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Effectiveness of Curcumin on Outcomes of Hospitalized COVID-19 Patients: A Systematic Review of Clinical Trials

Vahedian-Azimi et al., Nutrients, doi:10.3390/nu14020256
Jan 2022  
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Curcumin for COVID-19
14th treatment shown to reduce risk in February 2021
*, now known with p = 0.000000046 from 26 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Review of 6 COVID-19 curcumin studies showing that treatment resulted in significant improvement in symptoms, duration of hospitalization, and mortality, and a significant decrease in proinflammatory cytokines and increase in anti-inflammatory cytokines.
4 meta analyses show significant improvements with curcumin for mortality Kow, Shafiee, Shojaei, Vahedian-Azimi, hospitalization Shojaei, Vahedian-Azimi, recovery Shafiee, and symptoms Vahedian-Azimi.
Vahedian-Azimi et al., 7 Jan 2022, peer-reviewed, 9 authors.
This PaperCurcuminAll
Effectiveness of Curcumin on Outcomes of Hospitalized COVID-19 Patients: A Systematic Review of Clinical Trials
Amir Vahedian-Azimi, Mitra Abbasifard, Farshid Rahimi-Bashar, Paul C Guest, Muhammed Majeed, Asadollah Mohammadi, Maciej Banach, Tannaz Jamialahmadi, Amirhossein Sahebkar
Nutrients, doi:10.3390/nu14020256
Despite the ongoing vaccination efforts, there is still an urgent need for safe and effective treatments to help curb the debilitating effects of COVID-19 disease. This systematic review aimed to investigate the efficacy of supplemental curcumin treatment on clinical outcomes and inflammationrelated biomarker profiles in COVID-19 patients. We searched PubMed, Scopus, Web of Science, EMBASE, ProQuest, and Ovid databases up to 30 June 2021 to find studies that assessed the effects of curcumin-related compounds in mild to severe COVID-19 patients. Six studies were identified which showed that curcumin supplementation led to a significant decrease in common symptoms, duration of hospitalization and deaths. In addition, all of these studies showed that the intervention led to amelioration of cytokine storm effects thought to be a driving force in severe COVID-19 cases. This was seen as a significant (p < 0.05) decrease in proinflammatory cytokines such as IL1β and IL6, with a concomitant significant (p < 0.05) increase in anti-inflammatory cytokines, including IL-10, IL-35 and TGF-α. Taken together, these findings suggested that curcumin exerts its beneficial effects through at least partial restoration of pro-inflammatory/anti-inflammatory balance. In conclusion, curcumin supplementation may offer an efficacious and safe option for improving COVID-19 disease outcomes. We highlight the point that future clinical studies of COVID-19 disease should employ larger cohorts of patients in different clinical settings with standardized preparations of curcuminrelated compounds.
Supplementary Materials: The following supporting information can be downloaded at: https: //, Supplementary File S1. Details of search strategy; Supplementary File S2. Methodological quality assessment for RCTs included studies using the Jadad rating scale.
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