Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All curcumin studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchCurcuminCurcumin (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Curcumin as a Potential Treatment for COVID-19

Rattis et al., Frontiers in Pharmacology, doi:10.3389/fphar.2021.675287
May 2021  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Curcumin for COVID-19
14th treatment shown to reduce risk in February 2021
 
*, now known with p = 0.000000046 from 26 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
Review of curcumin for COVID-19 including potential antiviral, anti-inflammatory, anticoagulant, antiplatelet, and cytoprotective effects.
Reviews covering curcumin for COVID-19 include Arab, Daskou, Halma, Hegde, Hulscher, Kali, Kritis, Law, Rattis, Vajdi, Yong.
Rattis et al., 7 May 2021, peer-reviewed, 3 authors.
This PaperCurcuminAll
Curcumin as a Potential Treatment for COVID-19
Bruna A C Rattis, Simone G Ramos, Mara R N Celes
Frontiers in Pharmacology, doi:10.3389/fphar.2021.675287
Coronavirus disease 2019 (COVID-19 ) is an infectious disease that rapidly spread throughout the world leading to high mortality rates. Despite the knowledge of previous diseases caused by viruses of the same family, such as MERS and SARS-CoV, management and treatment of patients with COVID-19 is a challenge. One of the best strategies around the world to help combat the COVID-19 has been directed to drug repositioning; however, these drugs are not specific to this new virus. Additionally, the pathophysiology of COVID-19 is highly heterogeneous, and the way of SARS-CoV-2 modulates the different systems in the host remains unidentified, despite recent discoveries. This complex and multifactorial response requires a comprehensive therapeutic approach, enabling the integration and refinement of therapeutic responses of a given single compound that has several action potentials. In this context, natural compounds, such as Curcumin, have shown beneficial effects on the progression of inflammatory diseases due to its numerous action mechanisms: antiviral, antiinflammatory, anticoagulant, antiplatelet, and cytoprotective. These and many other effects of curcumin make it a promising target in the adjuvant treatment of COVID-19. Hence, the purpose of this review is to specifically point out how curcumin could interfere at different times/points during the infection caused by SARS-CoV-2, providing a substantial contribution of curcumin as a new adjuvant therapy for the treatment of COVID-19.
AUTHOR CONTRIBUTIONS BR: Conceptualization, Writing-original draft, author of illustrations. SR: Conceptualization, Writing-review and editing, Funding acquisition. MC: Conceptualization, Writing-review and editing, Funding acquisition, Supervision. Conflict of Interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References
Alexandrow, Song, Altiok, Gray, Haura et al., None, Curcumin. Eur. J. Cancer Prev, doi:10.1097/CEJ.0b013e32834ef194
Ali, Banerjea, Curcumin Inhibits HIV-1 by Promoting Tat Protein Degradation, Sci. Rep, doi:10.1038/srep27539
Almatroodi, Alrumaihi, Alsahli, Alhommrani, Khan et al., Curcumin, an Active Constituent of Turmeric Spice: Implication in the Prevention of Lung Injury Induced by Benzo(a) Pyrene (BAP) in Rats, Molecules, doi:10.3390/molecules25030724
Amirfakhryan, Safari, Outbreak of SARS-CoV2: Pathogenesis of Infection and Cardiovascular Involvement, Hellenic J. Cardiol, doi:10.1016/j.hjc.2020.05.007
Anand, Ziebuhr, Wadhwani, Mesters, Hilgenfeld, Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of Anti-SARS Drugs, Science, doi:10.1126/science.1085658
Anggakusuma, Schang, Rachmawati, Frentzen, Pfaender et al., Turmeric Curcumin Inhibits Entry of All Hepatitis C Virus Genotypes into Human Liver Cells, Gut, doi:10.1136/gutjnl-2012-304299
Antoine, Simard, Girard, Curcumin Inhibits Agent-Induced Human Neutrophil Functions In Vitro and Lipopolysaccharide-Induced Neutrophilic Infiltration In Vivo, Int. Immunopharmacology, doi:10.1016/j.intimp.2013.09.024
Ashry, Gameil, Suddek, Modulation of Cyclophosphamide-Induced Early Lung Injury by Allicin, Pharm. Biol, doi:10.3109/13880209.2013.766895
Aslam, Ladilov, Targeting the sAC-dependent cAMP Pool to Prevent SARS-Cov-2 Infection, Cells, doi:10.3390/cells9091962
Babaei, Nassiri-Asl, Hosseinzadeh, Curcumin (A Constituent of Turmeric): New Treatment Option against COVID-19, Food Sci. Nutr, doi:10.1002/fsn3.1858
Balasubramanian, Pilankatta, Teramoto, Sajith, Nwulia et al., Inhibition of Dengue Virus by Curcuminoids, Antiviral Res, doi:10.1016/j.antiviral.2018.12.002
Beck, Shin, Choi, Park, Kang, Predicting Commercially Available Antiviral Drugs that May Act on the Novel Coronavirus (SARS-CoV-2) through a Drug-Target Interaction Deep Learning Model, Comput. Struct. Biotechnol. J, doi:10.1016/j.csbj.2020.03.025
Beevers, Chen, Liu, Luo, Webster et al., Curcumin Disrupts the Mammalian Target of Rapamycin-Raptor Complex, Cancer Res, doi:10.1158/0008-5472.CAN-08-2367
Beevers, Li, Liu, Huang, Curcumin Inhibits the Mammalian Target of Rapamycin-Mediated Signaling Pathways in Cancer Cells, Int. J. Cancer, doi:10.1002/ijc.21932
Bonaventura, Liberale, Carbone, Vecchié, Diaz-Cañestro et al., The Pathophysiological Role of Neutrophil Extracellular Traps in Inflammatory Diseases, Thromb. Haemost, doi:10.1160/TH17-09-0630
Butenas, Orfeo, Mann, Tissue Factor Activity and Function in Blood Coagulation, Thromb. Res, doi:10.1016/S0049-3848(08)70018-5
Carvalho-Schneider, Laurent, Lemaignen, Beaufils, Bourbao-Tournois et al., Follow-up of Adults with Noncritical COVID-19 Two Months after Symptom Onset, Clin. Microbiol. Infect, doi:10.1016/j.cmi.2020.09.052
Chai, -S, Chen, Lin, Xie et al., Curcumin Regulates the Differentiation of Naïve CD4+T Cells and Activates IL-10 Immune Modulation against Acute Lung Injury in Mice, Biomed. Pharmacother, doi:10.1016/j.biopha.2020.109946
Chan, Kok, Zhu, Chu, To et al., Genomic Characterization of the 2019 Novel Human-Pathogenic Coronavirus Isolated from a Patient with Atypical Pneumonia after Visiting Wuhan, Emerging Microbes Infect, doi:10.1080/22221751.2020.1719902
Cheemanapalli, Chinthakunta, Shaikh, Shivaranjani, Pamuru et al., Comparative Binding Studies of Curcumin and Tangeretin on Up-Stream Elements of NF-kB Cascade: a Combined Molecular Docking Approach, Netw. Model. Anal. Health Inform. Bioinforma, doi:10.1007/s13721-019-0196-2
Chen, Kuo, Chai, Ou, Yang, Pretreatment of Curcumin Attenuates Coagulopathy and Renal Injury in LPS-Induced Endotoxemia, J. Endotoxin Res, doi:10.1177/0968051907078605
Chen, Lee, Chuang, Li, Ning et al., Curcumin Inhibits HCV Replication by Induction of Heme Oxygenase-1 and Suppression of AKT, Int. J. Mol. Med, doi:10.3892/ijmm.2012.1096
Chen, Liu, Guo, Emerging Coronaviruses: Genome Structure, Replication, and Pathogenesis, J. Med. Virol, doi:10.1002/jmv.25681
Chen, Moriyama, Chang, Ichinohe, Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome, Front. Microbiol, doi:10.3389/fmicb.2019.00050
Chen, Shien, Tiley, Chiou, Wang et al., Curcumin Inhibits Influenza Virus Infection and Haemagglutination Activity, Food Chem, doi:10.1016/j.foodchem.2009.09.011
Cheng, Yang, Hu, Zhu, Liu, Curcumin Attenuates Pulmonary Inflammation in Lipopolysaccharide Induced Acute Lung Injury in Neonatal Rat Model by Activating Peroxisome Proliferator-Activated Receptor γ (PPARγ) Pathway, Med. Sci. Monit, doi:10.12659/MSM.908714
Chung, Karnik, Saef, Bergmann, Barnard et al., SARS-CoV-2 and ACE2: The Biology and Clinical Data Settling the ARB and ACEI Controversy, EBioMedicine, doi:10.1016/j.ebiom.2020.102907
Crowley, Rudemiller, Immunologic Effects of the Renin-Angiotensin System, Jasn, doi:10.1681/ASN.2016101066
Czaikoski, Mota, Nascimento, Sônego, Castanheira et al., Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis, PLoS One, doi:10.1371/journal.pone.0148142
D'alessandro, Posma, Spronk, Cate, Tissue Factor (:Factor VIIa) in the Heart and Vasculature: More Than an Envelope, Thromb. Res, doi:10.1016/j.thromres.2018.06.020
D'ardes, Boccatonda, Rossi, Guagnano, Santilli et al., COVID-19 and RAS: Unravelling an Unclear Relationship, Int. J. Mol. Sci, doi:10.3390/ijms21083003
Dediego, Nieto-Torres, Regla-Nava, Jimenez-Guardeno, Fernandez-Delgado et al., Inhibition of NF-B-Mediated Inflammation in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice Increases Survival, J. Virol, doi:10.1128/jvi.02576-13
Deng, Hu, Zhang, Wang, Zhou et al., Suspected Myocardial Injury in Patients with COVID-19: Evidence from Front-Line Clinical Observation in Wuhan, China, Int. J. Cardiol, doi:10.1016/j.ijcard.2020.03.087
Dhillon, Aggarwal, Newman, Wolff, Kunnumakkara et al., Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer, Clin. Cancer Res, doi:10.1158/1078-0432.CCR-08-0024
Dushianthan, Grocott, Postle, Cusack, Acute Respiratory Distress Syndrome and Acute Lung Injury, Postgrad. Med. J, doi:10.1136/pgmj.2011.118398
Dutta, Ghosh, Basu, Curcumin Protects Neuronal Cells from Japanese Encephalitis Virus-Mediated Cell Death and Also Inhibits Infective Viral Particle Formation by Dysregulation of Ubiquitin-Proteasome System, J. Neuroimmune Pharmacol, doi:10.1007/s11481-009-9158-2
Eguchi, Kawai, Scalia, Rizzo, Understanding Angiotensin II Type 1 Receptor Signaling in Vascular Pathophysiology, Hypertension, doi:10.1161/HYPERTENSIONAHA.118.10266
Elfiky, Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp): A Molecular Docking Study, Life Sci, doi:10.1016/j.lfs.2020.117592
Falati, Edmead, Poole, Glycoprotein Ib-V-IX, a Receptor for von Willebrand Factor, Couples Physically and Functionally to the Fc Receptor γ-Chain, Fyn, and Lyn to Activate Human Platelets, Blood, doi:10.1182/blood.v94.5.1648
Fan, Beitler, Brochard, Calfee, Ferguson et al., COVID-19-associated Acute Respiratory Distress Syndrome: Is a Different Approach to Management Warranted?, Lancet Respir. Med, doi:10.1016/S2213-2600(20)30304-0
Gheblawi, Wang, Viveiros, Nguyen, Zhong et al., Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System, Circ. Res, doi:10.1161/CIRCRESAHA.120.317015
Grobler, Maphumulo, Grobbelaar, Bredenkamp, Laubscher et al., Covid-19: The rollercoaster of fibrin(ogen), d-dimer, von willebrand factor, p-selectin and their interactions with endothelial cells, platelets and erythrocytes, Int J Mol Sci, doi:10.3390/ijms21145168
Guan, -J, Ni, Hu, Liang et al., Clinical Characteristics of Coronavirus Disease 2019 in China, N. Engl. J. Med, doi:10.1056/NEJMoa2002032
Guo, Fan, Chen, Wu, Zhang et al., Cardiovascular Implications of Fatal Outcomes of Patients with Coronavirus Disease 2019 (COVID-19), JAMA Cardiol, doi:10.1001/jamacardio.2020.1017
Gupta, Garg, Roy, Comparative Docking and CoMFA Analysis of Curcumine Derivatives as HIV-1 Integrase Inhibitors, Mol. Divers, doi:10.1007/s11030-011-9304-7
Gupta, Patchva, Aggarwal, Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials, AAPS J, doi:10.1208/s12248-012-9432-8
Gómez-Moreno, Adrover, Hidalgo, Neutrophils as Effectors of Vascular Inflammation, Eur. J. Clin. Invest, doi:10.1111/eci.12940
Halpin, Mcivor, Whyatt, Adams, Harvey et al., Postdischarge Symptoms and Rehabilitation Needs in Survivors of COVID-19 Infection: A Cross-sectional Evaluation, J. Med. Virol, doi:10.1002/jmv.26368
Hassaniazad, Inchehsablagh, Kamali, Tousi, Eftekhar et al., The Clinical Effect of Nano Micelles Containing Curcumin as a Therapeutic Supplement in Patients with COVID-19 and the Immune Responses Balance Changes Following Treatment: A Structured Summary of a Study Protocol for a Randomised Controlled Trial, Trials, doi:10.1186/s13063-020-04824-y
Hergenhahn, Soto, Weninger, Polack, Hsu et al., The Chemopreventive Compound Curcumin Is an Efficient Inhibitor of Epstein-Barr Virus BZLF1 Transcription in Raji DR-LUC Cells, Mol. Carcinog, doi:10.1002/mc.10029
Hoffmann, Kleine-Weber, Schroeder, Krüger, Herrler et al., SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor, Cell, doi:10.1016/j.cell.2020.02.052
Huang, Huang, Wang, Li, Ren et al., 6-month Consequences of COVID-19 in Patients Discharged from Hospital: a Cohort Study, The Lancet, doi:10.1016/S0140-6736(20)32656-8
Huang, Wang, Li, Ren, Zhao et al., Clinical Features of Patients Infected with 2019 Novel Coronavirus in Wuhan, China, The Lancet, doi:10.1016/S0140-6736(20)30183-5
Huang, Yang, Xu, Xu, Liu, Structural and Functional Properties of SARS-CoV-2 Spike Protein: Potential Antivirus Drug Development for COVID-19, Acta Pharmacol. Sin, doi:10.1038/s41401-020-0485-4
Huynh, Wang, Luan, Silico Exploration of the Molecular Mechanism of Clinically Oriented Drugs for Possibly Inhibiting SARS-CoV-2's Main Protease, J. Phys. Chem. Lett, doi:10.1021/acs.jpclett.0c00994
Iba, Connors, Levy, The Coagulopathy, Endotheliopathy, and Vasculitis of COVID-19, Inflamm. Res, doi:10.1007/s00011-020-01401-6
Imai, Kuba, Rao, Huan, Guo et al., Angiotensinconverting Enzyme 2 Protects from Severe Acute Lung Failure, Nature, doi:10.1038/nature03712
Ip, Hoshi, Shouval, Snapper, Medzhitov, Antiinflammatory Effect of IL-10 Mediated by Metabolic Reprogramming of Macrophages, Science, doi:10.1126/science.aal3535
Jeong, Vaidya, Cho, Park, Kaewintajuk et al., Identification of Regulators of the Early Stage of Viral Hemorrhagic Septicemia Virus Infection during Curcumin Treatment, Fish Shellfish Immunol, doi:10.1016/j.fsi.2015.03.042
Jia, Cao, An, Zhang, Wang, Rapamycin Ameliorates Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting IL-1β and IL-18 Production, Int. Immunopharmacology, doi:10.1016/j.intimp.2018.12.017
Jiménez-Alcázar, Rangaswamy, Panda, Bitterling, Simsek et al., Host DNases Prevent Vascular Occlusion by Neutrophil Extracellular Traps, Science, doi:10.1126/science.aam8897
Johnson, Gulhati, Arrieta, Wang, Uchida et al., Curcumin Inhibits Proliferation of Colorectal Carcinoma by Modulating Akt/ mTOR Signaling, Anticancer Res
Kanai, Yoshimura, Asada, Imaizumi, Suzuki et al., A Phase I/II Study of Gemcitabine-Based Chemotherapy Plus Curcumin for Patients with Gemcitabine-Resistant Pancreatic Cancer, Cancer Chemother. Pharmacol, doi:10.1007/s00280-010-1470-2
Kanzawa, Nishigaki, Hayashi, Ishii, Furukawa et al., Augmentation of Chemokine Production by Severe Acute Respiratory Syndrome Coronavirus 3a/X1 and 7a/X4 Proteins through NF-Κb Activation, FEBS Lett, doi:10.1016/j.febslet.2006.11.046
Karunaweera, Raju, Gyengesi, Münch, Plant Polyphenols as Inhibitors of NF-Îob Induced Cytokine Productionâ€"a Potential Antiinflammatory Treatment for Alzheimer's Disease? Front, Mol. Neurosci, doi:10.3389/fnmol.2015.00024
Khan, Chen, Geiger, Role of Endolysosomes in Severe Acute Respiratory Syndrome Coronavirus-2 Infection and Coronavirus Disease 2019 Pathogenesis: Implications for Potential Treatments, Front. Pharmacol, doi:10.3389/fphar.2020.595888
Kuba, Imai, Rao, Gao, Guo et al., A Crucial Role of Angiotensin Converting Enzyme 2 (ACE2) in SARS Coronavirus-Induced Lung Injury, Nat. Med, doi:10.1038/nm1267
Lang, Wang, Moura, Siddiqi, Morrow et al., A Current Review of COVID-19 for the Cardiovascular Specialist, Am. Heart J, doi:10.1016/j.ahj.2020.04.025
Lefrançais, Mallavia, Zhuo, Calfee, Looney, Maladaptive Role of Neutrophil Extracellular Traps in Pathogen-Induced Lung Injury, JCI Insight, doi:10.1172/jci.insight.98178
Liao, Liu, Yuan, Wen, Xu et al., Single-cell Landscape of Bronchoalveolar Immune Cells in Patients with COVID-19, Nat. Med, doi:10.1038/s41591-020-0901-9
Liao, Ye, Timani, Zeng, She et al., Activation of NF-kappaB by the Full-Length Nucleocapsid Protein of the SARS Coronavirus, Acta Biochim. Biophys. Sinica, doi:10.1111/j.1745-7270.2005.00082.x
Lin, Ho, Chuo, Li, Wang et al., Effective Inhibition of MERS-CoV Infection by Resveratrol, BMC Infect. Dis, doi:10.1186/s12879-017-2253-8
Lin, Wu, Wang, Xiao, Xu, Regulatory T Cells and Acute Lung Injury: Cytokines, Uncontrolled Inflammation, and Therapeutic Implications, Front. Immunol, doi:10.3389/fimmu.2018.01545
Liu, Yang, Liu, Sui, Li, Efficacy and Therapeutic Potential of Curcumin against Sepsis-Induced Chronic Lung Injury in Male Albino Rats, J. Nutr. Health Aging, doi:10.1007/s12603-016-0722-1
Lu, Zhao, Li, Niu, Yang et al., Genomic Characterisation and Epidemiology of 2019 Novel Coronavirus: Implications for Virus Origins and Receptor Binding, The Lancet, doi:10.1016/S0140-6736(20)30251-8
Lv, An, Chen, Wang, Liu, Mechanism of Curcumin Resistance to Human Cytomegalovirus in HELF Cells, BMC Complement. Altern. Med, doi:10.1186/1472-6882-14-284
Lv, Lei, Wang, An, Li et al., Protective Effect of Curcumin against Cytomegalovirus Infection in Balb/c Mice, Environ. Toxicol. Pharmacol, doi:10.1016/j.etap.2014.04.017
Ma, Guo, Zhao, Wu, Sun, The Effect of Curcumin on NF-Κb Expression in Rat with Lumbar Intervertebral Disc Degeneration, Eur. Rev. Med. Pharmacol. Sci
Mahmudpour, Roozbeh, Keshavarz, Farrokhi, Nabipour, COVID-19 Cytokine Storm: The Anger of Inflammation, Cytokine, doi:10.1016/j.cyto.2020.155151
Manoharan, Haridas, Vasanthakumar, Muthu, Thavoorullah et al., Curcumin: a Wonder Drug as a Preventive Measure for COVID19 Management, Ind. J. Clin. Biochem, doi:10.1007/s12291-020-00902-9
Mason, Pathogenesis of COVID-19 from a Cell Biology Perspective, Eur. Respir. J, doi:10.1183/13993003.00607-2020
Maurya, Kumar, Prasad, Bhatt, Saxena, Structure-based Drug Designing for Potential Antiviral Activity of Selected Natural Products from Ayurveda against SARS-CoV-2 Spike Glycoprotein and its Cellular Receptor, VirusDis, doi:10.1007/s13337-020-00598-8
Mayanglambam, Dangelmaier, Thomas, Damodar Reddy, Daniel et al., Curcumin Inhibits GPVI-Mediated Platelet Activation by Interfering with the Kinase Activity of Syk and the Subsequent Activation of PLCγ2, Platelets, doi:10.3109/09537100903528269
Mcfadyen, Stevens, Peter, The Emerging Threat of (Micro) Thrombosis in COVID-19 and its Therapeutic Implications, Circ. Res, doi:10.1161/CIRCRESAHA.120.317447
Middleton, He, Denorme, Campbell, Ng et al., Neutrophil Extracellular Traps Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome, Blood, doi:10.1182/blood.2020007008
Motohashi, Vanam, Gollapudi, Silico Study of Curcumin and Folic Acid as Potent Inhibitors of Human Transmembrane Protease Serine 2 in the Treatment of COVID-19, INNOSC Theranostics Pharmacol. Sci, doi:10.36922/itps.v3i2.935
Mounce, Cesaro, Carrau, Vallet, Vignuzzi, Curcumin Inhibits Zika and Chikungunya Virus Infection by Inhibiting Cell Binding, Antiviral Res, doi:10.1016/j.antiviral.2017.03.014
Murakami, Kamimura, Hirano, Pleiotropy and Specificity: Insights from the Interleukin 6 Family of Cytokines, Immunity, doi:10.1016/j.immuni.2019.03.027
Nemmar, Subramaniyan, Ali, Protective Effect of Curcumin on Pulmonary and Cardiovascular Effects Induced by Repeated Exposure to Diesel Exhaust Particles in Mice, PLoS One, doi:10.1371/journal.pone.0039554
Nieto-Torres, Verdiá-Báguena, Jimenez-Guardeño, Regla-Nava, Castaño-Rodriguez et al., Severe Acute Respiratory Syndrome Coronavirus E Protein Transports Calcium Ions and Activates the NLRP3 Inflammasome, Virology, doi:10.1016/j.virol.2015.08.010
Nishimura, Tsuji, Masuda, Nakagawa, Nakahara et al., Angiotensin II Increases Plasminogen Activator Inhibitor-1 and Tissue Factor mRNA Expression without Changing that of Tissue Type Plasminogen Activator or Tissue Factor Pathway Inhibitor in Cultured Rat Aortic Endothelial Cells, Thromb. Haemost, doi:10.1055/s-0038-1656136
Obata, Kojima, Masaki, Okabayashi, Yokota et al., Curcumin Prevents Replication of Respiratory Syncytial Virus and the Epithelial Responses to it in Human Nasal Epithelial Cells, PLoS One, doi:10.1371/journal.pone.0070225
Ou, Mizushina, Wang, Chuang, Nadar et al., Structure-activity Relationship Analysis of Curcumin Analogues on Anti-influenza Virus Activity, FEBS J, doi:10.1111/febs.12503
Paciello, Fetoni, Mezzogori, Rolesi, Di Pino et al., The Dual Role of Curcumin and Ferulic Acid in Counteracting Chemoresistance and Cisplatin-Induced Ototoxicity, Sci. Rep, doi:10.1038/s41598-020-57965-0
Paliogiannis, Mangoni, Dettori, Nasrallah, Pintus et al., D-dimer Concentrations and COVID-19 Severity: A Systematic Review and Meta-Analysis, Front. Public Health, doi:10.3389/fpubh.2020.00432
Papayannopoulos, Neutrophil Extracellular Traps in Immunity and Disease, Nat. Rev. Immunol, doi:10.1038/nri.2017.105
Park, Jeong, Hoon, Kim, Kim et al., Diarylheptanoids from Alnus Japonica Inhibit Papain-like Protease of Severe Acute Respiratory Syndrome Coronavirus, Biol. Pharm. Bull, doi:10.1248/bpb.b12-00623
Park, Kim, Kim, Jeong, Kim et al., Tanshinones as Selective and Slow-Binding Inhibitors for SARS-CoV Cysteine Proteases, Bioorg. Med. Chem, doi:10.1016/j.bmc.2012.07.038
Patell, Bogue, Koshy, Bindal, Merrill et al., Postdischarge Thrombosis and Hemorrhage in Patients with COVID-19, Blood, doi:10.1182/blood.2020007938
Pendurthi, Williams, Rao, Inhibition of Tissue Factor Gene Activation in Cultured Endothelial Cells by Curcumin, Arterioscler Thromb Vasc Biol, doi:10.1161/01.ATV.17.12.3406
Prasad, Stone, Holmes, Gersh, Reperfusion Injury, Microvascular Dysfunction, and Cardioprotection, Circulation, doi:10.1161/CIRCULATIONAHA.108.814640
Rahardjo, Widjajanto, Sujuti, Keman, Curcumin Decreased Level of Proinflammatory Cytokines in Monocyte Cultures Exposed to Preeclamptic Plasma by Affecting the Transcription Factors NF-Κb and PPAR-γ, Biomarkers Genomic Med, doi:10.1016/j.bgm.2014.06.002
Ramirez Boscá, Soler, Carrión-Gutiérrez, Pamies Mira, Pardo Zapata et al., An Hydroalcoholic Extract of Curcuma Longa Lowers the Abnormally High Values of Human-Plasma Fibrinogen, Mech. Ageing Dev, doi:10.1016/S0047-6374(00)00089-0
Rapkiewicz, Mai, Carsons, Pittaluga, Kleiner et al., Megakaryocytes and Platelet-Fibrin Thrombi Characterize Multi-Organ Thrombosis at Autopsy in COVID-19: A Case Series, EClinicalMedicine, doi:10.1016/j.eclinm.2020.100434
Riphagen, Gomez, Gonzalez-Martinez, Wilkinson, Theocharis, Hyperinflammatory Shock in Children during COVID-19 Pandemic, The Lancet, doi:10.1016/S0140-6736(20)31094-1
Rodrigues, De Sá, Ishimoto, Becerra, Oliveira et al., Inflammasomes Are Activated in Response to SARS-CoV-2 Infection and Are Associated with COVID-19 Severity in Patients, J. Exp. Med, doi:10.1084/jem.20201707
Roy, Sarkar, Celik, Ghosh, Basu et al., Can Concomitant Use of Zinc and Curcumin with Other Immunity-boosting Nutraceuticals Be the Arsenal against COVID -19?, Phytotherapy Res, doi:10.1002/ptr.6766
Ruiz-Ortega, Lorenzo, Suzuki, Rupérez, Egido, Proinflammatory Actions of Angiotensins, Curr. Opin. Nephrol. Hypertens, doi:10.1097/00041552-200105000-00005
Rut, Groborz, Zhang, Sun, Zmudzinski et al., SARS-CoV-2 Mpro Inhibitors and Activity-Based Probes for Patient-Sample Imaging, Nat. Chem. Biol, doi:10.1038/s41589-020-00689-z
Saeedi-Boroujeni, Mahmoudian-Sani, Bahadoram, Alghasi, COVID-19: A Case for Inhibiting NLRP3 Inflammasome, Suppression of Inflammation with Curcumin?, Basic Clin. Pharmacol. Toxicol, doi:10.1111/bcpt.13503
Saffarzadeh, Juenemann, Queisser, Lochnit, Barreto et al., Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones, PLoS One, doi:10.1371/journal.pone.0032366
Sang, Miller, Blecha, Macrophage Polarization in Virus-Host Interactions, J. Clin. Cel. Immunol, doi:10.4172/2155-9899.1000311
Sathler, Hemostatic Abnormalities in Covid-19: A Guided Review, Acad. Bras. Ciênc, doi:10.1590/0001-3765202020200834
Saxton, Sabatini, mTOR Signaling in Growth, Metabolism, and Disease, Cell, doi:10.1016/j.cell.2017.02.004
Schneider, Failing the Test -the Tragic Data Gap Undermining the U.S. Pandemic Response, N. Engl. J. Med, doi:10.1056/nejmp2014836
Schönrich, Raftery, Neutrophil Extracellular Traps Go Viral, Front. Immunol, doi:10.3389/fimmu.2016.00366
Shah, Nawaz, Pertani, Roomi, Mahmood et al., Inhibitory Effect of Curcumin, a Food Spice from Turmeric, on Platelet-Activating Factor-and Arachidonic Acid-Mediated Platelet Aggregation through Inhibition of Thromboxane Formation and Ca2+ Signaling, Biochem. Pharmacol, doi:10.1016/S0006-2952(99)00206-3
Shi, Nabar, Huang, Kehrl, SARS-coronavirus Open Reading Frame-8b Triggers Intracellular Stress Pathways and Activates NLRP3 Inflammasomes, Cell Death Discov, doi:10.1038/s41420-019-0181-7
Silva, Catalão, Felippotti, Oliveira-Pelegrin, Petenusci et al., Curcumin Suppresses Inflammatory Cytokines and Heat Shock Protein 70 Release and Improves Metabolic Parameters during Experimental Sepsis, Pharm. Biol, doi:10.1080/13880209.2016.1260598
Silva, Negrini, Macêdo Rocco, Mechanisms of Ventilator-Induced Lung Injury in Healthy Lungs, Best Pract. Res. Clin. Anaesthesiology, doi:10.1016/j.bpa.2015.08.004
Simonnet, Chetboun, Poissy, Raverdy, Noulette et al., High Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Requiring Invasive Mechanical Ventilation, Obesity, doi:10.1002/oby.22831
Siu, Yuen, Castano-Rodriguez, Ye, Yeung et al., Severe Acute Respiratory Syndrome Coronavirus ORF3a Protein Activates the NLRP3 Inflammasome by Promoting TRAF3-dependent Ubiquitination of ASC, FASEB j, doi:10.1096/fj.201802418R
Skurk, Van Harmelen, Hauner, Angiotensin II Stimulates the Release of Interleukin-6 and Interleukin-8 from Cultured Human Adipocytes by Activation of NF-Κb, Arterioscler Thromb Vasc Biol, doi:10.1161/01.ATV.0000131266.38312.2e
Solt, May, The IκB Kinase Complex: Master Regulator of NF-Κb Signaling, Immunol. Res, doi:10.1007/s12026-008-8025-1
Soni, Mehta, Ratre, Tiwari, Amit et al., Curcumin, a Traditional Spice Component, Can Hold the Promise against COVID-19?, Eur. J. Pharmacol, doi:10.1016/j.ejphar.2020.173551
Srivastava, Bordia, Verma, Curcumin, a Major Component of Food Spice Turmeric (Curcuma longa) Inhibits Aggregation and Alters Eicosanoid Metabolism in Human Blood Platelets, Prostaglandins, Leukot. Essent. Fatty Acids, doi:10.1016/0952-3278(95)90040-3
Stefanini, Montorfano, Trabattoni, Andreini, Ferrante et al., ST-Elevation Myocardial Infarction in Patients With COVID-19, Circulation, doi:10.1161/CIRCULATIONAHA.120.047525
Tahmasebi, El-Esawi, Mahmoud, Timoshin, Valizadeh et al., Immunomodulatory Effects of Nanocurcumin on Th17 Cell Responses in Mild and Severe COVID-19 Patients, J. Cel. Physiol, doi:10.1002/jcp.30233
Tang, Li, Wang, Sun, Abnormal Coagulation Parameters Are Associated with Poor Prognosis in Patients with Novel Coronavirus Pneumonia, J. Thromb. Haemost, doi:10.1111/jth.14768
Temiz-Resitoglu, Kucukkavruk, Guden, Cecen, Sari et al., Activation of mTOR/IκB-A/nf-Κb Pathway Contributes to LPS-Induced Hypotension and Inflammation in Rats, Eur. J. Pharmacol, doi:10.1016/j.ejphar.2017.02.034
Thangapazham, Shaheduzzaman, Kim, Passi, Tadese et al., Androgen Responsive and Refractory Prostate Cancer Cells Exhibit Distinct Curcumin Regulated Transcriptome, Cancer Biol. Ther, doi:10.4161/cbt.7.9.6469
Thimmulappa, Mudnakudu-Nagaraju, Shivamallu, Subramaniam, Radhakrishnan et al., Antiviral and Immunomodulatory Activity of Curcumin: A Case for Prophylactic Therapy for COVID-19, Heliyon, doi:10.1016/j.heliyon.2021.e06350
Valizadeh, Abdolmohammadi-Vahid, Danshina, Ziya Gencer, Ammari et al., Nano-curcumin Therapy, a Promising Method in Modulating Inflammatory Cytokines in COVID-19 Patients, Int. Immunopharmacology, doi:10.1016/j.intimp.2020.107088
Vallejo, Teis, Mateu, Bayés-Genís, Persistent Chest Pain after Recovery of COVID-19: Microvascular Disease-Related Angina?, Eur. Hear. J. -Case Rep, doi:10.1093/ehjcr/ytab105
Vinten-Johansen, Zhao, Zatta, Kin, Halkos et al., Postconditioning A New Link in Nature's Armor against Myocardial Ischemia-Reperfusion Injury, Basic Res. Cardiol, doi:10.1007/s00395-005-0523-x
Vishvakarma, Kumar, Singh, Role of Curcumindependent Modulation of Tumor Microenvironment of a Murine T Cell Lymphoma in Altered Regulation of Tumor Cell Survival, Toxicol. Appl. Pharmacol, doi:10.1016/j.taap.2011.03.002
Wang, An, Wang, Bao, Li et al., Curcumin Ameliorated Ventilator-Induced Lung Injury in Rats, Biomed. Pharmacother, doi:10.1016/j.biopha.2017.12.100
Wang, Tang, Duan, Yang, Curcumin as a Therapeutic Agent for Blocking NF-Κb Activation in Ulcerative Colitis, Immunopharmacology and Immunotoxicology, doi:10.1080/08923973.2018.1469145
Wang, Wang, Tootle, Philip, Zhao, Curcumin Promotes Cardiac Repair and Ameliorates Cardiac Dysfunction Following Myocardial Infarction, Br. J. Pharmacol, doi:10.1111/j.1476-5381.2012.02109.x
Wen, Kuo, Jan, Liang, Wang et al., Specific Plant Terpenoids and Lignoids Possess Potent Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus, J. Med. Chem, doi:10.1021/jm070295s
Wrapp, Wang, Corbett, Goldsmith, Hsieh et al., Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation, Science, doi:10.1126/science.aax090210.1126/science.abb2507
Wu, Jan, Ma, Kuo, Juan et al., Small Molecules Targeting Severe Acute Respiratory Syndrome Human Coronavirus, doi:10.1073/pnas.0403596101
Wu, Mcgoogan, Characteristics of and Important Lessons from the Coronavirus Disease 2019 (COVID-19) Outbreak in China, Jama, doi:10.1001/jama.2020.2648
Xia, Liu, Wang, Xu, Lan et al., Inhibition of SARS-CoV-2 (Previously 2019-nCoV) Infection by a Highly Potent Pan-Coronavirus Fusion Inhibitor Targeting its Spike Protein that Harbors a High Capacity to Mediate Membrane Fusion, Cell Res, doi:10.1038/s41422-020-0305-x
Xia, Zhu, Liu, Lan, Xu et al., Fusion Mechanism of 2019-nCoV and Fusion Inhibitors Targeting HR1 Domain in Spike Protein, Cell Mol Immunol, doi:10.1038/s41423-020-0374-2
Xiao, Yang, Sun, Sun, Curcumin Protects against Sepsis-Induced Acute Lung Injury in Rats, J. Surg. Res, doi:10.1016/j.jss.2011.11.1032
Xu, Lin, Yang, Guo, Cao et al., The Effect of Curcumin on Sepsis-Induced Acute Lung Injury in a Rat Model through the Inhibition of the TGF-B1/smad3 Pathway, Int. Immunopharmaco, doi:10.1016/j.intimp.2013.03.014
Yadav, Jee, Awasthi, Curcumin Suppresses the Production of Pro-inflammatory Cytokine Interleukin-18 in Lipopolysaccharide Stimulated Murine Macrophage-like Cells, Ind. J. Clin. Biochem, doi:10.1007/s12291-014-0452-2
Yang, Lee, Si, Lee, You et al., Curcumin Shows Antiviral Properties against Norovirus, Molecules, doi:10.3390/molecules21101401
Yang, Li, Huang, Curcumin Modified Silver Nanoparticles for Highly Efficient Inhibition of Respiratory Syncytial Virus Infection, Nanoscale, doi:10.1039/c5nr07918g
Yang, Wu, Li, You, Protective Effect of Curcumin against Cardiac Dysfunction in Sepsis Rats, Pharm. Biol, doi:10.3109/13880209.2012.742116
Yeh, Wang, Curcumin Attenuates Hemorrhagic Shock and Blood Replenish Resuscitation-Induced Impairment of Pulmonary Barrier Function by Increasing SIRT1 and Reducing Malondialdehyde and TNF-α Contents and Neutrophil Infiltration in Lung in a Dose-dependent Fashion, Transplant. Proc, doi:10.1016/j.transproceed.2020.01.133
Yin, Guo, Li, Tang, Li et al., Curcumin Suppresses IL-1β Secretion and Prevents Inflammation through Inhibition of the NLRP3 Inflammasome, J.Immunol, doi:10.4049/jimmunol.1701495
Zahedipour, Hosseini, Sathyapalan, Majeed, Jamialahmadi et al., Potential Effects of Curcumin in the Treatment of COVID -19 Infection, Phytotherapy Res, doi:10.1002/ptr.6738
Zhang, -N, Yu, Zhang, Chen et al., Curcumin Down Regulates Homeobox Gene NKX3.1 in Prostate Cancer Cell LNCaP, Acta Pharmacologica Sinica, doi:10.1111/j.1745-7254.2007.00501.x
Zhang, Gu, Qin, Liang, Effect of Curcumin on the Adhesion of Platelets to Brain Microvascular Endothelial Cellsin Vitro1, Acta Pharmacol. Sin, doi:10.1111/j.1745-7254.2008.00813.x
Zhang, Lin, Sun, Curth, Drosten et al., Crystal Structure of SARS-CoV-2 Main Protease Provides a Basis for Design of Improved α-ketoamide Inhibitors, Science, doi:10.1126/science.abb3405
Zhang, Liu, Wang, Yang, Li et al., SARS-CoV-2 Binds Platelet ACE2 to Enhance Thrombosis in COVID-19, J. Hematol. Oncol, doi:10.1186/s13045-020-00954-7
Zhou, Yu, Du, Fan, Liu et al., Clinical Course and Risk Factors for Mortality of Adult Inpatients with COVID-19 in Wuhan, China: a Retrospective Cohort Study, The Lancet, doi:10.1016/S0140-6736(20)30566-3
Zhu, Ding, Zhang, Yuan, Wang et al., Curcumin Inhibits Bovine Herpesvirus Type 1 Entry into MDBK Cells, Acta Virol, doi:10.4149/av_2015_03_221
{ 'DOI': '10.3389/fphar.2021.675287', 'ISSN': ['1663-9812'], 'URL': 'http://dx.doi.org/10.3389/fphar.2021.675287', 'abstract': '<jats:p>Coronavirus disease 2019 (COVID-19) is an infectious disease that rapidly spread ' 'throughout the world leading to high mortality rates. Despite the knowledge of previous ' 'diseases caused by viruses of the same family, such as MERS and SARS-CoV, management and ' 'treatment of patients with COVID-19 is a challenge. One of the best strategies around the ' 'world to help combat the COVID-19 has been directed to drug repositioning; however, these ' 'drugs are not specific to this new virus. Additionally, the pathophysiology of COVID-19 is ' 'highly heterogeneous, and the way of SARS-CoV-2 modulates the different systems in the host ' 'remains unidentified, despite recent discoveries. This complex and multifactorial response ' 'requires a comprehensive therapeutic approach, enabling the integration and refinement of ' 'therapeutic responses of a given single compound that has several action potentials. In this ' 'context, natural compounds, such as Curcumin, have shown beneficial effects on the ' 'progression of inflammatory diseases due to its numerous action mechanisms: antiviral, ' 'anti-inflammatory, anticoagulant, antiplatelet, and cytoprotective. These and many other ' 'effects of curcumin make it a promising target in the adjuvant treatment of COVID-19. Hence, ' 'the purpose of this review is to specifically point out how curcumin could interfere at ' 'different times/points during the infection caused by SARS-CoV-2, providing a substantial ' 'contribution of curcumin as a new adjuvant therapy for the treatment of COVID-19.</jats:p>', 'alternative-id': ['10.3389/fphar.2021.675287'], 'author': [ {'affiliation': [], 'family': 'Rattis', 'given': 'Bruna A. C.', 'sequence': 'first'}, {'affiliation': [], 'family': 'Ramos', 'given': 'Simone G.', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Celes', 'given': 'Mara R. N.', 'sequence': 'additional'}], 'container-title': 'Frontiers in Pharmacology', 'container-title-short': 'Front. Pharmacol.', 'content-domain': {'crossmark-restriction': True, 'domain': ['frontiersin.org']}, 'created': {'date-parts': [[2021, 5, 7]], 'date-time': '2021-05-07T15:40:35Z', 'timestamp': 1620402035000}, 'deposited': { 'date-parts': [[2021, 5, 7]], 'date-time': '2021-05-07T15:40:42Z', 'timestamp': 1620402042000}, 'indexed': {'date-parts': [[2024, 5, 13]], 'date-time': '2024-05-13T11:18:02Z', 'timestamp': 1715599082284}, 'is-referenced-by-count': 79, 'issued': {'date-parts': [[2021, 5, 7]]}, 'license': [ { 'URL': 'https://creativecommons.org/licenses/by/4.0/', 'content-version': 'vor', 'delay-in-days': 0, 'start': { 'date-parts': [[2021, 5, 7]], 'date-time': '2021-05-07T00:00:00Z', 'timestamp': 1620345600000}}], 'link': [ { 'URL': 'https://www.frontiersin.org/articles/10.3389/fphar.2021.675287/full', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'member': '1965', 'original-title': [], 'prefix': '10.3389', 'published': {'date-parts': [[2021, 5, 7]]}, 'published-online': {'date-parts': [[2021, 5, 7]]}, 'publisher': 'Frontiers Media SA', 'reference': [ { 'DOI': '10.1097/CEJ.0b013e32834ef194', 'article-title': 'Curcumin', 'author': 'Alexandrow', 'doi-asserted-by': 'publisher', 'first-page': '407', 'journal-title': 'Eur. J. Cancer Prev.', 'key': 'B1', 'volume': '21', 'year': '2012'}, { 'DOI': '10.1038/srep27539', 'article-title': 'Curcumin Inhibits HIV-1 by Promoting Tat Protein Degradation', 'author': 'Ali', 'doi-asserted-by': 'publisher', 'first-page': '1', 'journal-title': 'Sci. Rep.', 'key': 'B2', 'volume': '6', 'year': '2016'}, { 'DOI': '10.3390/molecules25030724', 'article-title': 'Curcumin, an Active Constituent of Turmeric Spice: Implication in the ' 'Prevention of Lung Injury Induced by Benzo(a) Pyrene (BAP) in Rats', 'author': 'Almatroodi', 'doi-asserted-by': 'publisher', 'first-page': '724', 'journal-title': 'Molecules', 'key': 'B3', 'volume': '25', 'year': '2020'}, { 'DOI': '10.1016/j.hjc.2020.05.007', 'article-title': 'Outbreak of SARS-CoV2: Pathogenesis of Infection and Cardiovascular ' 'Involvement', 'author': 'Amirfakhryan', 'doi-asserted-by': 'publisher', 'first-page': '13', 'journal-title': 'Hellenic J. Cardiol.', 'key': 'B4', 'volume': '62', 'year': '2021'}, { 'DOI': '10.1126/science.1085658', 'article-title': 'Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of ' 'Anti-SARS Drugs', 'author': 'Anand', 'doi-asserted-by': 'publisher', 'first-page': '1763', 'journal-title': 'Science', 'key': 'B5', 'volume': '300', 'year': '2003'}, { 'DOI': '10.1136/gutjnl-2012-304299', 'article-title': 'Turmeric Curcumin Inhibits Entry of All Hepatitis C Virus Genotypes ' 'into Human Liver Cells', 'author': 'Anggakusuma', 'doi-asserted-by': 'publisher', 'first-page': '1137', 'journal-title': 'Gut', 'key': 'B6', 'volume': '63', 'year': '2014'}, { 'DOI': '10.1016/j.intimp.2013.09.024', 'article-title': 'Curcumin Inhibits Agent-Induced Human Neutrophil Functions In Vitro and ' 'Lipopolysaccharide-Induced Neutrophilic Infiltration In Vivo', 'author': 'Antoine', 'doi-asserted-by': 'publisher', 'first-page': '1101', 'journal-title': 'Int. Immunopharmacology', 'key': 'B7', 'volume': '17', 'year': '2013'}, { 'DOI': '10.3109/13880209.2013.766895', 'article-title': 'Modulation of Cyclophosphamide-Induced Early Lung Injury by Allicin', 'author': 'Ashry', 'doi-asserted-by': 'publisher', 'first-page': '806', 'journal-title': 'Pharm. Biol.', 'key': 'B8', 'volume': '51', 'year': '2013'}, { 'DOI': '10.3390/cells9091962', 'article-title': 'Targeting the sAC-dependent cAMP Pool to Prevent SARS-Cov-2 Infection', 'author': 'Aslam', 'doi-asserted-by': 'publisher', 'first-page': '1962', 'journal-title': 'Cells', 'key': 'B9', 'volume': '9', 'year': '2020'}, { 'DOI': '10.1002/fsn3.1858', 'article-title': 'Curcumin (A Constituent of Turmeric): New Treatment Option against ' 'COVID‐19', 'author': 'Babaei', 'doi-asserted-by': 'publisher', 'first-page': '5215', 'journal-title': 'Food Sci. Nutr.', 'key': 'B10', 'volume': '8', 'year': '2020'}, { 'DOI': '10.1016/j.antiviral.2018.12.002', 'article-title': 'Inhibition of Dengue Virus by Curcuminoids', 'author': 'Balasubramanian', 'doi-asserted-by': 'publisher', 'first-page': '71', 'journal-title': 'Antiviral Res.', 'key': 'B11', 'volume': '162', 'year': '2019'}, { 'DOI': '10.1016/j.csbj.2020.03.025', 'article-title': 'Predicting Commercially Available Antiviral Drugs that May Act on the ' 'Novel Coronavirus (SARS-CoV-2) through a Drug-Target Interaction Deep ' 'Learning Model', 'author': 'Beck', 'doi-asserted-by': 'publisher', 'first-page': '784', 'journal-title': 'Comput. Struct. Biotechnol. J.', 'key': 'B12', 'volume': '18', 'year': '2020'}, { 'DOI': '10.1158/0008-5472.CAN-08-2367', 'article-title': 'Curcumin Disrupts the Mammalian Target of Rapamycin-Raptor Complex', 'author': 'Beevers', 'doi-asserted-by': 'publisher', 'first-page': '1000', 'journal-title': 'Cancer Res.', 'key': 'B14', 'volume': '69', 'year': '2009'}, { 'DOI': '10.1002/ijc.21932', 'article-title': 'Curcumin Inhibits the Mammalian Target of Rapamycin-Mediated Signaling ' 'Pathways in Cancer Cells', 'author': 'Beevers', 'doi-asserted-by': 'publisher', 'first-page': '757', 'journal-title': 'Int. J. Cancer', 'key': 'B13', 'volume': '119', 'year': '2006'}, { 'DOI': '10.1160/TH17-09-0630', 'article-title': 'The Pathophysiological Role of Neutrophil Extracellular Traps in ' 'Inflammatory Diseases', 'author': 'Bonaventura', 'doi-asserted-by': 'publisher', 'first-page': '006', 'journal-title': 'Thromb. Haemost.', 'key': 'B15', 'volume': '118', 'year': '2018'}, { 'DOI': '10.1016/S0049-3848(08)70018-5', 'article-title': 'Tissue Factor Activity and Function in Blood Coagulation', 'author': 'Butenas', 'doi-asserted-by': 'publisher', 'first-page': 'S42', 'journal-title': 'Thromb. Res.', 'key': 'B16', 'volume': '122', 'year': '2008'}, { 'DOI': '10.1016/j.cmi.2020.09.052', 'article-title': 'Follow-up of Adults with Noncritical COVID-19 Two Months after Symptom ' 'Onset', 'author': 'Carvalho-Schneider', 'doi-asserted-by': 'publisher', 'first-page': '258', 'journal-title': 'Clin. Microbiol. Infect.', 'key': 'B17', 'volume': '27', 'year': '2021'}, { 'DOI': '10.1016/j.biopha.2020.109946', 'article-title': 'Curcumin Regulates the Differentiation of Naïve CD4+T Cells and ' 'Activates IL-10 Immune Modulation against Acute Lung Injury in Mice', 'author': 'Chai', 'doi-asserted-by': 'publisher', 'first-page': '109946', 'journal-title': 'Biomed. Pharmacother.', 'key': 'B18', 'volume': '125', 'year': '2020'}, { 'DOI': '10.1080/22221751.2020.1719902', 'article-title': 'Genomic Characterization of the 2019 Novel Human-Pathogenic Coronavirus ' 'Isolated from a Patient with Atypical Pneumonia after Visiting Wuhan', 'author': 'Chan', 'doi-asserted-by': 'publisher', 'first-page': '221', 'journal-title': 'Emerging Microbes Infect.', 'key': 'B19', 'volume': '9', 'year': '2020'}, { 'DOI': '10.1007/s13721-019-0196-2', 'article-title': 'Comparative Binding Studies of Curcumin and Tangeretin on Up-Stream ' 'Elements of NF-kB Cascade: a Combined Molecular Docking Approach', 'author': 'Cheemanapalli', 'doi-asserted-by': 'publisher', 'first-page': '1', 'journal-title': 'Netw. Model. Anal. Health Inform. Bioinforma', 'key': 'B20', 'volume': '8', 'year': '2019'}, { 'DOI': '10.1016/j.foodchem.2009.09.011', 'article-title': 'Curcumin Inhibits Influenza Virus Infection and Haemagglutination ' 'Activity', 'author': 'Chen', 'doi-asserted-by': 'publisher', 'first-page': '1346', 'journal-title': 'Food Chem.', 'key': 'B22', 'volume': '119', 'year': '2010'}, { 'DOI': '10.1177/0968051907078605', 'article-title': 'Pretreatment of Curcumin Attenuates Coagulopathy and Renal Injury in ' 'LPS-Induced Endotoxemia', 'author': 'Chen', 'doi-asserted-by': 'publisher', 'first-page': '15', 'journal-title': 'J. Endotoxin Res.', 'key': 'B21', 'volume': '13', 'year': '2007'}, { 'DOI': '10.3389/fmicb.2019.00050', 'article-title': 'Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates ' 'the NLRP3 Inflammasome', 'author': 'Chen', 'doi-asserted-by': 'publisher', 'first-page': '1', 'journal-title': 'Front. Microbiol.', 'key': 'B24', 'volume': '10', 'year': '2019'}, { 'DOI': '10.3892/ijmm.2012.1096', 'article-title': 'Curcumin Inhibits HCV Replication by Induction of Heme Oxygenase-1 and ' 'Suppression of AKT', 'author': 'Chen', 'doi-asserted-by': 'publisher', 'first-page': '1021', 'journal-title': 'Int. J. Mol. Med.', 'key': 'B23', 'volume': '30', 'year': '2012'}, { 'DOI': '10.1002/jmv.25681', 'article-title': 'Emerging Coronaviruses: Genome Structure, Replication, and Pathogenesis', 'author': 'Chen', 'doi-asserted-by': 'publisher', 'first-page': '418', 'journal-title': 'J. Med. Virol.', 'key': 'B25', 'volume': '92', 'year': '2020'}, { 'DOI': '10.12659/MSM.908714', 'article-title': 'Curcumin Attenuates Pulmonary Inflammation in Lipopolysaccharide ' 'Induced Acute Lung Injury in Neonatal Rat Model by Activating ' 'Peroxisome Proliferator-Activated Receptor γ (PPARγ) Pathway', 'author': 'Cheng', 'doi-asserted-by': 'publisher', 'first-page': '1178', 'journal-title': 'Med. Sci. Monit.', 'key': 'B26', 'volume': '24', 'year': '2018'}, { 'DOI': '10.1016/j.ebiom.2020.102907', 'article-title': 'SARS-CoV-2 and ACE2: The Biology and Clinical Data Settling the ARB and ' 'ACEI Controversy', 'author': 'Chung', 'doi-asserted-by': 'publisher', 'first-page': '102907', 'journal-title': 'EBioMedicine', 'key': 'B27', 'volume': '58', 'year': '2020'}, { 'DOI': '10.1681/ASN.2016101066', 'article-title': 'Immunologic Effects of the Renin-Angiotensin System', 'author': 'Crowley', 'doi-asserted-by': 'publisher', 'first-page': '1350', 'journal-title': 'Jasn', 'key': 'B28', 'volume': '28', 'year': '2017'}, { 'DOI': '10.1371/journal.pone.0148142', 'article-title': 'Neutrophil Extracellular Traps Induce Organ Damage during Experimental ' 'and Clinical Sepsis', 'author': 'Czaikoski', 'doi-asserted-by': 'publisher', 'first-page': 'e0148142', 'journal-title': 'PLoS One', 'key': 'B29', 'volume': '11', 'year': '2016'}, { 'DOI': '10.1016/j.thromres.2018.06.020', 'article-title': 'Tissue Factor (:Factor VIIa) in the Heart and Vasculature: More Than an ' 'Envelope', 'author': 'D’Alessandro', 'doi-asserted-by': 'publisher', 'first-page': '130', 'journal-title': 'Thromb. Res.', 'key': 'B30', 'volume': '168', 'year': '2018'}, { 'DOI': '10.3390/ijms21083003', 'article-title': 'COVID-19 and RAS: Unravelling an Unclear Relationship', 'author': 'D’ardes', 'doi-asserted-by': 'publisher', 'first-page': '1', 'journal-title': 'Int. J. Mol. Sci.', 'key': 'B31', 'volume': '21', 'year': '2020'}, { 'DOI': '10.1128/jvi.02576-13', 'article-title': 'Inhibition of NF- B-Mediated Inflammation in Severe Acute Respiratory ' 'Syndrome Coronavirus-Infected Mice Increases Survival', 'author': 'DeDiego', 'doi-asserted-by': 'publisher', 'first-page': '913', 'journal-title': 'J. Virol.', 'key': 'B32', 'volume': '88', 'year': '2014'}, { 'DOI': '10.1016/j.ijcard.2020.03.087', 'article-title': 'Suspected Myocardial Injury in Patients with COVID-19: Evidence from ' 'Front-Line Clinical Observation in Wuhan, China', 'author': 'Deng', 'doi-asserted-by': 'publisher', 'first-page': '116', 'journal-title': 'Int. J. Cardiol.', 'key': 'B33', 'volume': '311', 'year': '2020'}, { 'DOI': '10.1158/1078-0432.CCR-08-0024', 'article-title': 'Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer', 'author': 'Dhillon', 'doi-asserted-by': 'publisher', 'first-page': '4491', 'journal-title': 'Clin. Cancer Res.', 'key': 'B34', 'volume': '14', 'year': '2008'}, { 'DOI': '10.1136/pgmj.2011.118398', 'article-title': 'Acute Respiratory Distress Syndrome and Acute Lung Injury', 'author': 'Dushianthan', 'doi-asserted-by': 'publisher', 'first-page': '612', 'journal-title': 'Postgrad. Med. J.', 'key': 'B35', 'volume': '87', 'year': '2011'}, { 'DOI': '10.1007/s11481-009-9158-2', 'article-title': 'Curcumin Protects Neuronal Cells from Japanese Encephalitis ' 'Virus-Mediated Cell Death and Also Inhibits Infective Viral Particle ' 'Formation by Dysregulation of Ubiquitin-Proteasome System', 'author': 'Dutta', 'doi-asserted-by': 'publisher', 'first-page': '328', 'journal-title': 'J. Neuroimmune Pharmacol.', 'key': 'B36', 'volume': '4', 'year': '2009'}, { 'DOI': '10.1161/HYPERTENSIONAHA.118.10266', 'article-title': 'Understanding Angiotensin II Type 1 Receptor Signaling in Vascular ' 'Pathophysiology', 'author': 'Eguchi', 'doi-asserted-by': 'publisher', 'first-page': '804', 'journal-title': 'Hypertension', 'key': 'B37', 'volume': '71', 'year': '2018'}, { 'DOI': '10.1016/j.lfs.2020.117592', 'article-title': 'Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against ' 'SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp): A Molecular Docking ' 'Study', 'author': 'Elfiky', 'doi-asserted-by': 'publisher', 'first-page': '117592', 'journal-title': 'Life Sci.', 'key': 'B38', 'volume': '253', 'year': '2020'}, { 'DOI': '10.1182/blood.v94.5.1648', 'article-title': 'Glycoprotein Ib-V-IX, a Receptor for von Willebrand Factor, Couples ' 'Physically and Functionally to the Fc Receptor γ-Chain, Fyn, and Lyn to ' 'Activate Human Platelets', 'author': 'Falati', 'doi-asserted-by': 'publisher', 'first-page': '1648', 'journal-title': 'Blood', 'key': 'B39', 'volume': '94', 'year': '1999'}, { 'DOI': '10.1016/S2213-2600(20)30304-0', 'article-title': 'COVID-19-associated Acute Respiratory Distress Syndrome: Is a Different ' 'Approach to Management Warranted?', 'author': 'Fan', 'doi-asserted-by': 'publisher', 'first-page': '816', 'journal-title': 'Lancet Respir. Med.', 'key': 'B40', 'volume': '8', 'year': '2020'}, { 'DOI': '10.1161/CIRCRESAHA.120.317015', 'article-title': 'Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of ' 'the Renin-Angiotensin System', 'author': 'Gheblawi', 'doi-asserted-by': 'publisher', 'first-page': '1456', 'journal-title': 'Circ. Res.', 'key': 'B41', 'volume': '126', 'year': '2020'}, { 'DOI': '10.1111/eci.12940', 'article-title': 'Neutrophils as Effectors of Vascular Inflammation', 'author': 'Gómez-Moreno', 'doi-asserted-by': 'publisher', 'first-page': 'e12940', 'journal-title': 'Eur. J. Clin. Invest.', 'key': 'B42', 'volume': '48', 'year': '2018'}, { 'DOI': '10.3390/ijms21145168', 'article-title': 'Covid-19: The rollercoaster of fibrin(ogen), d-dimer, von willebrand ' 'factor, p-selectin and their interactions with endothelial cells, ' 'platelets and erythrocytes', 'author': 'Grobler', 'doi-asserted-by': 'publisher', 'first-page': '5168', 'journal-title': 'Int J Mol Sci.', 'key': 'B43', 'volume': '21', 'year': '2020'}, { 'DOI': '10.1056/NEJMoa2002032', 'article-title': 'Clinical Characteristics of Coronavirus Disease 2019 in China', 'author': 'Guan', 'doi-asserted-by': 'publisher', 'first-page': '1708', 'journal-title': 'N. Engl. J. Med.', 'key': 'B44', 'volume': '382', 'year': '2020'}, { 'DOI': '10.1001/jamacardio.2020.1017', 'article-title': 'Cardiovascular Implications of Fatal Outcomes of Patients with ' 'Coronavirus Disease 2019 (COVID-19)', 'author': 'Guo', 'doi-asserted-by': 'publisher', 'first-page': '811', 'journal-title': 'JAMA Cardiol.', 'key': 'B45', 'volume': '5', 'year': '2020'}, { 'DOI': '10.1007/s11030-011-9304-7', 'article-title': 'Comparative Docking and CoMFA Analysis of Curcumine Derivatives as ' 'HIV-1 Integrase Inhibitors', 'author': 'Gupta', 'doi-asserted-by': 'publisher', 'first-page': '733', 'journal-title': 'Mol. Divers.', 'key': 'B46', 'volume': '15', 'year': '2011'}, { 'DOI': '10.1208/s12248-012-9432-8', 'article-title': 'Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials', 'author': 'Gupta', 'doi-asserted-by': 'publisher', 'first-page': '195', 'journal-title': 'AAPS J.', 'key': 'B47', 'volume': '15', 'year': '2013'}, { 'DOI': '10.1002/jmv.26368', 'article-title': 'Postdischarge Symptoms and Rehabilitation Needs in Survivors of ' 'COVID‐19 Infection: A Cross‐sectional Evaluation', 'author': 'Halpin', 'doi-asserted-by': 'publisher', 'first-page': '1013', 'journal-title': 'J. Med. Virol.', 'key': 'B48', 'volume': '93', 'year': '2021'}, { 'DOI': '10.1186/s13063-020-04824-y', 'article-title': 'The Clinical Effect of Nano Micelles Containing Curcumin as a ' 'Therapeutic Supplement in Patients with COVID-19 and the Immune ' 'Responses Balance Changes Following Treatment: A Structured Summary of ' 'a Study Protocol for a Randomised Controlled Trial', 'author': 'Hassaniazad', 'doi-asserted-by': 'publisher', 'first-page': '20', 'journal-title': 'Trials', 'key': 'B49', 'volume': '21', 'year': '2020'}, { 'DOI': '10.1002/mc.10029', 'article-title': 'The Chemopreventive Compound Curcumin Is an Efficient Inhibitor of ' 'Epstein-Barr Virus BZLF1 Transcription in Raji DR-LUC Cells*', 'author': 'Hergenhahn', 'doi-asserted-by': 'publisher', 'first-page': '137', 'journal-title': 'Mol. Carcinog.', 'key': 'B50', 'volume': '33', 'year': '2002'}, { 'DOI': '10.1016/j.cell.2020.02.052', 'article-title': 'SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a ' 'Clinically Proven Protease Inhibitor', 'author': 'Hoffmann', 'doi-asserted-by': 'publisher', 'first-page': '271', 'journal-title': 'Cell', 'key': 'B51', 'volume': '181', 'year': '2020'}, { 'DOI': '10.1016/S0140-6736(20)32656-8', 'article-title': '6-month Consequences of COVID-19 in Patients Discharged from Hospital: ' 'a Cohort Study', 'author': 'Huang', 'doi-asserted-by': 'publisher', 'first-page': '220', 'journal-title': 'The Lancet', 'key': 'B54', 'volume': '397', 'year': '2021'}, { 'DOI': '10.1016/S0140-6736(20)30183-5', 'article-title': 'Clinical Features of Patients Infected with 2019 Novel Coronavirus in ' 'Wuhan, China', 'author': 'Huang', 'doi-asserted-by': 'publisher', 'first-page': '497', 'journal-title': 'The Lancet', 'key': 'B52', 'volume': '395', 'year': '2020'}, { 'DOI': '10.1021/acs.jpclett.0c00994', 'article-title': 'In Silico Exploration of the Molecular Mechanism of Clinically Oriented ' "Drugs for Possibly Inhibiting SARS-CoV-2's Main Protease", 'author': 'Huynh', 'doi-asserted-by': 'publisher', 'first-page': '4413', 'journal-title': 'J. Phys. Chem. Lett.', 'key': 'B55', 'volume': '11', 'year': '2020'}, { 'DOI': '10.1007/s00011-020-01401-6', 'article-title': 'The Coagulopathy, Endotheliopathy, and Vasculitis of COVID-19', 'author': 'Iba', 'doi-asserted-by': 'publisher', 'first-page': '1181', 'journal-title': 'Inflamm. Res.', 'key': 'B56', 'volume': '69', 'year': '2020'}, { 'DOI': '10.1038/nature03712', 'article-title': 'Angiotensin-converting Enzyme 2 Protects from Severe Acute Lung Failure', 'author': 'Imai', 'doi-asserted-by': 'publisher', 'first-page': '112', 'journal-title': 'Nature', 'key': 'B57', 'volume': '436', 'year': '2005'}, { 'DOI': '10.1126/science.aal3535', 'article-title': 'Anti-inflammatory Effect of IL-10 Mediated by Metabolic Reprogramming ' 'of Macrophages', 'author': 'Ip', 'doi-asserted-by': 'publisher', 'first-page': '513', 'journal-title': 'Science', 'key': 'B58', 'volume': '356', 'year': '2017'}, { 'DOI': '10.1016/j.fsi.2015.03.042', 'article-title': 'Identification of Regulators of the Early Stage of Viral Hemorrhagic ' 'Septicemia Virus Infection during Curcumin Treatment', 'author': 'Jeong', 'doi-asserted-by': 'publisher', 'first-page': '184', 'journal-title': 'Fish Shellfish Immunol.', 'key': 'B59', 'volume': '45', 'year': '2015'}, { 'DOI': '10.1016/j.intimp.2018.12.017', 'article-title': 'Rapamycin Ameliorates Lipopolysaccharide-Induced Acute Lung Injury by ' 'Inhibiting IL-1β and IL-18 Production', 'author': 'Jia', 'doi-asserted-by': 'publisher', 'first-page': '211', 'journal-title': 'Int. Immunopharmacology', 'key': 'B60', 'volume': '67', 'year': '2019'}, { 'DOI': '10.1126/science.aam8897', 'article-title': 'Host DNases Prevent Vascular Occlusion by Neutrophil Extracellular ' 'Traps', 'author': 'Jiménez-Alcázar', 'doi-asserted-by': 'publisher', 'first-page': '1202', 'journal-title': 'Science', 'key': 'B61', 'volume': '358', 'year': '2017'}, { 'article-title': 'Curcumin Inhibits Proliferation of Colorectal Carcinoma by Modulating ' 'Akt/mTOR Signaling', 'author': 'Johnson', 'first-page': '3185', 'journal-title': 'Anticancer Res.', 'key': 'B62', 'volume': '29', 'year': '2009'}, { 'DOI': '10.1007/s00280-010-1470-2', 'article-title': 'A Phase I/II Study of Gemcitabine-Based Chemotherapy Plus Curcumin for ' 'Patients with Gemcitabine-Resistant Pancreatic Cancer', 'author': 'Kanai', 'doi-asserted-by': 'publisher', 'first-page': '157', 'journal-title': 'Cancer Chemother. Pharmacol.', 'key': 'B63', 'volume': '68', 'year': '2011'}, { 'DOI': '10.1016/j.febslet.2006.11.046', 'article-title': 'Augmentation of Chemokine Production by Severe Acute Respiratory ' 'Syndrome Coronavirus 3a/X1 and 7a/X4 Proteins through NF-Κb Activation', 'author': 'Kanzawa', 'doi-asserted-by': 'publisher', 'first-page': '6807', 'journal-title': 'FEBS Lett.', 'key': 'B64', 'volume': '580', 'year': '2006'}, { 'DOI': '10.3389/fnmol.2015.00024', 'article-title': 'Plant Polyphenols as Inhibitors of NF-Îob Induced Cytokine ' 'Productionâ€"a Potential Anti-inflammatory Treatment for Alzheimer\'s ' 'Disease?', 'author': 'Karunaweera', 'doi-asserted-by': 'publisher', 'first-page': '1', 'journal-title': 'Front. Mol. Neurosci.', 'key': 'B65', 'volume': '8', 'year': '2015'}, { 'DOI': '10.3389/fphar.2020.595888', 'article-title': 'Role of Endolysosomes in Severe Acute Respiratory Syndrome ' 'Coronavirus-2 Infection and Coronavirus Disease 2019 Pathogenesis: ' 'Implications for Potential Treatments', 'author': 'Khan', 'doi-asserted-by': 'publisher', 'first-page': '1', 'journal-title': 'Front. Pharmacol.', 'key': 'B66', 'volume': '11', 'year': '2020'}, { 'DOI': '10.1038/nm1267', 'article-title': 'A Crucial Role of Angiotensin Converting Enzyme 2 (ACE2) in SARS ' 'Coronavirus-Induced Lung Injury', 'author': 'Kuba', 'doi-asserted-by': 'publisher', 'first-page': '875', 'journal-title': 'Nat. Med.', 'key': 'B67', 'volume': '11', 'year': '2005'}, { 'DOI': '10.1016/j.ahj.2020.04.025', 'article-title': 'A Current Review of COVID-19 for the Cardiovascular Specialist', 'author': 'Lang', 'doi-asserted-by': 'publisher', 'first-page': '29', 'journal-title': 'Am. Heart J.', 'key': 'B68', 'volume': '226', 'year': '2020'}, { 'DOI': '10.1172/jci.insight.98178', 'article-title': 'Maladaptive Role of Neutrophil Extracellular Traps in Pathogen-Induced ' 'Lung Injury', 'author': 'Lefrançais', 'doi-asserted-by': 'publisher', 'first-page': '1', 'journal-title': 'JCI Insight', 'key': 'B69', 'volume': '3', 'year': '2018'}, { 'DOI': '10.1038/s41591-020-0901-9', 'article-title': 'Single-cell Landscape of Bronchoalveolar Immune Cells in Patients with ' 'COVID-19', 'author': 'Liao', 'doi-asserted-by': 'publisher', 'first-page': '842', 'journal-title': 'Nat. Med.', 'key': 'B71', 'volume': '26', 'year': '2020'}, { 'DOI': '10.1111/j.1745-7270.2005.00082.x', 'article-title': 'Activation of NF-kappaB by the Full-Length Nucleocapsid Protein of the ' 'SARS Coronavirus', 'author': 'Liao', 'doi-asserted-by': 'publisher', 'first-page': '607', 'journal-title': 'Acta Biochim. Biophys. Sinica', 'key': 'B70', 'volume': '37', 'year': '2005'}, { 'DOI': '10.3389/fimmu.2018.01545', 'article-title': 'Regulatory T Cells and Acute Lung Injury: Cytokines, Uncontrolled ' 'Inflammation, and Therapeutic Implications', 'author': 'Lin', 'doi-asserted-by': 'publisher', 'first-page': '1', 'journal-title': 'Front. Immunol.', 'key': 'B73', 'volume': '9', 'year': '2018'}, { 'DOI': '10.1007/s12603-016-0722-1', 'article-title': 'Efficacy and Therapeutic Potential of Curcumin against Sepsis-Induced ' 'Chronic Lung Injury in Male Albino Rats', 'author': 'Liu', 'doi-asserted-by': 'publisher', 'first-page': '307', 'journal-title': 'J. Nutr. Health Aging', 'key': 'B74', 'volume': '21', 'year': '2017'}, { 'DOI': '10.1016/S0140-6736(20)30251-8', 'article-title': 'Genomic Characterisation and Epidemiology of 2019 Novel Coronavirus: ' 'Implications for Virus Origins and Receptor Binding', 'author': 'Lu', 'doi-asserted-by': 'publisher', 'first-page': '565', 'journal-title': 'The Lancet', 'key': 'B75', 'volume': '395', 'year': '2020'}, { 'DOI': '10.1016/j.etap.2014.04.017', 'article-title': 'Protective Effect of Curcumin against Cytomegalovirus Infection in ' 'Balb/c Mice', 'author': 'Lv', 'doi-asserted-by': 'publisher', 'first-page': '1140', 'journal-title': 'Environ. Toxicol. Pharmacol.', 'key': 'B77', 'volume': '37', 'year': ''}, { 'article-title': 'The Effect of Curcumin on NF-Κb Expression in Rat with Lumbar ' 'Intervertebral Disc Degeneration', 'author': 'Ma', 'first-page': '1305', 'journal-title': 'Eur. Rev. Med. Pharmacol. Sci.', 'key': 'B78', 'volume': '19', 'year': '2015'}, { 'DOI': '10.1016/j.cyto.2020.155151', 'article-title': 'COVID-19 Cytokine Storm: The Anger of Inflammation', 'author': 'Mahmudpour', 'doi-asserted-by': 'publisher', 'first-page': '155151', 'journal-title': 'Cytokine', 'key': 'B79', 'volume': '133', 'year': '2020'}, { 'DOI': '10.1007/s12291-020-00902-9', 'article-title': 'Curcumin: a Wonder Drug as a Preventive Measure for COVID19 Management', 'author': 'Manoharan', 'doi-asserted-by': 'publisher', 'first-page': '373', 'journal-title': 'Ind. J. Clin. Biochem.', 'key': 'B80', 'volume': '35', 'year': '2020'}, { 'DOI': '10.1183/13993003.00607-2020', 'article-title': 'Pathogenesis of COVID-19 from a Cell Biology Perspective', 'author': 'Mason', 'doi-asserted-by': 'publisher', 'first-page': '2000607', 'journal-title': 'Eur. Respir. J.', 'key': 'B81', 'volume': '55', 'year': '2020'}, { 'DOI': '10.1007/s13337-020-00598-8', 'article-title': 'Structure-based Drug Designing for Potential Antiviral Activity of ' 'Selected Natural Products from Ayurveda against SARS-CoV-2 Spike ' 'Glycoprotein and its Cellular Receptor', 'author': 'Maurya', 'doi-asserted-by': 'publisher', 'first-page': '179', 'journal-title': 'VirusDis.', 'key': 'B82', 'volume': '31', 'year': '2020'}, { 'DOI': '10.3109/09537100903528269', 'article-title': 'Curcumin Inhibits GPVI-Mediated Platelet Activation by Interfering with ' 'the Kinase Activity of Syk and the Subsequent Activation of PLCγ2', 'author': 'Mayanglambam', 'doi-asserted-by': 'publisher', 'first-page': '211', 'journal-title': 'Platelets', 'key': 'B83', 'volume': '21', 'year': '2010'}, { 'DOI': '10.1161/CIRCRESAHA.120.317447', 'article-title': 'The Emerging Threat of (Micro)Thrombosis in COVID-19 and its ' 'Therapeutic Implications', 'author': 'McFadyen', 'doi-asserted-by': 'publisher', 'first-page': '571', 'journal-title': 'Circ. Res.', 'key': 'B84', 'volume': '127', 'year': '2020'}, { 'DOI': '10.1182/blood.2020007008', 'article-title': 'Neutrophil Extracellular Traps Contribute to Immunothrombosis in ' 'COVID-19 Acute Respiratory Distress Syndrome', 'author': 'Middleton', 'doi-asserted-by': 'publisher', 'first-page': '1169', 'journal-title': 'Blood', 'key': 'B85', 'volume': '136', 'year': '2020'}, { 'DOI': '10.36922/itps.v3i2.935', 'article-title': 'In Silico Study of Curcumin and Folic Acid as Potent Inhibitors of ' 'Human Transmembrane Protease Serine 2 in the Treatment of COVID-19', 'author': 'Motohashi', 'doi-asserted-by': 'publisher', 'first-page': '3', 'journal-title': 'INNOSC Theranostics Pharmacol. Sci.', 'key': 'B86', 'volume': '3', 'year': '2020'}, { 'DOI': '10.1016/j.antiviral.2017.03.014', 'article-title': 'Curcumin Inhibits Zika and Chikungunya Virus Infection by Inhibiting ' 'Cell Binding', 'author': 'Mounce', 'doi-asserted-by': 'publisher', 'first-page': '148', 'journal-title': 'Antiviral Res.', 'key': 'B87', 'volume': '142', 'year': '2017'}, { 'DOI': '10.1016/j.immuni.2019.03.027', 'article-title': 'Pleiotropy and Specificity: Insights from the Interleukin 6 Family of ' 'Cytokines', 'author': 'Murakami', 'doi-asserted-by': 'publisher', 'first-page': '812', 'journal-title': 'Immunity', 'key': 'B88', 'volume': '50', 'year': '2019'}, { 'DOI': '10.1371/journal.pone.0039554', 'article-title': 'Protective Effect of Curcumin on Pulmonary and Cardiovascular Effects ' 'Induced by Repeated Exposure to Diesel Exhaust Particles in Mice', 'author': 'Nemmar', 'doi-asserted-by': 'publisher', 'first-page': 'e39554', 'journal-title': 'PLoS One', 'key': 'B89', 'volume': '7', 'year': '2012'}, { 'DOI': '10.1016/j.virol.2015.08.010', 'article-title': 'Severe Acute Respiratory Syndrome Coronavirus E Protein Transports ' 'Calcium Ions and Activates the NLRP3 Inflammasome', 'author': 'Nieto-Torres', 'doi-asserted-by': 'publisher', 'first-page': '330', 'journal-title': 'Virology', 'key': 'B90', 'volume': '485', 'year': '2015'}, { 'DOI': '10.1055/s-0038-1656136', 'article-title': 'Angiotensin II Increases Plasminogen Activator Inhibitor-1 and Tissue ' 'Factor mRNA Expression without Changing that of Tissue Type Plasminogen ' 'Activator or Tissue Factor Pathway Inhibitor in Cultured Rat Aortic ' 'Endothelial Cells', 'author': 'Nishimura', 'doi-asserted-by': 'publisher', 'first-page': '1189', 'journal-title': 'Thromb. Haemost.', 'key': 'B91', 'volume': '77', 'year': '1997'}, { 'DOI': '10.1371/journal.pone.0070225', 'article-title': 'Curcumin Prevents Replication of Respiratory Syncytial Virus and the ' 'Epithelial Responses to it in Human Nasal Epithelial Cells', 'author': 'Obata', 'doi-asserted-by': 'publisher', 'first-page': 'e70225', 'journal-title': 'PLoS One', 'key': 'B92', 'volume': '8', 'year': '2013'}, { 'DOI': '10.1111/febs.12503', 'article-title': 'Structure-activity Relationship Analysis of Curcumin Analogues on ' 'Anti-influenza Virus Activity', 'author': 'Ou', 'doi-asserted-by': 'publisher', 'first-page': '5829', 'journal-title': 'FEBS J.', 'key': 'B93', 'volume': '280', 'year': '2013'}, { 'DOI': '10.1038/s41598-020-57965-0', 'article-title': 'The Dual Role of Curcumin and Ferulic Acid in Counteracting ' 'Chemoresistance and Cisplatin-Induced Ototoxicity', 'author': 'Paciello', 'doi-asserted-by': 'publisher', 'first-page': '1063', 'journal-title': 'Sci. Rep.', 'key': 'B94', 'volume': '10', 'year': '2020'}, { 'DOI': '10.3389/fpubh.2020.00432', 'article-title': 'D-dimer Concentrations and COVID-19 Severity: A Systematic Review and ' 'Meta-Analysis', 'author': 'Paliogiannis', 'doi-asserted-by': 'publisher', 'first-page': '1', 'journal-title': 'Front. Public Health', 'key': 'B95', 'volume': '8', 'year': '2020'}, { 'DOI': '10.1038/nri.2017.105', 'article-title': 'Neutrophil Extracellular Traps in Immunity and Disease', 'author': 'Papayannopoulos', 'doi-asserted-by': 'publisher', 'first-page': '134', 'journal-title': 'Nat. Rev. Immunol.', 'key': 'B96', 'volume': '18', 'year': '2018'}, { 'DOI': '10.1248/bpb.b12-00623', 'article-title': 'Diarylheptanoids from Alnus Japonica Inhibit Papain-like Protease of ' 'Severe Acute Respiratory Syndrome Coronavirus', 'author': 'Park', 'doi-asserted-by': 'publisher', 'first-page': '2036', 'journal-title': 'Biol. Pharm. Bull.', 'key': 'B97', 'volume': '35', 'year': '2012'}, { 'DOI': '10.1016/j.bmc.2012.07.038', 'article-title': 'Tanshinones as Selective and Slow-Binding Inhibitors for SARS-CoV ' 'Cysteine Proteases', 'author': 'Park', 'doi-asserted-by': 'publisher', 'first-page': '5928', 'journal-title': 'Bioorg. Med. Chem.', 'key': 'B98', 'volume': '20', 'year': '2012'}, { 'DOI': '10.1182/blood.2020007938', 'article-title': 'Postdischarge Thrombosis and Hemorrhage in Patients with COVID-19', 'author': 'Patell', 'doi-asserted-by': 'publisher', 'first-page': '1342', 'journal-title': 'Blood', 'key': 'B99', 'volume': '136', 'year': '2020'}, { 'DOI': '10.1161/01.ATV.17.12.3406', 'article-title': 'Inhibition of Tissue Factor Gene Activation in Cultured Endothelial ' 'Cells by Curcumin', 'author': 'Pendurthi', 'doi-asserted-by': 'publisher', 'first-page': '3406', 'journal-title': 'Arterioscler Thromb Vasc Biol.', 'key': 'B100', 'volume': '17', 'year': '1997'}, { 'DOI': '10.1161/CIRCULATIONAHA.108.814640', 'article-title': 'Reperfusion Injury, Microvascular Dysfunction, and Cardioprotection', 'author': 'Prasad', 'doi-asserted-by': 'publisher', 'first-page': '2105', 'journal-title': 'Circulation', 'key': 'B101', 'volume': '120', 'year': '2009'}, { 'DOI': '10.1016/j.bgm.2014.06.002', 'article-title': 'Curcumin Decreased Level of Proinflammatory Cytokines in Monocyte ' 'Cultures Exposed to Preeclamptic Plasma by Affecting the Transcription ' 'Factors NF-Κb and PPAR-γ', 'author': 'Rahardjo', 'doi-asserted-by': 'publisher', 'first-page': '105', 'journal-title': 'Biomarkers Genomic Med.', 'key': 'B102', 'volume': '6', 'year': '2014'}, { 'DOI': '10.1016/S0047-6374(00)00089-0', 'article-title': 'An Hydroalcoholic Extract of Curcuma Longa Lowers the Abnormally High ' 'Values of Human-Plasma Fibrinogen', 'author': 'Ramirez Boscá', 'doi-asserted-by': 'publisher', 'first-page': '207', 'journal-title': 'Mech. Ageing Dev.', 'key': 'B103', 'volume': '114', 'year': '2000'}, { 'DOI': '10.1016/j.eclinm.2020.100434', 'article-title': 'Megakaryocytes and Platelet-Fibrin Thrombi Characterize Multi-Organ ' 'Thrombosis at Autopsy in COVID-19: A Case Series', 'author': 'Rapkiewicz', 'doi-asserted-by': 'publisher', 'first-page': '100434', 'journal-title': 'EClinicalMedicine', 'key': 'B104', 'volume': '24', 'year': '2020'}, { 'DOI': '10.1016/S0140-6736(20)31094-1', 'article-title': 'Hyperinflammatory Shock in Children during COVID-19 Pandemic', 'author': 'Riphagen', 'doi-asserted-by': 'publisher', 'first-page': '1607', 'journal-title': 'The Lancet', 'key': 'B105', 'volume': '395', 'year': '2020'}, { 'DOI': '10.1084/jem.20201707', 'article-title': 'Inflammasomes Are Activated in Response to SARS-CoV-2 Infection and Are ' 'Associated with COVID-19 Severity in Patients', 'author': 'Rodrigues', 'doi-asserted-by': 'publisher', 'journal-title': 'J. Exp. Med.', 'key': 'B106', 'volume': '218', 'year': '2021'}, { 'DOI': '10.1002/ptr.6766', 'article-title': 'Can Concomitant Use of Zinc and Curcumin with Other Immunity‐boosting ' 'Nutraceuticals Be the Arsenal against COVID ‐19?', 'author': 'Roy', 'doi-asserted-by': 'publisher', 'first-page': '2425', 'journal-title': 'Phytotherapy Res.', 'key': 'B107', 'volume': '34', 'year': '2020'}, { 'DOI': '10.1097/00041552-200105000-00005', 'article-title': 'Proinflammatory Actions of Angiotensins', 'author': 'Ruiz-Ortega', 'doi-asserted-by': 'publisher', 'first-page': '321', 'journal-title': 'Curr. Opin. Nephrol. Hypertens.', 'key': 'B108', 'volume': '10', 'year': '2001'}, { 'DOI': '10.1038/s41589-020-00689-z', 'article-title': 'SARS-CoV-2 Mpro Inhibitors and Activity-Based Probes for Patient-Sample ' 'Imaging', 'author': 'Rut', 'doi-asserted-by': 'publisher', 'first-page': '222', 'journal-title': 'Nat. Chem. Biol.', 'key': 'B109', 'volume': '17', 'year': '2020'}, { 'DOI': '10.1186/s12879-017-2253-8', 'article-title': 'Effective Inhibition of MERS-CoV Infection by Resveratrol', 'author': 'Lin', 'doi-asserted-by': 'publisher', 'first-page': '1', 'journal-title': 'BMC Infect. Dis.', 'key': 'B72', 'volume': '17', 'year': '2017'}, { 'DOI': '10.1111/bcpt.13503', 'article-title': 'COVID-19: A Case for Inhibiting NLRP3 Inflammasome, Suppression of ' 'Inflammation with Curcumin?', 'author': 'Saeedi-Boroujeni', 'doi-asserted-by': 'publisher', 'first-page': '37', 'journal-title': 'Basic Clin. Pharmacol. Toxicol.', 'key': 'B110', 'volume': '128', 'year': '2021'}, { 'DOI': '10.1371/journal.pone.0032366', 'article-title': 'Neutrophil Extracellular Traps Directly Induce Epithelial and ' 'Endothelial Cell Death: A Predominant Role of Histones', 'author': 'Saffarzadeh', 'doi-asserted-by': 'publisher', 'first-page': 'e32366', 'journal-title': 'PLoS One', 'key': 'B111', 'volume': '7', 'year': '2012'}, { 'DOI': '10.4172/2155-9899.1000311', 'article-title': 'Macrophage Polarization in Virus-Host Interactions', 'author': 'Sang', 'doi-asserted-by': 'publisher', 'first-page': '139', 'journal-title': 'J. Clin. Cel. Immunol.', 'key': 'B112', 'volume': '6', 'year': '2015'}, { 'DOI': '10.1590/0001-3765202020200834', 'article-title': 'Hemostatic Abnormalities in Covid-19: A Guided Review', 'author': 'Sathler', 'doi-asserted-by': 'publisher', 'first-page': '1', 'journal-title': 'Acad. Bras. Ciênc.', 'key': 'B113', 'volume': '92', 'year': '2020'}, { 'DOI': '10.1016/j.cell.2017.02.004', 'article-title': 'mTOR Signaling in Growth, Metabolism, and Disease', 'author': 'Saxton', 'doi-asserted-by': 'publisher', 'first-page': '960', 'journal-title': 'Cell', 'key': 'B114', 'volume': '168', 'year': '2017'}, { 'DOI': '10.1056/nejmp2014836', 'article-title': 'Failing the Test - the Tragic Data Gap Undermining the U.S. Pandemic ' 'Response', 'author': 'Schneider', 'doi-asserted-by': 'publisher', 'first-page': '299', 'journal-title': 'N. Engl. J. Med.', 'key': 'B115', 'volume': '383', 'year': '2020'}, { 'DOI': '10.3389/fimmu.2016.00366', 'article-title': 'Neutrophil Extracellular Traps Go Viral', 'author': 'Schönrich', 'doi-asserted-by': 'publisher', 'first-page': '11', 'journal-title': 'Front. Immunol.', 'key': 'B116', 'volume': '7', 'year': '2016'}, { 'DOI': '10.1016/S0006-2952(99)00206-3', 'article-title': 'Inhibitory Effect of Curcumin, a Food Spice from Turmeric, on ' 'Platelet-Activating Factor- and Arachidonic Acid-Mediated Platelet ' 'Aggregation through Inhibition of Thromboxane Formation and Ca2+ ' 'Signaling', 'author': 'Shah', 'doi-asserted-by': 'publisher', 'first-page': '1167', 'journal-title': 'Biochem. Pharmacol.', 'key': 'B117', 'volume': '58', 'year': '1999'}, { 'DOI': '10.1038/s41420-019-0181-7', 'article-title': 'SARS-coronavirus Open Reading Frame-8b Triggers Intracellular Stress ' 'Pathways and Activates NLRP3 Inflammasomes', 'author': 'Shi', 'doi-asserted-by': 'publisher', 'journal-title': 'Cell Death Discov.', 'key': 'B118', 'volume': '5', 'year': '2019'}, { 'DOI': '10.1080/13880209.2016.1260598', 'article-title': 'Curcumin Suppresses Inflammatory Cytokines and Heat Shock Protein 70 ' 'Release and Improves Metabolic Parameters during Experimental Sepsis', 'author': 'Silva', 'doi-asserted-by': 'publisher', 'first-page': '269', 'journal-title': 'Pharm. Biol.', 'key': 'B120', 'volume': '55', 'year': '2017'}, { 'DOI': '10.1016/j.bpa.2015.08.004', 'article-title': 'Mechanisms of Ventilator-Induced Lung Injury in Healthy Lungs', 'author': 'Silva', 'doi-asserted-by': 'publisher', 'first-page': '301', 'journal-title': 'Best Pract. Res. Clin. Anaesthesiology', 'key': 'B119', 'volume': '29', 'year': '2015'}, { 'DOI': '10.1002/oby.22831', 'article-title': 'High Prevalence of Obesity in Severe Acute Respiratory Syndrome ' 'Coronavirus‐2 (SARS‐CoV‐2) Requiring Invasive Mechanical Ventilation', 'author': 'Simonnet', 'doi-asserted-by': 'publisher', 'first-page': '1195', 'journal-title': 'Obesity', 'key': 'B121', 'volume': '28', 'year': '2020'}, { 'DOI': '10.1096/fj.201802418R', 'article-title': 'Severe Acute Respiratory Syndrome Coronavirus ORF3a Protein Activates ' 'the NLRP3 Inflammasome by Promoting TRAF3‐dependent Ubiquitination of ' 'ASC', 'author': 'Siu', 'doi-asserted-by': 'publisher', 'first-page': '8865', 'journal-title': 'FASEB j.', 'key': 'B122', 'volume': '33', 'year': '2019'}, { 'DOI': '10.1161/01.ATV.0000131266.38312.2e', 'article-title': 'Angiotensin II Stimulates the Release of Interleukin-6 and ' 'Interleukin-8 from Cultured Human Adipocytes by Activation of NF-Κb', 'author': 'Skurk', 'doi-asserted-by': 'publisher', 'first-page': '1199', 'journal-title': 'Arterioscler Thromb Vasc Biol.', 'key': 'B123', 'volume': '24', 'year': '2004'}, { 'DOI': '10.1007/s12026-008-8025-1', 'article-title': 'The IκB Kinase Complex: Master Regulator of NF-Κb Signaling', 'author': 'Solt', 'doi-asserted-by': 'publisher', 'first-page': '3', 'journal-title': 'Immunol. Res.', 'key': 'B124', 'volume': '42', 'year': '2008'}, { 'DOI': '10.1016/j.ejphar.2020.173551', 'article-title': 'Curcumin, a Traditional Spice Component, Can Hold the Promise against ' 'COVID-19?', 'author': 'Soni', 'doi-asserted-by': 'publisher', 'first-page': '173551', 'journal-title': 'Eur. J. Pharmacol.', 'key': 'B125', 'volume': '886', 'year': '2020'}, { 'DOI': '10.1016/0952-3278(95)90040-3', 'article-title': 'Curcumin, a Major Component of Food Spice Turmeric (Curcuma longa) ' 'Inhibits Aggregation and Alters Eicosanoid Metabolism in Human Blood ' 'Platelets', 'author': 'Srivastava', 'doi-asserted-by': 'publisher', 'first-page': '223', 'journal-title': 'Prostaglandins, Leukot. Essent. Fatty Acids', 'key': 'B126', 'volume': '52', 'year': '1995'}, { 'DOI': '10.1161/CIRCULATIONAHA.120.047525', 'article-title': 'ST-Elevation Myocardial Infarction in Patients With COVID-19', 'author': 'Stefanini', 'doi-asserted-by': 'publisher', 'first-page': '2113', 'journal-title': 'Circulation', 'key': 'B127', 'volume': '141', 'year': '2020'}, { 'DOI': '10.1002/jcp.30233', 'article-title': 'Immunomodulatory Effects of Nanocurcumin on Th17 Cell Responses in Mild ' 'and Severe COVID‐19 Patients', 'author': 'Tahmasebi', 'doi-asserted-by': 'publisher', 'first-page': '5325', 'journal-title': 'J. Cel. Physiol.', 'key': 'B128', 'volume': '236', 'year': '2020'}, { 'DOI': '10.1111/jth.14768', 'article-title': 'Abnormal Coagulation Parameters Are Associated with Poor Prognosis in ' 'Patients with Novel Coronavirus Pneumonia', 'author': 'Tang', 'doi-asserted-by': 'publisher', 'first-page': '844', 'journal-title': 'J. Thromb. Haemost.', 'key': 'B129', 'volume': '18', 'year': '2020'}, { 'DOI': '10.1016/j.ejphar.2017.02.034', 'article-title': 'Activation of mTOR/IκB-Α/nf-Κb Pathway Contributes to LPS-Induced ' 'Hypotension and Inflammation in Rats', 'author': 'Temiz-Resitoglu', 'doi-asserted-by': 'publisher', 'first-page': '7', 'journal-title': 'Eur. J. Pharmacol.', 'key': 'B130', 'volume': '802', 'year': '2017'}, { 'DOI': '10.4161/cbt.7.9.6469', 'article-title': 'Androgen Responsive and Refractory Prostate Cancer Cells Exhibit ' 'Distinct Curcumin Regulated Transcriptome', 'author': 'Thangapazham', 'doi-asserted-by': 'publisher', 'first-page': '1427', 'journal-title': 'Cancer Biol. Ther.', 'key': 'B131', 'volume': '7', 'year': '2008'}, { 'DOI': '10.1016/j.heliyon.2021.e06350', 'article-title': 'Antiviral and Immunomodulatory Activity of Curcumin: A Case for ' 'Prophylactic Therapy for COVID-19', 'author': 'Thimmulappa', 'doi-asserted-by': 'publisher', 'first-page': 'e06350', 'journal-title': 'Heliyon', 'key': 'B132', 'volume': '7', 'year': '2021'}, { 'DOI': '10.1016/j.intimp.2020.107088', 'article-title': 'Nano-curcumin Therapy, a Promising Method in Modulating Inflammatory ' 'Cytokines in COVID-19 Patients', 'author': 'Valizadeh', 'doi-asserted-by': 'publisher', 'first-page': '107088', 'journal-title': 'Int. Immunopharmacology', 'key': 'B133', 'volume': '89', 'year': '2020'}, { 'DOI': '10.1093/ehjcr/ytab105', 'article-title': 'Persistent Chest Pain after Recovery of COVID-19: Microvascular ' 'Disease-Related Angina?', 'author': 'Vallejo', 'doi-asserted-by': 'publisher', 'first-page': '4', 'journal-title': 'Eur. Hear. J. - Case Rep.', 'key': 'B134', 'volume': '5', 'year': '2021'}, { 'DOI': '10.1007/s00395-005-0523-x', 'article-title': "Postconditioning A New Link in Nature's Armor against Myocardial " 'Ischemia-Reperfusion Injury', 'author': 'Vinten-Johansen', 'doi-asserted-by': 'publisher', 'first-page': '295', 'journal-title': 'Basic Res. Cardiol.', 'key': 'B135', 'volume': '100', 'year': '2005'}, { 'DOI': '10.1016/j.taap.2011.03.002', 'article-title': 'Role of Curcumin-dependent Modulation of Tumor Microenvironment of a ' 'Murine T Cell Lymphoma in Altered Regulation of Tumor Cell Survival', 'author': 'Vishvakarma', 'doi-asserted-by': 'publisher', 'first-page': '298', 'journal-title': 'Toxicol. Appl. Pharmacol.', 'key': 'B136', 'volume': '252', 'year': '2011'}, { 'DOI': '10.1111/j.1476-5381.2012.02109.x', 'article-title': 'Curcumin Promotes Cardiac Repair and Ameliorates Cardiac Dysfunction ' 'Following Myocardial Infarction', 'author': 'Wang', 'doi-asserted-by': 'publisher', 'first-page': '1550', 'journal-title': 'Br. J. Pharmacol.', 'key': 'B137', 'volume': '167', 'year': '2012'}, { 'DOI': '10.1016/j.biopha.2017.12.100', 'article-title': 'Curcumin Ameliorated Ventilator-Induced Lung Injury in Rats', 'author': 'Wang', 'doi-asserted-by': 'publisher', 'first-page': '754', 'journal-title': 'Biomed. Pharmacother.', 'key': 'B138', 'volume': '98', 'year': '2018'}, { 'DOI': '10.1080/08923973.2018.1469145', 'article-title': 'Curcumin as a Therapeutic Agent for Blocking NF-Κb Activation in ' 'Ulcerative Colitis', 'author': 'Wang', 'doi-asserted-by': 'publisher', 'first-page': '476', 'journal-title': 'Immunopharmacology and Immunotoxicology', 'key': 'B139', 'volume': '40', 'year': '2018'}, { 'DOI': '10.1021/jm070295s', 'article-title': 'Specific Plant Terpenoids and Lignoids Possess Potent Antiviral ' 'Activities against Severe Acute Respiratory Syndrome Coronavirus', 'author': 'Wen', 'doi-asserted-by': 'publisher', 'first-page': '4087', 'journal-title': 'J. Med. Chem.', 'key': 'B140', 'volume': '50', 'year': '2007'}, { 'DOI': '10.1126/science.aax090210.1126/science.abb2507', 'article-title': 'Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation', 'author': 'Wrapp', 'doi-asserted-by': 'publisher', 'first-page': '1260', 'journal-title': 'Science', 'key': 'B141', 'volume': '367', 'year': '2020'}, { 'DOI': '10.1073/pnas.0403596101', 'article-title': 'Small Molecules Targeting Severe Acute Respiratory Syndrome Human ' 'Coronavirus', 'author': 'Wu', 'doi-asserted-by': 'publisher', 'first-page': '10012', 'journal-title': 'Proc. Natl. Acad. Sci.', 'key': 'B143', 'volume': '101', 'year': '2004'}, { 'DOI': '10.1001/jama.2020.2648', 'article-title': 'Characteristics of and Important Lessons from the Coronavirus Disease ' '2019 (COVID-19) Outbreak in China', 'author': 'Wu', 'doi-asserted-by': 'publisher', 'first-page': '1239', 'journal-title': 'Jama', 'key': 'B142', 'volume': '323', 'year': '2020'}, { 'DOI': '10.1038/s41422-020-0305-x', 'article-title': 'Inhibition of SARS-CoV-2 (Previously 2019-nCoV) Infection by a Highly ' 'Potent Pan-Coronavirus Fusion Inhibitor Targeting its Spike Protein ' 'that Harbors a High Capacity to Mediate Membrane Fusion', 'author': 'Xia', 'doi-asserted-by': 'publisher', 'first-page': '343', 'journal-title': 'Cell Res', 'key': 'B145', 'volume': '30', 'year': '2020'}, { 'DOI': '10.1038/s41423-020-0374-2', 'article-title': 'Fusion Mechanism of 2019-nCoV and Fusion Inhibitors Targeting HR1 ' 'Domain in Spike Protein', 'author': 'Xia', 'doi-asserted-by': 'publisher', 'first-page': '765', 'journal-title': 'Cell Mol Immunol', 'key': 'B144', 'volume': '17', 'year': '2020'}, { 'DOI': '10.1016/j.jss.2011.11.1032', 'article-title': 'Curcumin Protects against Sepsis-Induced Acute Lung Injury in Rats', 'author': 'Xiao', 'doi-asserted-by': 'publisher', 'first-page': 'e31', 'journal-title': 'J. Surg. Res.', 'key': 'B146', 'volume': '176', 'year': '2012'}, { 'DOI': '10.1016/j.intimp.2013.03.014', 'article-title': 'The Effect of Curcumin on Sepsis-Induced Acute Lung Injury in a Rat ' 'Model through the Inhibition of the TGF-Β1/smad3 Pathway', 'author': 'Xu', 'doi-asserted-by': 'publisher', 'first-page': '1', 'journal-title': 'Int. Immunopharmaco.', 'key': 'B147', 'volume': '16', 'year': '2013'}, { 'DOI': '10.1007/s12291-014-0452-2', 'article-title': 'Curcumin Suppresses the Production of Pro-inflammatory Cytokine ' 'Interleukin-18 in Lipopolysaccharide Stimulated Murine Macrophage-like ' 'Cells', 'author': 'Yadav', 'doi-asserted-by': 'publisher', 'first-page': '109', 'journal-title': 'Ind. J. Clin. Biochem.', 'key': 'B148', 'volume': '30', 'year': '2015'}, { 'DOI': '10.3109/13880209.2012.742116', 'article-title': 'Protective Effect of Curcumin against Cardiac Dysfunction in Sepsis ' 'Rats', 'author': 'Yang', 'doi-asserted-by': 'publisher', 'first-page': '482', 'journal-title': 'Pharm. Biol.', 'key': 'B149', 'volume': '51', 'year': '2013'}, { 'DOI': '10.3390/molecules21101401', 'article-title': 'Curcumin Shows Antiviral Properties against Norovirus', 'author': 'Yang', 'doi-asserted-by': 'publisher', 'first-page': '1401', 'journal-title': 'Molecules', 'key': 'B150', 'volume': '21', 'year': '2016'}, { 'DOI': '10.1039/c5nr07918g', 'article-title': 'Curcumin Modified Silver Nanoparticles for Highly Efficient Inhibition ' 'of Respiratory Syncytial Virus Infection', 'author': 'Yang', 'doi-asserted-by': 'publisher', 'first-page': '3040', 'journal-title': 'Nanoscale', 'key': 'B151', 'volume': '8', 'year': '2016'}, { 'DOI': '10.1038/s41401-020-0485-4', 'article-title': 'Structural and Functional Properties of SARS-CoV-2 Spike Protein: ' 'Potential Antivirus Drug Development for COVID-19', 'author': 'Huang', 'doi-asserted-by': 'publisher', 'first-page': '1', 'journal-title': 'Acta Pharmacol. Sin.', 'key': 'B53', 'volume': '41', 'year': '2020'}, { 'DOI': '10.4049/jimmunol.1701495', 'article-title': 'Curcumin Suppresses IL-1β Secretion and Prevents Inflammation through ' 'Inhibition of the NLRP3 Inflammasome', 'author': 'Yin', 'doi-asserted-by': 'publisher', 'first-page': '2835', 'journal-title': 'J.Immunol.', 'key': 'B152', 'volume': '200', 'year': '2018'}, { 'DOI': '10.1186/1472-6882-14-284', 'article-title': 'Mechanism of Curcumin Resistance to Human Cytomegalovirus in HELF Cells', 'author': 'Lv', 'doi-asserted-by': 'publisher', 'first-page': '1', 'journal-title': 'BMC Complement. Altern. Med.', 'key': 'B76', 'volume': '14', 'year': ''}, { 'DOI': '10.1016/j.transproceed.2020.01.133', 'article-title': 'Curcumin Attenuates Hemorrhagic Shock and Blood Replenish ' 'Resuscitation-Induced Impairment of Pulmonary Barrier Function by ' 'Increasing SIRT1 and Reducing Malondialdehyde and TNF-α Contents and ' 'Neutrophil Infiltration in Lung in a Dose-dependent Fashion', 'author': 'Yu-Wung Yeh', 'doi-asserted-by': 'publisher', 'first-page': '1875', 'journal-title': 'Transplant. Proc.', 'key': 'B153', 'volume': '52', 'year': '2020'}, { 'DOI': '10.1002/ptr.6738', 'article-title': 'Potential Effects of Curcumin in the Treatment of COVID ‐19 Infection', 'author': 'Zahedipour', 'doi-asserted-by': 'publisher', 'first-page': '2911', 'journal-title': 'Phytotherapy Res.', 'key': 'B154', 'volume': '34', 'year': '2020'}, { 'DOI': '10.1111/j.1745-7254.2007.00501.x', 'article-title': 'Curcumin Down Regulates Homeobox Gene NKX3.1 in Prostate Cancer Cell ' 'LNCaP', 'author': 'Zhang', 'doi-asserted-by': 'publisher', 'first-page': '423', 'journal-title': 'Acta Pharmacologica Sinica', 'key': 'B155', 'volume': '28', 'year': '2007'}, { 'DOI': '10.1111/j.1745-7254.2008.00813.x', 'article-title': 'Effect of Curcumin on the Adhesion of Platelets to Brain Microvascular ' 'Endothelial Cellsin Vitro1', 'author': 'Zhang', 'doi-asserted-by': 'publisher', 'first-page': '800', 'journal-title': 'Acta Pharmacol. Sin.', 'key': 'B156', 'volume': '29', 'year': '2008'}, { 'DOI': '10.1126/science.abb3405', 'article-title': 'Crystal Structure of SARS-CoV-2 Main Protease Provides a Basis for ' 'Design of Improved α-ketoamide Inhibitors', 'author': 'Zhang', 'doi-asserted-by': 'publisher', 'first-page': '409', 'journal-title': 'Science', 'key': 'B157', 'volume': '368', 'year': '2020'}, { 'DOI': '10.1186/s13045-020-00954-7', 'article-title': 'SARS-CoV-2 Binds Platelet ACE2 to Enhance Thrombosis in COVID-19', 'author': 'Zhang', 'doi-asserted-by': 'publisher', 'first-page': '120', 'journal-title': 'J. Hematol. Oncol.', 'key': 'B158', 'volume': '13', 'year': '2020'}, { 'DOI': '10.1016/S0140-6736(20)30566-3', 'article-title': 'Clinical Course and Risk Factors for Mortality of Adult Inpatients with ' 'COVID-19 in Wuhan, China: a Retrospective Cohort Study', 'author': 'Zhou', 'doi-asserted-by': 'publisher', 'first-page': '1054', 'journal-title': 'The Lancet', 'key': 'B159', 'volume': '395', 'year': '2020'}, { 'DOI': '10.4149/av_2015_03_221', 'article-title': 'Curcumin Inhibits Bovine Herpesvirus Type 1 Entry into MDBK Cells', 'author': 'Zhu', 'doi-asserted-by': 'publisher', 'first-page': '221', 'journal-title': 'Acta Virol.', 'key': 'B160', 'volume': '59', 'year': '2015'}], 'reference-count': 160, 'references-count': 160, 'relation': {}, 'resource': {'primary': {'URL': 'https://www.frontiersin.org/articles/10.3389/fphar.2021.675287/full'}}, 'score': 1, 'short-title': [], 'source': 'Crossref', 'subject': [], 'subtitle': [], 'title': 'Curcumin as a Potential Treatment for COVID-19', 'type': 'journal-article', 'update-policy': 'http://dx.doi.org/10.3389/crossmark-policy', 'volume': '12'}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit