Efficacy of Nanocurcumin as an Add-On Treatment for Patients Hospitalized with COVID-19: A Double-Blind, Randomized Clinical Trial

{ 'indexed': {'date-parts': [[2023, 7, 29]], 'date-time': '2023-07-29T04:24:28Z', 'timestamp': 1690604668584}, 'reference-count': 41, 'publisher': 'Hindawi Limited', 'license': [ { 'start': { 'date-parts': [[2023, 7, 28]], 'date-time': '2023-07-28T00:00:00Z', 'timestamp': 1690502400000}, 'content-version': 'unspecified', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'funder': [ { 'DOI': '10.13039/501100004320', 'name': 'Shiraz University of Medical Sciences', 'doi-asserted-by': 'publisher', 'award': ['23550']}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2023, 7, 28]]}, 'abstract': '<jats:p>Background. Curcumin is a polyphenol derivative of the Curcuma longa rhizome, with ' 'potential antioxidant, anticancer, antidepressant, antiviral, and anti-inflammatory effects. ' 'This compound can be prepared as biodegradable polymer nanoparticles, called nanocurcumin, to ' 'improve its solubility, stability, half-life, and bioavailability. Aim. We explored ' 'nanocurcumin’s effect on the clinical manifestations of patients hospitalized with ' 'mild-to-moderate COVID-19. Methods. This double-blind, randomized clinical trial involved 76 ' 'COVID-19 patients admitted to Ali-Asghar Hospital from December 2021 to March 2022. All ' 'patients received standard coronavirus treatment as per national guidelines. In addition, ' 'four times a day for two weeks, the curcumin group received 40\u2009mg of nanocurcumin, while ' 'the control group received a placebo. Clinical manifestations were examined and recorded by ' 'the associate doctors working in the department. Statistical analysis was done using SPSS v. ' '21. Results. Thirty-nine people from the control group and 29 from the curcumin group ' 'completed the study. At baseline, the groups were comparable in age, gender, body mass index, ' 'hospitalization duration, and background diseases. The mean age of patients in the control ' 'and treatment groups was 53.9\u2009±\u200911.9 and 54.6\u2009±\u200913.4, respectively. ' 'Compared with the placebo, nanocurcumin minimized coughs (<jats:inline-formula>\n' ' <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1">\n' ' <mi>P</mi>\n' ' <mo>=</mo>\n' ' <mn>0.036</mn>\n' ' </math>\n' ' </jats:inline-formula>), fatigue (<jats:inline-formula>\n' ' <math xmlns="http://www.w3.org/1998/Math/MathML" id="M2">\n' ' <mi>P</mi>\n' ' <mo>=</mo>\n' ' <mn>0.0001</mn>\n' ' </math>\n' ' </jats:inline-formula>), myalgia (<jats:inline-formula>\n' ' <math xmlns="http://www.w3.org/1998/Math/MathML" id="M3">\n' ' <mi>P</mi>\n' ' <mo>=</mo>\n' ' <mn>0.027</mn>\n' ' </math>\n' ' </jats:inline-formula>), oxygen demand (<jats:inline-formula>\n' ' <math xmlns="http://www.w3.org/1998/Math/MathML" id="M4">\n' ' <mi>P</mi>\n' ' <mo>=</mo>\n' ' <mn>0.036</mn>\n' ' </math>\n' ' </jats:inline-formula>), oxygen usage (<jats:inline-formula>\n' ' <math xmlns="http://www.w3.org/1998/Math/MathML" id="M5">\n' ' <mi>P</mi>\n' ' <mo>=</mo>\n' ' <mn>0.05</mn>\n' ' </math>\n' ' </jats:inline-formula>), and respiratory rate (<jats:inline-formula>\n' ' <math xmlns="http://www.w3.org/1998/Math/MathML" id="M6">\n' ' <mi>P</mi>\n' ' <mo>&lt;</mo>\n' ' <mn>0.0001</mn>\n' ' </math>\n' ' </jats:inline-formula>). By discharge, the curcumin group had a ' 'significantly greater increase in SPO2 than the control group (<jats:inline-formula>\n' ' <math xmlns="http://www.w3.org/1998/Math/MathML" id="M7">\n' ' <mi>P</mi>\n' ' <mo>=</mo>\n' ' <mn>0.006</mn>\n' ' </math>\n' ' </jats:inline-formula>). Conclusions. This preliminary study suggests that ' 'nanocurcumin has a potentiating anti-inflammatory effect when combined with standard COVID-19 ' 'treatment, helping the recovery from the acute inflammatory phase of the disease in ' 'hospitalized patients with mild-to-moderate disease severity. This trial is registered with ' 'Iranian Registry of Clinical Trials: IRCT20211126053183N1 (registered while recruiting on ' '13/12/2021).</jats:p>', 'DOI': '10.1155/2023/5734675', 'type': 'journal-article', 'created': {'date-parts': [[2023, 7, 29]], 'date-time': '2023-07-29T02:20:12Z', 'timestamp': 1690597212000}, 'page': '1-7', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Efficacy of Nanocurcumin as an Add-On Treatment for Patients Hospitalized with COVID-19: A ' 'Double-Blind, Randomized Clinical Trial', 'prefix': '10.1155', 'volume': '2023', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-2969-3125', 'authenticated-orcid': True, 'given': 'Sedigheh', 'family': 'Ahmadi', 'sequence': 'first', 'affiliation': [ { 'name': 'Student Research Committee, Shiraz University of Medical ' 'Sciences, Shiraz, Iran'}]}, { 'ORCID': 'http://orcid.org/0000-0002-5855-2153', 'authenticated-orcid': True, 'given': 'Zeinab', 'family': 'Mehrabi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Internal Medicine, Shiraz University of Medical ' 'Sciences, Shiraz, Iran'}]}, { 'ORCID': 'http://orcid.org/0000-0001-7157-9265', 'authenticated-orcid': True, 'given': 'Morteza', 'family': 'Zare', 'sequence': 'additional', 'affiliation': [ { 'name': 'Nutrition Research Center, School of Nutrition and Food ' 'Sciences, Shiraz University of Medical Sciences, Shiraz, Iran'}]}, { 'ORCID': 'http://orcid.org/0000-0001-9976-5887', 'authenticated-orcid': True, 'given': 'Sara', 'family': 'Ghadir', 'sequence': 'additional', 'affiliation': [ { 'name': 'Student Research Committee, Shiraz University of Medical ' 'Sciences, Shiraz, Iran'}]}, { 'ORCID': 'http://orcid.org/0000-0001-6712-6802', 'authenticated-orcid': True, 'given': 'Seyed Jalil', 'family': 'Masoumi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Nutrition Research Center, School of Nutrition and Food ' 'Sciences, Shiraz University of Medical Sciences, Shiraz, Iran'}, { 'name': 'Gastroenterohepatology Research Center, Shiraz University of ' 'Medical Sciences, Shiraz, Iran'}, { 'name': 'Center for Cohort Study of SUMS Employees’ Health, Shiraz ' 'University of Medical Sciences, Shiraz, Iran'}]}], 'member': '98', 'reference': [ { 'issue': '10223', 'key': '1', 'doi-asserted-by': 'crossref', 'first-page': '497', 'DOI': '10.1016/S0140-6736(20)30183-5', 'article-title': 'Clinical features of patients infected with 2019 novel coronavirus in ' 'Wuhan, China', 'volume': '395', 'author': 'C. 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Safarzadeh Kozani', 'year': '2022', 'journal-title': 'COVID-19 Vaccines in Iran'}], 'container-title': 'International Journal of Clinical Practice', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'http://downloads.hindawi.com/journals/ijclp/2023/5734675.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'http://downloads.hindawi.com/journals/ijclp/2023/5734675.xml', 'content-type': 'application/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'http://downloads.hindawi.com/journals/ijclp/2023/5734675.pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 7, 29]], 'date-time': '2023-07-29T02:20:40Z', 'timestamp': 1690597240000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.hindawi.com/journals/ijclp/2023/5734675/'}}, 'subtitle': [], 'editor': [{'given': 'Leandro Napier', 'family': 'de Souza', 'sequence': 'additional', 'affiliation': []}], 'short-title': [], 'issued': {'date-parts': [[2023, 7, 28]]}, 'references-count': 41, 'alternative-id': ['5734675', '5734675'], 'URL': 'http://dx.doi.org/10.1155/2023/5734675', 'relation': {}, 'ISSN': ['1742-1241', '1368-5031'], 'subject': ['General Medicine'], 'container-title-short': 'International Journal of Clinical Practice', 'published': {'date-parts': [[2023, 7, 28]]}}