The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, and inflammatory factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled trial

DOI record: { "DOI": "10.1186/s13063-022-06375-w", "ISSN": [ "1745-6215" ], "URL": "http://dx.doi.org/10.1186/s13063-022-06375-w", "abstract": "<jats:title>Abstract</jats:title><jats:sec>\n <jats:title>Background</jats:title>\n <jats:p>COVID-19 pandemic has made the disease a major global problem by creating a significant burden on health, economic, and social status. To date, there are no effective and approved medications for this disease. Curcumin as an anti-inflammatory agent can have a positive effect on the control of COVID-19 complications. This study aimed to assess the efficacy of curcumin-piperine supplementation on clinical symptoms, duration, severity, and inflammatory factors in patients with COVID-19.</jats:p>\n </jats:sec><jats:sec>\n <jats:title>Methods</jats:title>\n <jats:p>Forty-six outpatients with COVID-19 disease were randomly allocated to receive two capsules of curcumin-piperine; each capsule contained 500 mg curcumin plus 5 mg piperine or placebo for 14 days.</jats:p>\n </jats:sec><jats:sec>\n <jats:title>Results</jats:title>\n <jats:p>Mean changes in complete blood count, liver enzymes, blood glucose levels, lipid parameters, kidney function, and c-reactive protein (CRP) were not significantly different between the two groups. There was a significant improvement in health status, including dry cough, sputum cough, ague, sore throat, weakness, muscular pain, headache, and dyspnea at week 2 in both curcumin-piperine and placebo groups (<jats:italic>P</jats:italic> value &lt; 0.05); however, the improvement in weakness was more in the curcumin-piperine group than with placebo group (<jats:italic>P</jats:italic> value 025).</jats:p>\n </jats:sec><jats:sec>\n <jats:title>Conclusion</jats:title>\n <jats:p>The present study results showed that curcumin-piperine co-supplementation in outpatients with COVID-19 could significantly reduce weakness. However, in this study, curcumin-piperine co-supplementation could not significantly affect the other indices, including biochemical and clinical indices.</jats:p>\n </jats:sec><jats:sec>\n <jats:title>Trial registration</jats:title>\n <jats:p>Iranian Registry of Clinical Trials <jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"uri\" xlink:href=\"https://www.irct.ir/trial/47529\">IRCT20121216011763N46</jats:ext-link>. 2020-10-31</jats:p>\n </jats:sec>", "alternative-id": [ "6375" ], "article-number": "472", "assertion": [ { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Received", "name": "received", "order": 1, "value": "29 August 2021" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Accepted", "name": "accepted", "order": 2, "value": "2 May 2022" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "First Online", "name": "first_online", "order": 3, "value": "6 June 2022" }, { "group": { "label": "Declarations", "name": "EthicsHeading" }, "name": "Ethics", "order": 1 }, { "group": { "label": "Ethics approval and consent to participate", "name": "EthicsHeading" }, "name": "Ethics", "order": 2, "value": "This trial was accepted by the ethics committee of the Isfahan University of Medical Sciences, with the ethical code: IR.MUI.MED.REC.1399.049. In this study, we only reported the data obtained from COVID-19 outpatients. This trial was conducted in accordance with the principles of the Declaration of Helsinki. All patients were informed regarding the objectives and procedures of the trial, who then provided written informed consent." }, { "group": { "label": "Consent for publication", "name": "EthicsHeading" }, "name": "Ethics", "order": 3, "value": "Not applicable." }, { "group": { "label": "Competing interests", "name": "EthicsHeading" }, "name": "Ethics", "order": 4, "value": "MM is the funder of the Sami-Sabinsa Group. The other authors have nothing to disclose." } ], "author": [ { "affiliation": [], "family": "Askari", "given": "Gholamreza", "sequence": "first" }, { "affiliation": [], "family": "Sahebkar", "given": "Amirhossein", "sequence": "additional" }, { "affiliation": [], "family": "Soleimani", "given": "Davood", "sequence": "additional" }, { "affiliation": [], "family": "Mahdavi", "given": "Atena", "sequence": "additional" }, { "affiliation": [], "family": "Rafiee", "given": "Sahar", "sequence": "additional" }, { "affiliation": [], "family": "Majeed", "given": "Muhammed", "sequence": "additional" }, { "affiliation": [], "family": "Khorvash", "given": "Farzin", "sequence": "additional" }, { "affiliation": [], "family": "Iraj", "given": "Bijan", "sequence": "additional" }, { "affiliation": [], "family": "Elyasi", "given": "Mahshid", "sequence": "additional" }, { "affiliation": [], "family": "Rouhani", "given": "Mohammad Hossein", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0002-5861-6129", "affiliation": [], "authenticated-orcid": false, "family": "Bagherniya", "given": "Mohammad", "sequence": "additional" } ], "container-title": "Trials", "container-title-short": "Trials", "content-domain": { "crossmark-restriction": false, "domain": [ "link.springer.com" ] }, "created": { "date-parts": [ [ 2022, 6, 6 ] ], "date-time": "2022-06-06T06:02:29Z", "timestamp": 1654495349000 }, "deposited": { "date-parts": [ [ 2022, 6, 6 ] ], "date-time": "2022-06-06T18:06:16Z", "timestamp": 1654538776000 }, "funder": [ { "DOI": "10.13039/501100003970", "award": [ "199014" ], "doi-asserted-by": "publisher", "name": "Isfahan University of Medical Sciences" } ], "indexed": { "date-parts": [ [ 2022, 6, 6 ] ], "date-time": "2022-06-06T18:41:58Z", "timestamp": 1654540918749 }, "is-referenced-by-count": 0, "issue": "1", "issued": { "date-parts": [ [ 2022, 6, 6 ] ] }, "journal-issue": { "issue": "1", "published-print": { "date-parts": [ [ 2022, 12 ] ] } }, "language": "en", "license": [ { "URL": "https://creativecommons.org/licenses/by/4.0", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2022, 6, 6 ] ], "date-time": "2022-06-06T00:00:00Z", "timestamp": 1654473600000 } }, { "URL": "https://creativecommons.org/licenses/by/4.0", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2022, 6, 6 ] ], "date-time": "2022-06-06T00:00:00Z", "timestamp": 1654473600000 } } ], "link": [ { "URL": "https://link.springer.com/content/pdf/10.1186/s13063-022-06375-w.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://link.springer.com/article/10.1186/s13063-022-06375-w/fulltext.html", "content-type": "text/html", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://link.springer.com/content/pdf/10.1186/s13063-022-06375-w.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "297", "original-title": [], "prefix": "10.1186", "published": { "date-parts": [ [ 2022, 6, 6 ] ] }, "published-online": { "date-parts": [ [ 2022, 6, 6 ] ] }, "published-print": { "date-parts": [ [ 2022, 12 ] ] }, "publisher": "Springer Science and Business Media LLC", "reference": [ { "DOI": "10.1016/j.ijsu.2020.02.034", "author": "C Sohrabi", "doi-asserted-by": "publisher", "first-page": "71", "journal-title": "Int J Surg (London, England)", "key": "6375_CR1", "unstructured": "Sohrabi C, Alsafi Z, O’Neill N, Khan M, Kerwan A, Al-Jabir A, et al. 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