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0 0.5 1 1.5 2+ Viral clearance, day 10 53% Improvement Relative Risk Viral clearance, day 14 75% Viral clearance, day 21 67% Curcumin  Hartono et al.  LATE TREATMENT  RCT Is late treatment with curcumin + virgin coconut oil beneficial for COVID-19? RCT 60 patients in Indonesia (May - September 2020) Improved viral clearance with curcumin + virgin coconut oil (p=0.0000019) Hartono et al., Pharmacognosy J., February 2022 Favors curcumin Favors control

The Effect of Curcumin and Virgin Coconut Oil Towards Cytokines Levels in COVID-19 Patients at Universitas Sebelas Maret Hospital, Surakarta, Indonesia

Hartono et al., Pharmacognosy Journal, doi:10.5530/pj.2022.14.27
Feb 2022  
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Curcumin for COVID-19
14th treatment shown to reduce risk in February 2021
*, now known with p = 0.000000046 from 26 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments.
RCT with 30 patients treated with curcumin and virgin coconut oil (VCO), and 30 SOC patients in Indonesia, showing faster viral clearance with treatment. Treatment also reduced IL-1β, IL-2, IL-6, IL-18, and IFN-β levels. VCO improves the bioavailability of curcumin. There were large unadjusted differences in baseline severity and age, for example 20% vs. 47% of patients >50. VCO 30ml and curcumin 1g tid for 21 days. 066/UN27.06.6.1/KEPK/EC/2020.
This is the 9th of 20 COVID-19 RCTs for curcumin, which collectively show efficacy with p=0.0000093.
This is the 13th of 26 COVID-19 controlled studies for curcumin, which collectively show efficacy with p=0.000000046 (1 in 22 million).
This study is excluded in the after exclusion results of meta analysis: randomization resulted in significant baseline differences that were not adjusted for.
risk of no viral clearance, 53.3% lower, RR 0.47, p < 0.001, treatment 14 of 30 (46.7%), control 30 of 30 (100.0%), NNT 1.9, day 10.
risk of no viral clearance, 75.0% lower, RR 0.25, p = 0.002, treatment 4 of 30 (13.3%), control 16 of 30 (53.3%), NNT 2.5, day 14.
risk of no viral clearance, 66.7% lower, RR 0.33, p = 1.00, treatment 0 of 30 (0.0%), control 1 of 30 (3.3%), NNT 30, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 21.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hartono et al., 22 Feb 2022, Randomized Controlled Trial, Indonesia, peer-reviewed, 13 authors, study period May 2020 - September 2020, this trial uses multiple treatments in the treatment arm (combined with virgin coconut oil) - results of individual treatments may vary.
This PaperCurcuminAll
The Effect of Curcumin and Virgin Coconut Oil Towards Cytokines Levels in COVID-19 Patients at Universitas Sebelas Maret Hospital, Surakarta, Indonesia
Hartono Hartono, B Suryawati, Y Sari, A Avicena, Maryani Maryani, C Sukmagautama, H Apriningsih, L Shofiyah, Rgh Novika, N J Wahidah, N Y Rahmawati, Anm Ansori, L Sumarno
Pharmacognosy Journal, doi:10.5530/pj.2022.14.27
Coronavirus Disease 2019 (COVID-19) is a respiratory disease reported to have emerged in late December 2019 in Wuhan, China. It causes by a novel coronavirus known as Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). COVID-19 has grown rapidly and was declared a pandemic by WHO. 1 In patients with severe MERS, serum cytokine and chemokine levels are significantly higher than those in patients with mild to moderate MERS.
DISCLOSURE STATEMENT The authors have no conflicts of interest to declare. AUTHOR CONTRIBUTION H ABOUT AUTHORS
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Hartono, The Effect of Curcumin and Virgin Coconut Oil Towards Cytokines Levels in COVID-19 Patients at Universitas Sebelas Maret Hospital
Hartono, involved in Indonesia-National Adolescent Mental Health Survey by Universitas Gadjah Mada -John Hopkins University and in Clinical trial research on the effect of ethanol extract of gendarussa capsules as male nonhormonal contraceptives
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Late treatment
is less effective
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