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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Recovery, dyspnea -125% Improvement Relative Risk Recovery, ague -433% Recovery, weakness 73% Recovery, muscular pain 40% Recovery, headache 38% Recovery, sore throat -71% Recovery, sputum cough 12% Recovery, dry cough 0% Curcumin  Askari et al.  EARLY TREATMENT  DB RCT Is early treatment with curcumin beneficial for COVID-19? Double-blind RCT 26 patients in Iran (November 2020 - April 2021) Worse recovery with curcumin (not stat. sig., p=0.58) c19early.org Askari et al., Trials, June 2022 Favors curcumin Favors control

The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, and inflammatory factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled trial

Jun 2022  
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Curcumin for COVID-19
14th treatment shown to reduce risk in February 2021
 
*, now known with p = 0.000000046 from 26 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
Small RCT 46 outpatients in Iran, 23 treated with curcimin-piperine, showing no significant differences in recovery. 1000mg curcumin and 10mg piperine/day for 14 days.
This is the 14th of 20 COVID-19 RCTs for curcumin, which collectively show efficacy with p=0.0000093.
This is the 19th of 26 COVID-19 controlled studies for curcumin, which collectively show efficacy with p=0.000000046 (1 in 22 million).
risk of no recovery, 125.0% higher, RR 2.25, p = 0.58, treatment 3 of 8 (37.5%), control 1 of 6 (16.7%), dyspnea.
risk of no recovery, 433.3% higher, RR 5.33, p = 0.19, treatment 2 of 6 (33.3%), control 0 of 7 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), ague.
risk of no recovery, 72.9% lower, RR 0.27, p = 0.04, treatment 2 of 12 (16.7%), control 8 of 13 (61.5%), NNT 2.2, weakness.
risk of no recovery, 40.0% lower, RR 0.60, p = 0.42, treatment 3 of 10 (30.0%), control 7 of 14 (50.0%), NNT 5.0, muscular pain.
risk of no recovery, 38.5% lower, RR 0.62, p = 0.65, treatment 4 of 13 (30.8%), control 4 of 8 (50.0%), NNT 5.2, headache.
risk of no recovery, 71.4% higher, RR 1.71, p = 1.00, treatment 2 of 7 (28.6%), control 1 of 6 (16.7%), sore throat.
risk of no recovery, 12.5% lower, RR 0.88, p = 1.00, treatment 1 of 8 (12.5%), control 1 of 7 (14.3%), NNT 56, sputum cough.
risk of no recovery, no change, RR 1.00, p = 1.00, treatment 3 of 13 (23.1%), control 3 of 13 (23.1%), dry cough.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Askari et al., 6 Jun 2022, Double Blind Randomized Controlled Trial, placebo-controlled, Iran, peer-reviewed, 11 authors, study period November 2020 - April 2021, trial IRCT20121216011763N46. Contact: baghrerniya@nutr.mui.ac.ir (corresponding author).
This PaperCurcuminAll
The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, and inflammatory factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled trial
Gholamreza Askari, Amirhossein Sahebkar, Davood Soleimani, Atena Mahdavi, Sahar Rafiee, Muhammed Majeed, Farzin Khorvash, Bijan Iraj, Mahshid Elyasi, Mohammad Hossein Rouhani, Mohammad Bagherniya
Trials, doi:10.1186/s13063-022-06375-w
Background: COVID-19 pandemic has made the disease a major global problem by creating a significant burden on health, economic, and social status. To date, there are no effective and approved medications for this disease. Curcumin as an anti-inflammatory agent can have a positive effect on the control of COVID-19 complications. This study aimed to assess the efficacy of curcumin-piperine supplementation on clinical symptoms, duration, severity, and inflammatory factors in patients with COVID-19. Methods: Forty-six outpatients with COVID-19 disease were randomly allocated to receive two capsules of curcumin-piperine; each capsule contained 500 mg curcumin plus 5 mg piperine or placebo for 14 days. Results: Mean changes in complete blood count, liver enzymes, blood glucose levels, lipid parameters, kidney function, and c-reactive protein (CRP) were not significantly different between the two groups. There was a significant improvement in health status, including dry cough, sputum cough, ague, sore throat, weakness, muscular pain, headache, and dyspnea at week 2 in both curcumin-piperine and placebo groups (P value < 0.05); however, the improvement in weakness was more in the curcumin-piperine group than with placebo group (P value 025). Conclusion: The present study results showed that curcumin-piperine co-supplementation in outpatients with COVID-19 could significantly reduce weakness. However, in this study, curcumin-piperine co-supplementation could not significantly affect the other indices, including biochemical and clinical indices.
Authors' contributions Study design: GA, AS, BI, MHR, and MB. Data gathering: DS, AM, SR, FK, and ME. Statistical analysis: GA, DS, BI, MHR, and MB. Drafting the manuscript: GA, AS, AM, SR, MM, ME, and MB. The authors read and approved the final manuscript before submission. Declarations Ethics approval and consent to participate This trial was accepted by the ethics committee of the Isfahan University of Medical Sciences, with the ethical code: IR.MUI.MED.REC.1399.049. In this study, we only reported the data obtained from COVID-19 outpatients. This trial was conducted in accordance with the principles of the Declaration of Helsinki. All patients were informed regarding the objectives and procedures of the trial, who then provided written informed consent. Consent for publication Not applicable. Competing interests MM is the funder of the Sami-Sabinsa Group. The other authors have nothing to disclose. Author details 1 Food Security Research Center, Isfahan University of Medical Sciences, PO Box: 00983137922110, Isfahan, Iran. 2 Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 3 Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. 4 Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. 5 Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad,..
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{ 'DOI': '10.1186/s13063-022-06375-w', 'ISSN': ['1745-6215'], 'URL': 'http://dx.doi.org/10.1186/s13063-022-06375-w', 'abstract': '<jats:title>Abstract</jats:title><jats:sec>\n' ' <jats:title>Background</jats:title>\n' ' <jats:p>COVID-19 pandemic has made the disease a major global problem by ' 'creating a significant burden on health, economic, and social status. To date, there are no ' 'effective and approved medications for this disease. Curcumin as an anti-inflammatory agent ' 'can have a positive effect on the control of COVID-19 complications. This study aimed to ' 'assess the efficacy of curcumin-piperine supplementation on clinical symptoms, duration, ' 'severity, and inflammatory factors in patients with COVID-19.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Methods</jats:title>\n' ' <jats:p>Forty-six outpatients with COVID-19 disease were randomly allocated ' 'to receive two capsules of curcumin-piperine; each capsule contained 500 mg curcumin plus 5 ' 'mg piperine or placebo for 14 days.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Results</jats:title>\n' ' <jats:p>Mean changes in complete blood count, liver enzymes, blood glucose ' 'levels, lipid parameters, kidney function, and c-reactive protein (CRP) were not ' 'significantly different between the two groups. There was a significant improvement in health ' 'status, including dry cough, sputum cough, ague, sore throat, weakness, muscular pain, ' 'headache, and dyspnea at week 2 in both curcumin-piperine and placebo groups ' '(<jats:italic>P</jats:italic> value &lt; 0.05); however, the improvement in weakness was more ' 'in the curcumin-piperine group than with placebo group (<jats:italic>P</jats:italic> value ' '025).</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Conclusion</jats:title>\n' ' <jats:p>The present study results showed that curcumin-piperine ' 'co-supplementation in outpatients with COVID-19 could significantly reduce weakness. However, ' 'in this study, curcumin-piperine co-supplementation could not significantly affect the other ' 'indices, including biochemical and clinical indices.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Trial registration</jats:title>\n' ' <jats:p>Iranian Registry of Clinical Trials <jats:ext-link ' 'xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" ' 'xlink:href="https://www.irct.ir/trial/47529">IRCT20121216011763N46</jats:ext-link>.\xa0' '2020-10-31</jats:p>\n' ' </jats:sec>', 'alternative-id': ['6375'], 'article-number': '472', 'assertion': [ { 'group': {'label': 'Article History', 'name': 'ArticleHistory'}, 'label': 'Received', 'name': 'received', 'order': 1, 'value': '29 August 2021'}, { 'group': {'label': 'Article History', 'name': 'ArticleHistory'}, 'label': 'Accepted', 'name': 'accepted', 'order': 2, 'value': '2 May 2022'}, { 'group': {'label': 'Article History', 'name': 'ArticleHistory'}, 'label': 'First Online', 'name': 'first_online', 'order': 3, 'value': '6 June 2022'}, {'group': {'label': 'Declarations', 'name': 'EthicsHeading'}, 'name': 'Ethics', 'order': 1}, { 'group': {'label': 'Ethics approval and consent to participate', 'name': 'EthicsHeading'}, 'name': 'Ethics', 'order': 2, 'value': 'This trial was accepted by the ethics committee of the Isfahan University of ' 'Medical Sciences, with the ethical code: IR.MUI.MED.REC.1399.049. In this ' 'study, we only reported the data obtained from COVID-19 outpatients. This trial ' 'was conducted in accordance with the principles of the Declaration of Helsinki. ' 'All patients were informed regarding the objectives and procedures of the ' 'trial, who then provided written informed consent.'}, { 'group': {'label': 'Consent for publication', 'name': 'EthicsHeading'}, 'name': 'Ethics', 'order': 3, 'value': 'Not applicable.'}, { 'group': {'label': 'Competing interests', 'name': 'EthicsHeading'}, 'name': 'Ethics', 'order': 4, 'value': 'MM is the funder of the Sami-Sabinsa Group. 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Elevated red blood cell ' 'distribution width is associated with morphometric vertebral fracture in ' 'community-dwelling older adults, independent of anemia, inflammation, ' 'and nutritional status: the Korean Urban Rural Elderly (KURE) study. ' 'Calcif Tissue Int. 2019;104(1):26–33. ' 'https://doi.org/10.1007/s00223-018-0470-9.', 'volume': '104', 'year': '2019'}, { 'DOI': '10.15420/cfr.2019.13.1', 'author': 'A García-Escobar', 'doi-asserted-by': 'publisher', 'first-page': '176', 'issue': '3', 'journal-title': 'Card Fail Rev', 'key': '6375_CR55', 'unstructured': 'García-Escobar A, Grande Ingelmo JM. Red cell volume distribution width ' 'as another biomarker. Card Fail Rev. 2019;5(3):176–9. ' 'https://doi.org/10.15420/cfr.2019.13.1.', 'volume': '5', 'year': '2019'}, { 'DOI': '10.1111/ijlh.12082', 'author': 'J Ford', 'doi-asserted-by': 'publisher', 'first-page': '351', 'issue': '3', 'journal-title': 'Int J Lab Hematol', 'key': '6375_CR56', 'unstructured': 'Ford J. 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