The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, and inflammatory factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled trial

{ 'indexed': {'date-parts': [[2022, 6, 6]], 'date-time': '2022-06-06T18:41:58Z', 'timestamp': 1654540918749}, 'reference-count': 71, 'publisher': 'Springer Science and Business Media LLC', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2022, 6, 6]], 'date-time': '2022-06-06T00:00:00Z', 'timestamp': 1654473600000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2022, 6, 6]], 'date-time': '2022-06-06T00:00:00Z', 'timestamp': 1654473600000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'funder': [ { 'DOI': '10.13039/501100003970', 'name': 'Isfahan University of Medical Sciences', 'doi-asserted-by': 'publisher', 'award': ['199014']}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2022, 12]]}, 'abstract': '<jats:title>Abstract</jats:title><jats:sec>\n' ' <jats:title>Background</jats:title>\n' ' <jats:p>COVID-19 pandemic has made the disease a major global problem by ' 'creating a significant burden on health, economic, and social status. To date, there are no ' 'effective and approved medications for this disease. Curcumin as an anti-inflammatory agent ' 'can have a positive effect on the control of COVID-19 complications. This study aimed to ' 'assess the efficacy of curcumin-piperine supplementation on clinical symptoms, duration, ' 'severity, and inflammatory factors in patients with COVID-19.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Methods</jats:title>\n' ' <jats:p>Forty-six outpatients with COVID-19 disease were randomly allocated ' 'to receive two capsules of curcumin-piperine; each capsule contained 500 mg curcumin plus 5 ' 'mg piperine or placebo for 14 days.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Results</jats:title>\n' ' <jats:p>Mean changes in complete blood count, liver enzymes, blood glucose ' 'levels, lipid parameters, kidney function, and c-reactive protein (CRP) were not ' 'significantly different between the two groups. There was a significant improvement in health ' 'status, including dry cough, sputum cough, ague, sore throat, weakness, muscular pain, ' 'headache, and dyspnea at week 2 in both curcumin-piperine and placebo groups ' '(<jats:italic>P</jats:italic> value &lt; 0.05); however, the improvement in weakness was more ' 'in the curcumin-piperine group than with placebo group (<jats:italic>P</jats:italic> value ' '025).</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Conclusion</jats:title>\n' ' <jats:p>The present study results showed that curcumin-piperine ' 'co-supplementation in outpatients with COVID-19 could significantly reduce weakness. However, ' 'in this study, curcumin-piperine co-supplementation could not significantly affect the other ' 'indices, including biochemical and clinical indices.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Trial registration</jats:title>\n' ' <jats:p>Iranian Registry of Clinical Trials <jats:ext-link ' 'xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" ' 'xlink:href="https://www.irct.ir/trial/47529">IRCT20121216011763N46</jats:ext-link>.\xa0' '2020-10-31</jats:p>\n' ' </jats:sec>', 'DOI': '10.1186/s13063-022-06375-w', 'type': 'journal-article', 'created': {'date-parts': [[2022, 6, 6]], 'date-time': '2022-06-06T06:02:29Z', 'timestamp': 1654495349000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, ' 'and inflammatory factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled ' 'trial', 'prefix': '10.1186', 'volume': '23', 'author': [ {'given': 'Gholamreza', 'family': 'Askari', 'sequence': 'first', 'affiliation': []}, {'given': 'Amirhossein', 'family': 'Sahebkar', 'sequence': 'additional', 'affiliation': []}, {'given': 'Davood', 'family': 'Soleimani', 'sequence': 'additional', 'affiliation': []}, {'given': 'Atena', 'family': 'Mahdavi', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sahar', 'family': 'Rafiee', 'sequence': 'additional', 'affiliation': []}, {'given': 'Muhammed', 'family': 'Majeed', 'sequence': 'additional', 'affiliation': []}, {'given': 'Farzin', 'family': 'Khorvash', 'sequence': 'additional', 'affiliation': []}, {'given': 'Bijan', 'family': 'Iraj', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mahshid', 'family': 'Elyasi', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mohammad Hossein', 'family': 'Rouhani', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-5861-6129', 'authenticated-orcid': False, 'given': 'Mohammad', 'family': 'Bagherniya', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2022, 6, 6]]}, 'reference': [ { 'key': '6375_CR1', 'doi-asserted-by': 'publisher', 'first-page': '71', 'DOI': '10.1016/j.ijsu.2020.02.034', 'volume': '76', 'author': 'C Sohrabi', 'year': '2020', 'unstructured': 'Sohrabi C, Alsafi Z, O’Neill N, Khan M, Kerwan A, Al-Jabir A, et al. 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In this ' 'study, we only reported the data obtained from COVID-19 outpatients. This trial ' 'was conducted in accordance with the principles of the Declaration of Helsinki. ' 'All patients were informed regarding the objectives and procedures of the ' 'trial, who then provided written informed consent.', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Ethics approval and consent to participate'}}, { 'value': 'Not applicable.', 'order': 3, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Consent for publication'}}, { 'value': 'MM is the funder of the Sami-Sabinsa Group. The other authors have nothing to ' 'disclose.', 'order': 4, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Competing interests'}}], 'article-number': '472'}