in 66 million).
20 studies are RCTs, which show efficacy with p=0.0000033.
hospitalization time, 41.0% lower, relative time 0.59, p = 0.048, treatment 139, control 107.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kartika et al., 28 Jan 2022, retrospective, Indonesia, preprint, 6 authors, study period January 2021 - June 2021.
This PaperCurcuminAll
CURCUMIN AS ADJUVANT THERAPY IN MILD-MODERATE COVID 19
Ronald Winardi Kartika, Marcel Tendean, Bernard Jonathan Christian, Katarina Dewi Sartika, Eka Widrian Suradji, Irsan Hasan, Ronald Winardi Kartika
Background: Coronavirus (Covid-19) has spread rapidly to more than 200 countries, including Indonesia. Adjuvant therapy of Vitamin C, D, Zinc has become beneficial for Covid-19 treatment to improve the immune system, while Curcumin is still not standard therapy. Curcumin can stimulate specific immune cells and can reduce oxidative stress. There is currently no scientific evidence showing that the addition of Curcumin can protect COVID-19, especially as an anti-inflammation and anticoagulant effect. Methods: This cross-sectional study was conducted at Ukrida Hospital from January -June 2021. The inclusion criteria are Mild-Moderate Covid-19 use on Curcumin and Supplement therapy ( Vitamin C, Vitamin D, and zinc). Data analyses with SPSS v.20 use Anova test and Kruskall Walis test. This study had been approved by The Institutional Board of the Faculty of Medicine Universitas Krida Wacana, Indonesia (No. 1053/SLKE-IM/UKKW/FKIK/KE/II/2021). Research Objectives: To see the effect of Curcumin as an additional therapy from Covid-19 by clinical and laboratory inflammation indicators of the usefulness of Curcumin are such as ratio neutrophil/lymphocyte, ratio platelet/lymphocyte, erythrocyte sedimentation rate (ESR), C-Reactive Protein ( CRP), and D Dimer. Results: There were 246 cases, with 62.6% male and 56.5% female taking Curcumin. Curcumin has a good effect in reducing inflammation and coagulation in mild-moderate Covid-19. Patient who got Curcumin or without Curcumin as additional supplement therapy shows patient that got Curcumin has decreased inflammatory markers N/L ratio (p = 0.041), P/L ratio (p = 0.040), ESR (p = 0.013 ), and CRP ( p= 0.045). Curcumin also has an anticoagulant effect that shows a decrease of D-Dimer ( p= 0.020). Conclusion: Curcumin is beneficial in mild-moderate Covid-19 as an anti-inflammatory and anticoagulant.
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Late treatment
is less effective
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