Effect of natural products use prior to infection with COVID-19 on disease severity and hospitalization: A self-reported cross-sectional survey study
et al., F1000Research, doi:10.12688/f1000research.121933.1
, Effect of natural products use prior to infection with COVID-19 on disease severity and hospitalization: A.., F1000Research, doi:10.12688/f1000research.121933.1
Survey 2,148 COVID-19 recovered patients in Jordan, showing lower hospitalization with turmeric prophylaxis, not reaching statistical significance.Although the 31% lower hospitalization is not statistically significant, it is consistent with the significant 25% lower hospitalization [15‑33%] from meta analysis of the 10 hospitalization results to date.This is the 20th of 24 COVID-19 controlled studies for curcumin, which collectively show efficacy with p=0.000000053 (1 in 19 million). 19 studies are RCTs, which show efficacy with p=0.0000049.
|
risk of hospitalization, 30.8% lower, RR 0.69, p = 0.08, treatment 29 of 329 (8.8%), control 179 of 1,819 (9.8%), adjusted per study, odds ratio converted to relative risk, multivariable.
|
|
risk of severe case, 12.6% lower, RR 0.87, p = 0.47, treatment 40 of 329 (12.2%), control 211 of 1,819 (11.6%), adjusted per study, odds ratio converted to relative risk, multivariable.
|
| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Nimer et al., 10 Jun 2022, retrospective, Jordan, peer-reviewed, survey, mean age 40.2, 4 authors, study period March 2021 - July 2021.
Contact:
rmnimer@just.edu.jo.
Effect of natural products use prior to infection with COVID-19 on disease severity and hospitalization: A self-reported cross-sectional survey study
F1000Research, doi:10.12688/f1000research.121933.1
Background: Managing coronavirus disease 2019 (COVID-19) using available resources is essential to reduce the health burden of disease. The severity of COVID-19 is affected by nutritional status. In this study the effect of natural product use prior to infection with COVID-19 on disease severity and hospitalization was explored. Methods: This was a cross-sectional study. Between March and July 2021, a self-administered survey was conducted in Jordan. Individuals who recovered from COVID-19 and were ≥18 years old were the study population. Study measures included the use of natural products, COVID-19 severity, and hospitalization status. A multivariate regression model was used for statistical analysis. Results: The mean age (mean ± SD) of the study sample (n=2,148) was 40.25 ± 15.58 years old. Multivariate logistic regression showed that the regular intake of carnation (OR [0.56], CI [0.37-0.85]), onion (OR [0.69], CI [0.52-0.92]), lemon (OR [0.68], CI [0.51-0.90]), and citrus fruits (OR [0.66], CI [0.50-0.89]) before infection were associated with a substantial reduction in COVID-19 severity (P<0.01). Also, the consumption of carnation (OR [0.55], CI [0.34-0.88]), lemon (OR [0.57], CI [0.42-0.78]), and citrus fruits (OR [0.61], CI [0.44-0.84]) were associated with a significant decrease in the frequency of COVID-19induced hospitalization (P<0.01). Conclusions: Regular consumption of carnation, lemon, and citrus fruits before infection was associated with better outcomes for COVID-19. Studies on other populations are required to confirm these findings.
Summary: The study explored the association between using specific natural products prior to COVID-19 infection and the severity of the disease and hospitalization status in a sample of Jordanian adults. Title: This is a retrospective study, the study design included a survey about prior COVID-19 infection and natural products consumption prior to infection.
Methods: -Recruitment method is not clear, how the investigators reached out to the potential participants is not stated. The study suggests that only people who were previously infected with COVID-19 were included in the study. This assumption should be discussed in the inclusion criteria. -Calculation of the study sample assumed that the total population is the number of COVID-19 infected people as reported by the end of July 2021. Does this report include only adults or total confirmed cases? As the survey targeted only adults, the authors should identify precisely the study population as a reference for sample size calculation.
Results: -Why is lemon considered a separate category from citrus? I suggest including all citrus fruit, including lemon as one category. -In table 1, the results were expressed in a different format, I suggest having all the results expressed as N (%). For this purpose, age can be categorized into 2-3 categories, and same for BMI. -In the multivariate logistic regression, the authors mentioned that after controlling for covariate, the findings... What are the covariates? The authors should..
References
Abedi, Ghasemi, Farkhondeh, Possible potential effects of honey and its main components against covid-19 infection, Dose-Response, doi:10.1177/1559325820982423
Aldwihi, Khan, Alamri, Patients' Behavior Regarding Dietary or Herbal Supplements before and during COVID-19 in Saudi Arabia, Int. J. Environ. Res. Public Health, doi:10.3390/ijerph18105086
Alghamdi, Mohammed, Alfahaid, Herbal medicine use by Saudi patients with chronic diseases: A cross-sectional study (experience from Southern Region of Saudi Arabia), Journal of Health Specialties, doi:10.4103/jhs.JHS_157_17
Almahasheer, Nutrition in herbal plants used in Saudi Arabia, Scientifica
Alotiby, Naif, Prevalence of using herbs and natural products as a protective measure during the COVID-19 pandemic among the Saudi population: an online crosssectional survey, Saudi Pharm. J, doi:10.1016/j.jsps.2021.04.001
Antonio, Wiedemann, Galante, Efficacy and sustainability of natural products in COVID-19 treatment development: opportunities and challenges in using agroindustrial waste from Citrus and apple, Heliyon, doi:10.1016/j.heliyon.2021.e07816
Bahramsoltani, Rahimi, An Evaluation of Traditional Persian Medicine for the Management of SARS-CoV-2, Front. Pharmacol
Barreca, Mandalari, Calderaro, Citrus flavones: An update on sources, biological functions, and health promoting properties, Plan. Theory
Bayer, Jfhwjcbceccabayer, Crop Science-Jordan
Bettuzzi, Gabba, Cataldo, Efficacy of a polyphenolic, standardized green tea extract for the treatment of COVID-19 syndrome: A proof-of-principle study, Covid, doi:10.3390/covid1010002
Bondhon, Jannat, In silico screening of Allium cepa phytochemicals for their binding abilities to SARS and SARS-CoV-2 3C-like protease and COVID-19 human receptor ACE-2, Trop. Biomed
Chaieb, Hajlaoui, Zmantar, The chemical composition and biological activity of clove essential oil, Eugenia caryophyllata (Syzigium aromaticum L. Myrtaceae): a short review, Phytother. Res
Cheng, Huynh, Yang, Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection, Nutrients, doi:10.3390/nu13082800
Cheng, Yang, Hu, Curcumin attenuates pulmonary inflammation in lipopolysaccharide induced acute lung injury in neonatal rat model by activating peroxisome proliferatoractivated receptor γ (PPARγ) pathway, Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
D'amore, Gradogna, Palombi, The Discovery of Naringenin as Endolysosomal Two-Pore Channel Inhibitor and Its Emerging Role in SARS-CoV-2 Infection, Cells, doi:10.3390/cells10051130
Dilokthornsakul, Kosiyaporn, Wuttipongwaragon, Potential effects of propolis and honey in COVID-19 prevention and treatment: A systematic review of in silico and clinical studies, J. Integr. Med
Dorsch, Ring, Anti-inflammatory substances from onions could be an option for treatment of COVID-19 -a hypothesis, Allergo Journal: interdisziplinare Zeitschrift fur Allergologie und Umweltmedizin: Organ der Deutschen Gesellschaft fur Allergie-und Immunitatsforschung
Dorsch, Ring, Anti-inflammatory substances from onions could be an option for treatment of COVID-19-a hypothesis, Allergo J. Int, doi:10.1007/s15007-020-2644-9
El-Hashim, Khajah, Orabi, Onion Bulb extract downregulates EGFR/ERK1/2/AKT signaling pathway and synergizes with steroids to inhibit allergic inflammation, Front. Pharmacol, doi:10.3389/fphar.2020.551683
Elwakil, Shaaban, Bekhit, Potential anti-COVID-19 activity of Egyptian propolis using computational modeling, Futur. Virol, doi:10.2217/fvl-2020-0329
Gasmi, Chirumbolo, Peana, The Role of Diet and Supplementation of Natural Products in COVID-19 Prevention, Biol. Trace Elem. Res
Ghorani, Marefati, Shakeri, The effects of Allium cepa extract on tracheal responsiveness, lung inflammatory cells and phospholipase A2 level in asthmatic rats. Iran, J. Allergy Asthma Immunol
Guler, Tatar, Yildiz, Investigation of potential inhibitor properties of ethanolic propolis extracts against ACE-II receptors for COVID-19 treatment by Molecular Docking Study, Arch. Microbiol
Hamulka, Jeruszka-Bielak, Górnicka, Dietary supplements during COVID-19 outbreak. results of google trends analysis supported by PLifeCOVID-19 online studies, Nutrients
Hawkins, Hires, Keenan, Aromatherapy Blend of Thyme, Orange, Clove Bud, and Frankincense Boosts Energy Levels in Post-COVID-19 Female Patients: A Randomized, Double-Blinded, Placebo Controlled Clinical Trial, Complement. Ther. Med, doi:10.1016/j.ctim.2022.102823
Islam, Ferdousi, Shahinozzaman, Previously published ethno-pharmacological reports reveal the potentiality of plants and plant-derived products used as traditional home remedies by Bangladeshi COVID-19 patients to combat SARS-CoV-2, Saudi J. Biol. Sci, doi:10.1016/j.sjbs.2021.07.036
Jafarzadeh, Jafarzadeh, Nemati, Therapeutic potential of ginger against COVID-19: Is there enough evidence?, J. Tradit. Chin. Med. Sci, doi:10.1016/j.jtcms.2021.10.001
Kaplan, The nanocomposites designs of phytomolecules from medicinal and aromatic plants: promising anticancer-antiviral applications, Beni. Suef. Univ. J. Basic Appl. Sci, doi:10.1186/s43088-022-00198-z
Khabour, Hassanein, Use of vitamin/zinc supplements, medicinal plants, and immune boosting drinks during COVID-19 pandemic: A pilot study from Benha city, Egypt, Heliyon, doi:10.1016/j.heliyon.2021.e06538
Khan, Sakib, Mahmud, Identification of potential phytochemicals from Citrus Limon against main protease of SARS-CoV-2: molecular docking, molecular dynamic simulations and quantum computations, J. Biomol. Struct. Dyn, doi:10.1080/07391102.2021.1947893
Koyama, Kondo, Ueha, Possible Use of Phytochemicals for Recovery from COVID-19-Induced Anosmia and Ageusia, Int. J. Mol. Sci, doi:10.3390/ijms22168912
Kumar, Pandey, Chemistry and biological activities of flavonoids: an overview, Sci. World J, doi:10.1155/2013/162750
Liu, Zheng, Cheng, Citrus fruits are rich in flavonoids for immunoregulation and potential targeting ACE2, Nat. Prod. Bioprospect
Magurano, Sucameli, Picone, Antioxidant Activity of Citrus Limonoids and Investigation of Their Virucidal Potential against SARS-CoV-2 in Cellular Models, doi:10.3390/antiox10111794
Malabadi, Meti, Chalannavar, Role of herbal medicine for controlling coronavirus (SARS-CoV-2) disease (COVID-19), International Journal of Research and Scientific Innovations
Milind, Deepa, Clove: a champion spice, Int. J. Res. Ayurveda Pharm
Naidu, Mustafa, Clemens, Plant-Derived Natural Non-Nucleoside Analog Inhibitors (NNAIs) against RNA-Dependent RNA Polymerase Complex (nsp7/nsp8/nsp12) of SARS-CoV-2, J. Diet Suppl, doi:10.1080/19390211.2021.2006387
Nimer, Khabour, Swedan, Natural Products Raw Data, doi:10.6084/m9.figshare.19758820.v2
Nimer, Khabour, Swedan, The impact of vitamin and mineral supplements usage prior to COVID-19 infection on disease severity and hospitalization, Bosn. J. Basic Med. Sci, doi:10.17305/bjbms.2021.7009
Nuertey, Addai, Kyei-Bafour, Home-Based Remedies to Prevent COVID-19-Associated Risk of Infection, Admission, Severe Disease, and Death: A Nested Case-Control Study, Evid. Based Complement. Alternat. Med
Nugraha, Ridwansyah, Ghozali, Traditional Herbal Medicine Candidates as Complementary Treatments for COVID-19: A Review of Their Mechanisms, Pros and Cons, Evid. Based Complement. Alternat. Med
Paidi, Raha, Eugenol, a Component of Holy Basil (Tulsi) and Common Spice Clove, Inhibits the Interaction Between SARS-CoV-2 Spike S1 and ACE2 to Induce Therapeutic Responses, J. Neuroimmune. Pharmacol, doi:10.1007/s11481-021-10028-1
Panyod, Ho, Sheen, Dietary therapy and herbal medicine for COVID-19 prevention: A review and perspective, J. Tradit. Complement. Med
Parasher, COVID-19: Current understanding of its pathophysiology, clinical presentation and treatment, Postgrad. Med. J
Pieroni, Vandebroek, Prakofjewa, Taming the pandemic? The importance of homemade plant-based foods and beverages as community responses to COVID-19, Springer
Refaat, Mady, Sarhan, Optimization and evaluation of propolis liposomes as a promising therapeutic approach for COVID-19, Int. J. Pharm, doi:10.1016/j.ijpharm.2020.120028
Sagnelli, Celia, Monari, Management of SARS-CoV-2 pneumonia, J. Med. Virol
Sen, Debnath, Debnath, Identification of potential inhibitors of SARS-CoV-2 main protease and spike receptor from 10 important spices through structure-based virtual screening and molecular dynamic study, J. Biomol. Struct. Dyn
Sengupta, Bhattacharyya, Kasle, Potential Immunomodulatory Properties of Biologically Active Components of Spices Against SARS-CoV-2 and Pan β-Coronaviruses, Front. Cell. Infect. Microbiol, doi:10.3389/fcimb.2021.729622
Sengupta, Sheorey, Hinge, Analgesic and antiinflammatory plants: an updated review, Int. J. Pharm. Sci. Rev. Res
Sharma, Shanavas, Natural derivatives with dual binding potential against SARS-CoV-2 main protease and human ACE2 possess low oral bioavailability: a brief computational analysis, J. Biomol. Struct. Dyn
Thiab, Nassar, Thiab, Medications and natural products used in Jordan for prevention or treatment of COVID-19 infection during the second wave of the pandemic: A cross-sectional online survey, Saudi Pharm. J, doi:10.1016/j.jsps.2022.03.006
Vahid, Rahmani, Can an anti-inflammatory diet be effective in preventing or treating viral respiratory diseases? A systematic narrative review, Clin. Nutr. ESPEN
Vandenbroucke, Elm, Altman, Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration, PLoS Med, doi:10.1371/journal.pmed.0040297
Vicidomini, Roviello, Roviello, Molecular Basis of the Therapeutical Potential of Clove (Syzygium aromaticum L.) and Clues to Its Anti-COVID-19 Utility, Molecules, doi:10.3390/molecules26071880
Wannes, Tounsi, Can medicinal plants contribute to the cure of Tunisian COVID-19 patients, J. Med. Plant
Who, Who, WHO Coronavirus (COVID-19) Dashboard
Wiersinga, Rhodes, Cheng, Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review, JAMA, doi:10.1001/jama.2020.12839
Wu, Lewis, Pae, Nutritional modulation of immune function: analysis of evidence, mechanisms, and clinical relevance, Front. Immunol, doi:10.3389/fimmu.2018.03160
Wu, Zhao, Yu, A new coronavirus associated with human respiratory disease in China, Nature, doi:10.1038/s41586-020-2008-3
Zaki, Evaluation of antioxidant and anti-lipid peroxidation potentials of Nigella sativa and onion extract on nicotineinduced lung damage, Folia Morphol. (Warsz), doi:10.5603/FM.a2018.0117
Zheng, SARS-CoV-2: an emerging coronavirus that causes a global threat, Int. J. Biol. Sci, doi:10.7150/ijbs.45053
Zhu, Zhou, Long, Variations of flavonoid composition and antioxidant properties among different cultivars, fruit tissues and developmental stages of citrus fruits, Chem. Biodivers, doi:10.1002/cbdv.201900690
Loading..
Please send us corrections, updates, or comments. Vaccines and
treatments are complementary. All practical, effective, and safe means should
be used based on risk/benefit analysis. No treatment, vaccine, or intervention
is 100% available and effective for all current and future variants. We do not
provide medical advice. Before taking any medication, consult a qualified
physician who can provide personalized advice and details of risks and
benefits based on your medical history and situation. FLCCC and WCH
provide treatment protocols.