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Effect of polyphenols against complications of COVID-19: current evidence and potential efficacy

Vajdi et al., Pharmacological Reports, doi:10.1007/s43440-024-00585-6

Mar 2024

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Curcumin for COVID-19

15th treatment shown to reduce risk in February 2021, now with p = 0.0000000096 from 27 studies.

Lower risk for mortality, ventilation, hospitalization, progression, recovery, and viral clearance.

No treatment is 100% effective. Protocols combine treatments.

5,100+ studies for 112 treatments. c19early.org

Review of polyphenols for COVID-19. Authors note that polyphenols can inhibit key SARS-CoV-2 enzymes involved in viral replication and infection, and that many polyphenols have well-established safety profiles. Authors recommend additional research and randomized controlled trials.

Reviews covering curcumin for COVID-19 include1-13.

Important missing comments or errors? Let us know.

Review covers quercetin and curcumin.

1. Rajak et al., Antiallergic Implications of Curcumin During COVID-19: Current Status and Perspectives, Biotechnology of Medicinal Plants with Antiallergy Properties, doi:10.1007/978-981-97-1467-4_4.springer.com, doi.org.

2. Kali et al., Curcumin as a Promising Therapy for COVID-19: A Review, Global Journal of Medical, Pharmaceutical, and Biomedical Update, doi:10.25259/GJMPBU_78_2023.gjmpbu.org, doi.org.

3. Vajdi et al., Effect of polyphenols against complications of COVID-19: current evidence and potential efficacy, Pharmacological Reports, doi:10.1007/s43440-024-00585-6.springer.com, doi.org.

4. Yong et al., Natural Products-Based Inhaled Formulations for Treating Pulmonary Diseases, International Journal of Nanomedicine, doi:10.2147/ijn.s451206.dovepress.com, doi.org.

5. Halma et al., Exploring autophagy in treating SARS-CoV-2 spike protein-related pathology, Endocrine and Metabolic Science, doi:10.1016/j.endmts.2024.100163.sciencedirect.com, doi.org.

6. Arab et al., Immunoregulatory effects of nanocurcumin in inflammatory milieu: Focus on COVID-19, Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2024.116131.sciencedirect.com, doi.org.

7. Daskou et al., The Role of the NRF2 Pathway in the Pathogenesis of Viral Respiratory Infections, Pathogens, doi:10.3390/pathogens13010039.mdpi.com, doi.org.

8. Law et al., Photodynamic Action of Curcumin and Methylene Blue against Bacteria and SARS-CoV-2—A Review, Pharmaceuticals, doi:10.3390/ph17010034.mdpi.com, doi.org.

9. Donzelli, A., Neglected Effective Early Therapies against COVID-19: Focus on Functional Foods and Related Active Substances. A Review, MDPI AG, doi:10.20944/preprints202312.1178.v1.preprints.org, doi.org.

10. Hulscher et al., Clinical Approach to Post-acute Sequelae After COVID-19 Infection and Vaccination, Cureus, doi:10.7759/cureus.49204.cureus.com, doi.org.

11. Hegde et al., Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?, ACS Omega, doi:10.1021/acsomega.2c07326.acs.org, doi.org.

12. Rattis et al., Curcumin as a Potential Treatment for COVID-19, Frontiers in Pharmacology, doi:10.3389/fphar.2021.675287.frontiersin.org, doi.org.

13. Kritis et al., The combination of bromelain and curcumin as an immune-boosting nutraceutical in the prevention of severe COVID-19, Metabolism Open, doi:10.1016/j.metop.2020.100066.sciencedirect.com, doi.org.

Vajdi et al., 18 Mar 2024, peer-reviewed, 9 authors.

This Paper Curcumin All

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' '2007;224:265–73.', 'journal-title': 'Toxicol Appl Pharmacol'}], 'container-title': 'Pharmacological Reports', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1007/s43440-024-00585-6.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1007/s43440-024-00585-6/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1007/s43440-024-00585-6.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 3, 18]], 'date-time': '2024-03-18T07:27:59Z', 'timestamp': 1710746879000}, 'score': 1, 'resource': {'primary': {'URL': 'https://link.springer.com/10.1007/s43440-024-00585-6'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 3, 18]]}, 'references-count': 250, 'alternative-id': ['585'], 'URL': 'http://dx.doi.org/10.1007/s43440-024-00585-6', 'relation': {}, 'ISSN': ['1734-1140', '2299-5684'], 'subject': ['Pharmacology', 'General Medicine'], 'container-title-short': 'Pharmacol. 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