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0 0.5 1 1.5 2+ Recovery, dyspnea -125% Improvement Relative Risk Recovery, ague -433% Recovery, weakness 73% Recovery, muscular pain 40% Recovery, headache 38% Recovery, sore throat -71% Recovery, sputum cough 12% Recovery, dry cough 0% Askari et al. IRCT20121216011763N46 Curcumin RCT EARLY Is early treatment with curcumin beneficial for COVID-19? Double-blind RCT 26 patients in Iran (November 2020 - April 2021) Worse recovery with curcumin (not stat. sig., p=0.58) Askari et al., Trials, doi:10.1186/s13063-022-06375-w Favors curcumin Favors control
The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, and inflammatory factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled trial
Askari et al., The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, and.., Trials, doi:10.1186/s13063-022-06375-w, IRCT20121216011763N46
Jun 2022   Source   PDF  
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Small RCT 46 outpatients in Iran, 23 treated with curcimin-piperine, showing no significant differences in recovery. 1000mg curcumin and 10mg piperine/day for 14 days.
risk of no recovery, 125.0% higher, RR 2.25, p = 0.58, treatment 3 of 8 (37.5%), control 1 of 6 (16.7%), dyspnea.
risk of no recovery, 433.3% higher, RR 5.33, p = 0.19, treatment 2 of 6 (33.3%), control 0 of 7 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), ague.
risk of no recovery, 72.9% lower, RR 0.27, p = 0.04, treatment 2 of 12 (16.7%), control 8 of 13 (61.5%), NNT 2.2, weakness.
risk of no recovery, 40.0% lower, RR 0.60, p = 0.42, treatment 3 of 10 (30.0%), control 7 of 14 (50.0%), NNT 5.0, muscular pain.
risk of no recovery, 38.5% lower, RR 0.62, p = 0.65, treatment 4 of 13 (30.8%), control 4 of 8 (50.0%), NNT 5.2, headache.
risk of no recovery, 71.4% higher, RR 1.71, p = 1.00, treatment 2 of 7 (28.6%), control 1 of 6 (16.7%), sore throat.
risk of no recovery, 12.5% lower, RR 0.88, p = 1.00, treatment 1 of 8 (12.5%), control 1 of 7 (14.3%), NNT 56, sputum cough.
risk of no recovery, no change, RR 1.00, p = 1.00, treatment 3 of 13 (23.1%), control 3 of 13 (23.1%), dry cough.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Askari et al., 6 Jun 2022, Double Blind Randomized Controlled Trial, placebo-controlled, Iran, peer-reviewed, 11 authors, study period November 2020 - April 2021, trial IRCT20121216011763N46.
Contact: (corresponding author).
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Abstract: (2022) 23:472 Askari et al. Trials Open Access RESEARCH The efficacy of curcumin‑piperine co‑supplementation on clinical symptoms, duration, severity, and inflammatory factors in COVID‑19 outpatients: a randomized double‑blind, placebo‑controlled trial Gholamreza Askari1,2,3, Amirhossein Sahebkar4,5,6, Davood Soleimani7, Atena Mahdavi3, Sahar Rafiee3, Muhammed Majeed8, Farzin Khorvash9, Bijan Iraj10, Mahshid Elyasi3, Mohammad Hossein Rouhani1 and Mohammad Bagherniya1,2,3*    Abstract Background: COVID-19 pandemic has made the disease a major global problem by creating a significant burden on health, economic, and social status. To date, there are no effective and approved medications for this disease. Curcumin as an anti-inflammatory agent can have a positive effect on the control of COVID-19 complications. This study aimed to assess the efficacy of curcumin-piperine supplementation on clinical symptoms, duration, severity, and inflammatory factors in patients with COVID-19. Methods: Forty-six outpatients with COVID-19 disease were randomly allocated to receive two capsules of curcumin-piperine; each capsule contained 500 mg curcumin plus 5 mg piperine or placebo for 14 days. Results: Mean changes in complete blood count, liver enzymes, blood glucose levels, lipid parameters, kidney function, and c-reactive protein (CRP) were not significantly different between the two groups. There was a significant improvement in health status, including dry cough, sputum cough, ague, sore throat, weakness, muscular pain, headache, and dyspnea at week 2 in both curcumin-piperine and placebo groups (P value < 0.05); however, the improvement in weakness was more in the curcumin-piperine group than with placebo group (P value 025). Conclusion: The present study results showed that curcumin-piperine co-supplementation in outpatients with COVID-19 could significantly reduce weakness. However, in this study, curcumin-piperine co-supplementation could not significantly affect the other indices, including biochemical and clinical indices. Trial registration: Iranian Registry of Clinical Trials IRCT2​01212​16011​763N46. 2020-10-31 Keywords: COVID-19, Curcumin, Piperine, Clinical trial, Clinical symptoms *Correspondence: 1 Food Security Research Center, Isfahan University of Medical Sciences, PO Box: 00983137922110, Isfahan, Iran Full list of author information is available at the end of the article
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