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0 0.5 1 1.5 2+ Hospitalization 31% Improvement Relative Risk Severe case 13% Nimer et al. Curcumin for COVID-19 Prophylaxis Is prophylaxis with curcumin beneficial for COVID-19? Retrospective 2,148 patients in Jordan (March - July 2021) Lower hospitalization (p=0.08) and severe cases (p=0.47), not stat. sig. Nimer et al., F1000Research, doi:10.12688/f1000research.121933.1 Favors curcumin Favors control

Effect of natural products use prior to infection with COVID-19 on disease severity and hospitalization: A self-reported cross-sectional survey study

Nimer et al., F1000Research, doi:10.12688/f1000research.121933.1
Nimer et al., Effect of natural products use prior to infection with COVID-19 on disease severity and hospitalization: A.., F1000Research, doi:10.12688/f1000research.121933.1
Jun 2022   Source   PDF  
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Survey 2,148 COVID-19 recovered patients in Jordan, showing lower hospitalization with turmeric prophylaxis, not reaching statistical significance.
Although the 31% lower hospitalization is not statistically significant, it is consistent with the significant 25% lower hospitalization [15‑33%] from meta analysis of the 10 hospitalization results to date.
This is the 20th of 24 COVID-19 controlled studies for curcumin, which collectively show efficacy with p=0.000000053 (1 in 19 million). 19 studies are RCTs, which show efficacy with p=0.0000049.
risk of hospitalization, 30.8% lower, RR 0.69, p = 0.08, treatment 29 of 329 (8.8%), control 179 of 1,819 (9.8%), adjusted per study, odds ratio converted to relative risk, multivariable.
risk of severe case, 12.6% lower, RR 0.87, p = 0.47, treatment 40 of 329 (12.2%), control 211 of 1,819 (11.6%), adjusted per study, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Nimer et al., 10 Jun 2022, retrospective, Jordan, peer-reviewed, survey, mean age 40.2, 4 authors, study period March 2021 - July 2021.
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Effect of natural products use prior to infection with COVID-19 on disease severity and hospitalization: A self-reported cross-sectional survey study
Refat M Nimer, Omar F Khabour, Samer F Swedan, Hassan M Kofahi
F1000Research, doi:10.12688/f1000research.121933.1
Background: Managing coronavirus disease 2019 (COVID-19) using available resources is essential to reduce the health burden of disease. The severity of COVID-19 is affected by nutritional status. In this study the effect of natural product use prior to infection with COVID-19 on disease severity and hospitalization was explored. Methods: This was a cross-sectional study. Between March and July 2021, a self-administered survey was conducted in Jordan. Individuals who recovered from COVID-19 and were ≥18 years old were the study population. Study measures included the use of natural products, COVID-19 severity, and hospitalization status. A multivariate regression model was used for statistical analysis. Results: The mean age (mean ± SD) of the study sample (n=2,148) was 40.25 ± 15.58 years old. Multivariate logistic regression showed that the regular intake of carnation (OR [0.56], CI [0.37-0.85]), onion (OR [0.69], CI [0.52-0.92]), lemon (OR [0.68], CI [0.51-0.90]), and citrus fruits (OR [0.66], CI [0.50-0.89]) before infection were associated with a substantial reduction in COVID-19 severity (P<0.01). Also, the consumption of carnation (OR [0.55], CI [0.34-0.88]), lemon (OR [0.57], CI [0.42-0.78]), and citrus fruits (OR [0.61], CI [0.44-0.84]) were associated with a significant decrease in the frequency of COVID-19induced hospitalization (P<0.01). Conclusions: Regular consumption of carnation, lemon, and citrus fruits before infection was associated with better outcomes for COVID-19. Studies on other populations are required to confirm these findings.
Summary: The study explored the association between using specific natural products prior to COVID-19 infection and the severity of the disease and hospitalization status in a sample of Jordanian adults. Title: This is a retrospective study, the study design included a survey about prior COVID-19 infection and natural products consumption prior to infection. Methods: -Recruitment method is not clear, how the investigators reached out to the potential participants is not stated. The study suggests that only people who were previously infected with COVID-19 were included in the study. This assumption should be discussed in the inclusion criteria. -Calculation of the study sample assumed that the total population is the number of COVID-19 infected people as reported by the end of July 2021. Does this report include only adults or total confirmed cases? As the survey targeted only adults, the authors should identify precisely the study population as a reference for sample size calculation. Results: -Why is lemon considered a separate category from citrus? I suggest including all citrus fruit, including lemon as one category. -In table 1, the results were expressed in a different format, I suggest having all the results expressed as N (%). For this purpose, age can be categorized into 2-3 categories, and same for BMI. -In the multivariate logistic regression, the authors mentioned that after controlling for covariate, the findings... What are the covariates? The authors should..
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