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0 0.5 1 1.5 2+ Progression 94% Improvement Relative Risk Recovery 38% Hospitalization time 45% Curcumin  Saber-Moghaddam et al.  EARLY TREATMENT Is early treatment with curcumin beneficial for COVID-19? Prospective study of 41 patients in Iran Lower progression (p=0.0013) and improved recovery (p=0.043) Saber-Moghaddam et al., Phytotherapy R.., Jan 2021 Favors curcumin Favors control

Oral nano-curcumin formulation efficacy in management of mild to moderate hospitalized coronavirus disease-19 patients: An open label nonrandomized clinical trial

Saber-Moghaddam et al., Phytotherapy Research, doi:10.1002/ptr.7004
Jan 2021  
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Small prospective nonrandomized trial with 41 patients, 21 treated with curcumin, showing lower disease progression and faster recovery with treatment. IRCT20200408046990N1.
This is the 2nd of 26 COVID-19 controlled studies for curcumin, which collectively show efficacy with p=0.000000046 (1 in 22 million). 20 studies are RCTs, which show efficacy with p=0.0000093.
risk of progression, 94.3% lower, RR 0.06, p = 0.001, treatment 0 of 21 (0.0%), control 8 of 20 (40.0%), NNT 2.5, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of no recovery, 38.4% lower, RR 0.62, p = 0.04, treatment 11 of 21 (52.4%), control 17 of 20 (85.0%), NNT 3.1.
hospitalization time, 44.8% lower, relative time 0.55, p < 0.001, treatment 21, control 20.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Saber-Moghaddam et al., 3 Jan 2021, prospective, Iran, peer-reviewed, 9 authors.
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Oral nano‐curcumin formulation efficacy in management of mild to moderate hospitalized coronavirus disease ‐19 patients: An open label nonrandomized clinical trial
Niloofar Saber‐moghaddam, Soofia Salari, Sepideh Hejazi, Mahnaz Amini, Zhila Taherzadeh, Saeed Eslami, Seyed Mahdi Rezayat, Mahmoud Reza Jaafari, Sepideh Elyasi
Phytotherapy Research, doi:10.1002/ptr.7004
Curcumin is proposed as a potential treatment option for coronavirus disease-19 by inhibiting the virus entrance, encapsulation and replication, and modulating various cellular signaling pathways. In this open-label nonrandomized clinical trial, efficacy of nano-curcumin oral formulation has been evaluated in hospitalized patients with mild-moderate COVID-19. Forty-one patients who fulfilled the inclusion criteria were allocated to nano-curcumin (n = 21) group (Sinacurcumin soft gel, contains 40 mg curcuminoids as nanomicelles, two capsules twice a day) or control (n = 20) group, for 2 weeks. Patients' symptoms and laboratory data were assessed at baseline and during follow-up period. Most of symptoms including fever and chills, tachypnea, myalgia, and cough resolved significantly faster in curcumin group. Moreover, SaO 2 was significantly higher in treatment group after 2, 4, 7, and 14 days of follow-up and lymphocyte count after 7 and 14 days. Duration of supplemental O 2 use and hospitalization was also meaningfully shorter in treatment group. It is also noteworthy to mention that no patient in treatment group experienced deterioration of infection during follow-up period, but it occurred in 40% of control group. Oral curcumin nano-formulation can significantly improve recovery time in hospitalized COVID-19 patients. Further randomized placebo controlled trials with larger sample size are recommended.
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