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All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Mortality 77% Improvement Relative Risk Kow et al. Curcumin for COVID-19 META ANALYSIS Favors curcumin Favors control
The effect of curcumin on the risk of mortality in patients with COVID-19: A systematic review and meta-analysis of randomized trials
Kow et al., Phytotherapy Research, doi:10.1002/ptr.7468
Kow et al., The effect of curcumin on the risk of mortality in patients with COVID-19: A systematic review and.., Phytotherapy Research, doi:10.1002/ptr.7468
Apr 2022   Source   PDF  
  All Studies   Meta
Meta analysis of 3 curcumin RCTs showing lower mortality with treatment. Author notes the small sample sizes of the included trials.
Currently there are 24 curcumin studies and meta analysis shows:
Mortality63% lower [35‑79%]
Ventilation77% lower [-6‑95%]
ICU admission67% lower [-211‑96%]
Hospitalization25% lower [15‑33%]
risk of death, 77.0% lower, OR 0.23, p = 0.002, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kow et al., 28 Apr 2022, peer-reviewed, 3 authors.
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This PaperCurcuminAll
The effect of curcumin on the risk of mortality in patients with COVID ‐19: A systematic review and meta‐analysis of randomized trials
Chia Siang Kow, Dinesh Sangarran Ramachandram, Syed Shahzad Hasan
Phytotherapy Research, doi:10.1002/ptr.7468
The coronavirus disease 2019 (COVID-19) pandemic is far from bygone, with the emergence of newer variations of concern of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While the worldwide vaccine rollout has progressed at a breakneck pace, the hunt for new safe, effective, and targeted treatments should continue in parallel due to the frequent occurrence of breakthrough cases. Curcumin is one such natural polyphenolic compound with multiple benefits, including antiviral, anti-inflammatory, anticoagulant, antiplatelet,
CONFLICT OF INTEREST The authors declare no conflict of interest.
Dourado, Freire, Pereira, Amaral-Machado, Alencar et al., Will curcumin nanosystems be the next promising antiviral alternatives in COVID-19 treatment trials?, Biomedicine & Pharmacotherapy
Han, The effects of black pepper on the intestinal absorption and hepatic metabolism of drugs, Expert Opinion on Drug Metabolism & Toxicology
Hassaniazad, Eftekhar, Inchehsablagh, Kamali, Tousi et al., A triple-blind, placebo-controlled, randomized clinical trial to evaluate the effect of curcumin-containing nanomicelles on cellular immune responses subtypes and clinical outcome in COVID-19 patients, Phytotherapy Research
Manoharan, Haridas, Vasanthakumar, Muthu, Thavoorullah et al., Curcumin: A wonder drug as a preventive measure for COVID19 management, Indian Journal of Clinical Biochemistry
Pawar, Mastud, Pawar, Pawar, Bhoite et al., Oral curcumin with Piperine as adjuvant therapy for the treatment of COVID-19: A randomized clinical trial, Frontiers in Pharmacology
Rattis, Ramos, Celes, Curcumin as a potential treatment for COVID-19, Frontiers in Pharmacology
Soni, Mehta, Ratre, Tiwari, Amit et al., Curcumin, a traditional spice component, can hold the promise against COVID-19?, European Journal of Pharmacology
Sterne, Savovi C, Page, Elbers, Blencowe et al., RoB 2: A revised tool for assessing risk of bias in randomised trials, BMJ (Clinical Research Ed)
Tahmasebi, El-Esawi, Mahmoud, Timoshin, Valizadeh et al., Immunomodulatory effects of nanocurcumin on Th17 cell responses in mild and severe COVID-19 patients, Journal of Cellular Physiology
Valizadeh, Abdolmohammadi-Vahid, Danshina, Ziya Gencer, Ammari et al., Nano-curcumin therapy, a promising method in modulating inflammatory cytokines in COVID-19 patients, International Immunopharmacology
Yin, Guo, Li, Tang, Li et al., Curcumin suppresses IL-1β secretion and prevents inflammation through inhibition of the NLRP3 inflammasome, Journal of Immunology
Zahedipour, Hosseini, Sathyapalan, Majeed, Jamialahmadi et al., Potential effects of curcumin in the treatment of COVID-19 infection, Phytotherapy Research
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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