Promising clinical outcomes of nano‐curcumin treatment as an adjunct therapy in hospitalized COVID ‐19 patients: A randomized, double‐blinded, placebo‐controlled trial
et al., Phytotherapy Research, doi:10.1002/ptr.7844, IRCT20170128032241N3
, Promising clinical outcomes of nano‐curcumin treatment as an adjunct therapy in hospitalized COVID .., Phytotherapy Research, doi:10.1002/ptr.7844, IRCT20170128032241N3
RCT 42 hospitalized moderate/severe COVID-19 patients in Iran, showing lower progression and improved recovery with nano-curcumin. Nano-curcumin 70mg bid for 14 days.This is the 19th COVID-19 RCT for curcumin, which collectively show efficacy with p=0.0000049.This is the 24th COVID-19 controlled study for curcumin, which collectively show efficacy with p=0.000000053 (1 in 19 million).
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risk of progression, 92.3% lower, RR 0.08, p = 0.02, treatment 0 of 21 (0.0%), control 6 of 21 (28.6%), NNT 3.5, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
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hospitalization time, 24.5% lower, relative time 0.75, p = 0.007, treatment mean 7.7 (±2.3) n=21, control mean 10.2 (±3.3) n=21.
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relative chest CT score, 67.5% better, RR 0.33, p < 0.001, treatment mean 1.3 (±0.82) n=21, control mean 4.0 (±1.8) n=21, day 14.
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risk of no recovery, 66.7% lower, RR 0.33, p = 0.61, treatment 1 of 21 (4.8%), control 3 of 21 (14.3%), NNT 10, day 14, dyspnea/oxygen need.
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risk of no recovery, 80.0% lower, RR 0.20, p = 0.18, treatment 1 of 21 (4.8%), control 5 of 21 (23.8%), NNT 5.2, day 14, fever.
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risk of no recovery, 85.7% lower, RR 0.14, p = 0.04, treatment 1 of 21 (4.8%), control 7 of 21 (33.3%), NNT 3.5, day 14, cough.
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risk of no recovery, 80.0% lower, RR 0.20, p = 0.49, treatment 0 of 21 (0.0%), control 2 of 21 (9.5%), NNT 10, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 14, headache.
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risk of no recovery, 75.0% lower, RR 0.25, p = 0.34, treatment 1 of 21 (4.8%), control 4 of 21 (19.0%), NNT 7.0, day 14, fatigue.
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risk of no recovery, 75.0% lower, RR 0.25, p = 0.34, treatment 1 of 21 (4.8%), control 4 of 21 (19.0%), NNT 7.0, day 14, myalgia.
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risk of no recovery, 66.7% lower, RR 0.33, p = 1.00, treatment 0 of 21 (0.0%), control 1 of 21 (4.8%), NNT 21, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 14, diarrhea.
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risk of no recovery, 50.0% lower, RR 0.50, p = 1.00, treatment 1 of 21 (4.8%), control 2 of 21 (9.5%), NNT 21, day 14, inappetence.
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risk of no recovery, 66.7% lower, RR 0.33, p = 1.00, treatment 0 of 21 (0.0%), control 1 of 21 (4.8%), NNT 21, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 14, nausea.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Sadeghizadeh et al., 29 Apr 2023, Double Blind Randomized Controlled Trial, placebo-controlled, Iran, peer-reviewed, 12 authors, trial IRCT20170128032241N3.
Late treatment
is less effective
is less effective
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