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Curcumin for the treatment of COVID-19 patients: A meta-analysis of randomized controlled trials

Shafiee et al., Phytotherapy Research, doi:10.1002/ptr.7724, Jan 2023

Curcumin for COVID-19

16th treatment shown to reduce risk in February 2021, now with p = 0.0000000061 from 28 studies.
Lower risk for mortality, ventilation, hospitalization, progression, recovery, and viral clearance.

No treatment is 100% effective.
Protocols combine treatments.

6,700+ studies · 220+ treatments

c19early.org
Meta-analysis
Meta analysis of 13 curcumin RCTs showing lower mortality with treatment. Authors note that subgroup analysis suggested improved efficacy with early treatment and with combined treatment.
6 meta-analyses show significant improvements with curcumin for mortality1-6, mechanical ventilation6, hospitalization1,4, recovery3,6, progression6, and symptoms1.
Currently there are 28 curcumin for COVID-19 studies, showing 63% lower mortality [36‑78%], 80% lower ventilation [25‑95%], 78% lower ICU admission [-27‑96%], and 27% lower hospitalization [18‑34%].
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OutcomeImprovementEffect · pTreatmentControl
risk of death 62.0% lower · RR 0.38 · p = 0.003** 62.0% lowerRR 0.38p = 0.003** ,

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates. ** p < 0.01

Shafiee et al., 14 Jan 2023, peer-reviewed, 7 authors.
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