Nanocurcumin improves Treg cell responses in patients with mild and severe SARS-CoV2
et al., Life Sciences, doi:10.1016/j.lfs.2021.119437
, Nanocurcumin improves Treg cell responses in patients with mild and severe SARS-CoV2, Life Sciences, doi:10.1016/j.lfs.2021.119437
RCT 40 hospitalized, 40 ICU, and 40 control patients in Iran, showing lower mortality and improved regulatory T cell responses with nanocurcumin treatment (SinaCurcumin).This is the 3rd of 19 COVID-19 RCTs for curcumin, which collectively show efficacy with p=0.0000049.This is the 4th of 24 COVID-19 controlled studies for curcumin, which collectively show efficacy with p=0.000000053 (1 in 19 million).
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risk of death, 83.3% lower, RR 0.17, p = 0.11, treatment 1 of 40 (2.5%), control 6 of 40 (15.0%), NNT 8.0.
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risk of death, 66.7% lower, RR 0.33, p = 1.00, treatment 0 of 20 (0.0%), control 1 of 20 (5.0%), NNT 20, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), non-ICU patients.
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risk of death, 80.0% lower, RR 0.20, p = 0.18, treatment 1 of 20 (5.0%), control 5 of 20 (25.0%), NNT 5.0, ICU patients.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Tahmasebi et al., 28 Mar 2021, Double Blind Randomized Controlled Trial, Iran, peer-reviewed, 14 authors.
Nanocurcumin improves Treg cell responses in patients with mild and severe SARS-CoV2
Life Sciences, doi:10.1016/j.lfs.2021.119437
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre -including this research content -immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
Declaration of competing interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be considered as a potential conflict of interest.
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