A prospective, multi center, single blind, randomized controlled study evaluating “AyurCoro3” as an adjuvant in the treatment of mild to moderate COVID

Sankhe et al., Journal of Ayurveda and Integrated Medical Sciences, doi:10.21760/jaims.6.4.6, Aug 2021

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Curcumin for COVID-19

16th treatment shown to reduce risk in February 2021, now with p = 0.0000000061 from 28 studies.

Lower risk for mortality, ventilation, hospitalization, progression, recovery, and viral clearance.

No treatment is 100% effective. Protocols combine treatments.

6,200+ studies for 180+ treatments. c19early.org

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RCT 174 patients in India, 87 treated with AyurCoro-3 (turmeric, gomutra, potassium alum, khadisakhar, bos indicus milk, ghee), showing faster recovery with treatment. EC/NEW/INST/2019/245.

This is the 5th of 21 COVID-19 RCTs for curcumin, which collectively show efficacy with p=0.0000022.

This is the 8th of 28 COVID-19 controlled studies for curcumin, which collectively show efficacy with p=0.0000000061 (1 in 164 million).

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risk of death, 88.9% lower, RR 0.11, p = 0.12, treatment 0 of 87 (0.0%), control 4 of 87 (4.6%), NNT 22, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).

risk of mechanical ventilation, 75.0% lower, RR 0.25, p = 0.37, treatment 1 of 87 (1.1%), control 4 of 87 (4.6%), NNT 29.

risk of no 2-point improvement, 46.5% lower, RR 0.54, p = 0.002, treatment 29 of 87 (33.3%), control 60 of 87 (69.0%), NNT 2.8, inverted to make RR<1 favor treatment, odds ratio converted to relative risk, day 7 mid-recovery.

hospitalization time, 10.0% lower, relative time 0.90, p = 0.40, treatment 87, control 87.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Sankhe et al., 10 Aug 2021, Randomized Controlled Trial, India, peer-reviewed, 8 authors, study period October 2020 - March 2021, this trial uses multiple treatments in the treatment arm (combined with gomutra, potassium alum, khadisakhar, bos indicus milk, ghee) - results of individual treatments may vary.

This Paper Curcumin All

A prospective, multi center, single blind, randomized controlled study evaluating "AyurCoro3" as an adjuvant in the treatment of mild to moderate COVID-19 patients

Dr Ajay Prabhakar Sankhe, Nanasaheb Somnath Memane, Vijaykumar P Gawali, Sonal Nanasaheb Memane, Ganesh Ramakrishnan, Mayur Nimba Bagul, Rashmi Tiwari, Vikram Bansal, Ayurveda Head, Dept, Clinical Research Head, Consultant Ayurveda, Somnath Nanasaheb, Vijaykumar P Memane, Gawali, Nanasaheb Sonal, Ganesh Memane, Mayur Nimba Ramakrishnan, Rashmi Bagul, Vikram Tiwari, Bansal

doi:10.21760/jaims.6.4.6

INTRODUCTION The Coronavirus disease (COVID-19) has affected the world worst with over 158 million patients infected

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