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All Studies   Meta Analysis    Recent:   

Clinical Approach to Post-acute Sequelae After COVID-19 Infection and Vaccination

Hulscher et al., Cureus, doi:10.7759/cureus.49204
Nov 2023  
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Curcumin for COVID-19
15th treatment shown to reduce risk in February 2021
 
*, now known with p = 0.000000046 from 26 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
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Review of evidence that the SARS-CoV-2 spike protein can damage cardiovascular, hematological, neurological, respiratory, gastrointestinal, and immunological systems, and may be a primary cause of long COVID symptoms. Authors introduce a base spike detoxification protocol including oral nattokinase, bromelain, and curcumin to degrade spike protein, inhibit inflammation, dissolve microthrombi, and provide anticoagulation. Authors discuss other treatments that may also be beneficial including HCQ, colchicine, ivermectin, quercetin, glutathione, apigenin, nicotine, emodin, fisetin, rutin, silymarin, and NAC. Authors note that the safety and efficacy of this protocol warrants formal study in large clinical trials.
Reviews covering curcumin for COVID-19 include Arab, Daskou, Halma, Hegde, Hulscher, Kritis, Law, Rattis.
Hulscher et al., 21 Nov 2023, peer-reviewed, 4 authors. Contact: nichulscher@gmail.com.
This PaperCurcuminAll
Clinical Approach to Post-acute Sequelae After COVID-19 Infection and Vaccination
Nicolas Hulscher, Brian C Procter, Cade Wynn, Peter A Mccullough
Cureus, doi:10.7759/cureus.49204
The spike protein of SARS-CoV-2 has been found to exhibit pathogenic characteristics and be a possible cause of post-acute sequelae after SARS-CoV-2 infection or COVID-19 vaccination. COVID-19 vaccines utilize a modified, stabilized prefusion spike protein that may share similar toxic effects with its viral counterpart. The aim of this study is to investigate possible mechanisms of harm to biological systems from SARS-CoV-2 spike protein and vaccine-encoded spike protein and to propose possible mitigation strategies. We searched PubMed, Google Scholar, and 'grey literature' to find studies that (1) investigated the effects of the spike protein on biological systems, (2) helped differentiate between viral and vaccine-generated spike proteins, and (3) identified possible spike protein detoxification protocols and compounds that had signals of benefit and acceptable safety profiles. We found abundant evidence that SARS-CoV-2 spike protein may cause damage in the cardiovascular, hematological, neurological, respiratory, gastrointestinal, and immunological systems. Viral and vaccine-encoded spike proteins have been shown to play a direct role in cardiovascular and thrombotic injuries from both SARS-CoV-2 and vaccination. Detection of spike protein for at least 6-15 months after vaccination and infection in those with post-acute sequelae indicates spike protein as a possible primary contributing factor to long COVID. We rationalized that these findings give support to the potential benefit of spike protein detoxification protocols in those with long-term postinfection and/or vaccine-induced complications. We propose a base spike detoxification protocol, composed of oral nattokinase, bromelain, and curcumin. This approach holds immense promise as a base of clinical care, upon which additional therapeutic agents are applied with the goal of aiding in the resolution of postacute sequelae after SARS-CoV-2 infection and COVID-19 vaccination. Large-scale, prospective, randomized, double-blind, placebo-controlled trials are warranted in order to determine the relative risks and benefits of the base spike detoxification protocol.
Additional Information Author Contributions All authors have reviewed the final version to be published and agreed to be accountable for all aspects of the work. Concept and design:
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