Efficacy of Nanocurcumin as an Add-On Treatment for Patients Hospitalized with COVID-19: A Double-Blind, Randomized Clinical Trial
International Journal of Clinical Practice, doi:10.1155/2023/5734675
Background. Curcumin is a polyphenol derivative of the Curcuma longa rhizome, with potential antioxidant, anticancer, antidepressant, antiviral, and anti-infammatory efects. Tis compound can be prepared as biodegradable polymer nanoparticles, called nanocurcumin, to improve its solubility, stability, half-life, and bioavailability. Aim. We explored nanocurcumin's efect on the clinical manifestations of patients hospitalized with mild-to-moderate COVID-19. Methods. Tis double-blind, randomized clinical trial involved 76 COVID-19 patients admitted to Ali-Asghar Hospital from December 2021 to March 2022. All patients received standard coronavirus treatment as per national guidelines. In addition, four times a day for two weeks, the curcumin group received 40 mg of nanocurcumin, while the control group received a placebo. Clinical manifestations were examined and recorded by the associate doctors working in the department. Statistical analysis was done using SPSS v. 21. Results. Tirty-nine people from the control group and 29 from the curcumin group completed the study. At baseline, the groups were comparable in age, gender, body mass index, hospitalization duration, and background diseases. Te mean age of patients in the control and treatment groups was 53.9 ± 11.9 and 54.6 ± 13.4, respectively. Compared with the placebo, nanocurcumin minimized coughs (P � 0.036), fatigue (P � 0.0001), myalgia (P � 0.027), oxygen demand (P � 0.036), oxygen usage (P � 0.05), and respiratory rate (P < 0.0001). By discharge, the curcumin group had a signifcantly greater increase in SPO 2 than the control group (P � 0.006). Conclusions. Tis preliminary study suggests that nanocurcumin has a potentiating anti-infammatory efect when combined with standard COVID-19 treatment, helping the recovery from the acute infammatory phase of the disease in hospitalized patients with mild-to-moderate disease severity. Tis trial is registered with Iranian Registry of Clinical Trials: IRCT20211126053183N1 (registered while recruiting on 13/12/2021).
Ethical Approval Tis study was conducted in line with the ethical principles of Shiraz University of Medical Sciences (Ethics Committee approval code: IR.SUMS.SCHEANUT.REC.1400.031) and the Helsinki Declaration of 1964 and its later amendments.
Consent Informed consent was obtained from all subjects.
Disclosure Te present article was extracted from the dissertation written by Sedigheh Ahmadi.
Conflicts of Interest Te authors declare that they have no conficts of interest.
Authors' Contributions SA was responsible for study design, implementation, data interpretation, original draft preparation, and manuscript revision. ZM was responsible for study design, data collection, and manuscript revision. MZ was responsible for study design, data analysis, and manuscript revision. SG was responsible for study implementation, data interpretation, and original draft preparation. SJM was responsible for study concept, design, funding acquisition, implementation, supervision, and manuscript revision. All authors have read and approved the fnal version of the manuscript.
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