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Promising clinical outcomes of nano‐curcumin treatment as an adjunct therapy in hospitalized COVID‐19 patients: A randomized, double‐blinded, placebo‐controlled trial

Sadeghizadeh et al., Phytotherapy Research, doi:10.1002/ptr.7844, IRCT20170128032241N3
Apr 2023  
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Progression 92% Improvement Relative Risk Hospitalization time 25% Chest CT score 68% Recovery, dyspnea/oxygen.. 67% Recovery, fever 80% Recovery, cough 86% Recovery, headache 80% Recovery, fatigue 75% Recovery, myalgia 75% Recovery, diarrhea 67% Recovery, inappetence 50% Recovery, nausea 67% Curcumin  Sadeghizadeh et al.  LATE TREATMENT  DB RCT Is late treatment with curcumin beneficial for COVID-19? Double-blind RCT 42 patients in Iran Lower progression (p=0.021) and shorter hospitalization (p=0.0069) c19early.org Sadeghizadeh et al., Phytotherapy Rese.., Apr 2023 Favorscurcumin Favorscontrol 0 0.5 1 1.5 2+
Curcumin for COVID-19
15th treatment shown to reduce risk in February 2021, now with p = 0.0000000096 from 27 studies.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 109 treatments. c19early.org
RCT 42 hospitalized moderate/severe COVID-19 patients in Iran, showing lower progression and improved recovery with nano-curcumin. Nano-curcumin 70mg bid for 14 days.
This is the 18th of 21 COVID-19 RCTs for curcumin, which collectively show efficacy with p=0.0000022.
This is the 24th of 27 COVID-19 controlled studies for curcumin, which collectively show efficacy with p=0.0000000096 (1 in 104 million).
risk of progression, 92.3% lower, RR 0.08, p = 0.02, treatment 0 of 21 (0.0%), control 6 of 21 (28.6%), NNT 3.5, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
hospitalization time, 24.5% lower, relative time 0.75, p = 0.007, treatment mean 7.7 (±2.3) n=21, control mean 10.2 (±3.3) n=21.
relative chest CT score, 67.5% better, RR 0.33, p < 0.001, treatment mean 1.3 (±0.82) n=21, control mean 4.0 (±1.8) n=21, day 14.
risk of no recovery, 66.7% lower, RR 0.33, p = 0.61, treatment 1 of 21 (4.8%), control 3 of 21 (14.3%), NNT 10, day 14, dyspnea/oxygen need.
risk of no recovery, 80.0% lower, RR 0.20, p = 0.18, treatment 1 of 21 (4.8%), control 5 of 21 (23.8%), NNT 5.2, day 14, fever.
risk of no recovery, 85.7% lower, RR 0.14, p = 0.04, treatment 1 of 21 (4.8%), control 7 of 21 (33.3%), NNT 3.5, day 14, cough.
risk of no recovery, 80.0% lower, RR 0.20, p = 0.49, treatment 0 of 21 (0.0%), control 2 of 21 (9.5%), NNT 10, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 14, headache.
risk of no recovery, 75.0% lower, RR 0.25, p = 0.34, treatment 1 of 21 (4.8%), control 4 of 21 (19.0%), NNT 7.0, day 14, fatigue.
risk of no recovery, 75.0% lower, RR 0.25, p = 0.34, treatment 1 of 21 (4.8%), control 4 of 21 (19.0%), NNT 7.0, day 14, myalgia.
risk of no recovery, 66.7% lower, RR 0.33, p = 1.00, treatment 0 of 21 (0.0%), control 1 of 21 (4.8%), NNT 21, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 14, diarrhea.
risk of no recovery, 50.0% lower, RR 0.50, p = 1.00, treatment 1 of 21 (4.8%), control 2 of 21 (9.5%), NNT 21, day 14, inappetence.
risk of no recovery, 66.7% lower, RR 0.33, p = 1.00, treatment 0 of 21 (0.0%), control 1 of 21 (4.8%), NNT 21, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 14, nausea.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sadeghizadeh et al., 29 Apr 2023, Double Blind Randomized Controlled Trial, placebo-controlled, Iran, peer-reviewed, 12 authors, trial IRCT20170128032241N3.
This PaperCurcuminAll
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(2022).Coronavirus (COVID‐19) | Drugs. [cited ' '12/22/2022]; Available ' 'from:https://www.fda.gov/drugs/emergency-preparedness-drugs/coronavirus-covid-19-drugs'}, { 'issue': '1', 'key': 'e_1_2_10_3_1', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1186/s13063-022-06375-w', 'article-title': 'The efficacy of curcumin‐piperine co‐supplementation on clinical ' 'symptoms, duration, severity, and inflammatory factors in COVID‐19 ' 'outpatients: A randomized double‐blind, placebo‐controlled trial', 'volume': '23', 'author': 'Askari G.', 'year': '2022', 'journal-title': 'Trials'}, { 'issue': '2', 'key': 'e_1_2_10_4_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1371/journal.pone.0057285', 'article-title': 'Curcumin modulates the inflammatory response and inhibits subsequent ' 'fibrosis in a mouse model of viral‐induced acute respiratory distress ' 'syndrome', 'volume': '8', 'author': 'Avasarala S.', 'year': '2013', 'journal-title': 'PLoS One'}, { 'key': 'e_1_2_10_5_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.imbio.2022.152236', 'article-title': 'Deciphering the balance of IL‐6/IL‐10 cytokines in severe to critical ' 'COVID‐19 patients', 'volume': '227', 'author': 'Azaiz M. B.', 'year': '2022', 'journal-title': 'Immunobiology'}, { 'key': 'e_1_2_10_6_1', 'doi-asserted-by': 'crossref', 'first-page': '200463', 'DOI': '10.1148/radiol.2020200463', 'article-title': 'Chest CT findings in coronavirus disease‐19 (COVID‐19): Relationship to ' 'duration of infection', 'volume': '295', 'author': 'Bernheim A.', 'year': '2020', 'journal-title': 'Radiology'}, { 'issue': '9', 'key': 'e_1_2_10_7_1', 'doi-asserted-by': 'crossref', 'first-page': '2706', 'DOI': '10.3390/nu12092706', 'article-title': 'Chlorogenic acid potentiates the anti‐inflammatory activity of curcumin ' 'in LPS‐stimulated THP‐1 cells', 'volume': '12', 'author': 'Bisht A.', 'year': '2020', 'journal-title': 'Nutrients'}, { 'key': 'e_1_2_10_8_1', 'doi-asserted-by': 'crossref', 'first-page': '1787', 'DOI': '10.1056/NEJMoa2001282', 'article-title': 'A trial of lopinavir–ritonavir in adults hospitalized with severe ' 'Covid‐19', 'volume': '382', 'author': 'Cao B.', 'year': '2020', 'journal-title': 'New England Journal of Medicine'}, { 'key': 'e_1_2_10_9_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.biopha.2020.109946', 'article-title': 'Curcumin regulates the differentiation of naïve CD4+ T cells and ' 'activates IL‐10 immune modulation against acute lung injury in mice', 'volume': '125', 'author': 'Chai Y.‐s.', 'year': '2020', 'journal-title': 'Biomedicine & Pharmacotherapy'}, { 'issue': '4', 'key': 'e_1_2_10_10_1', 'doi-asserted-by': 'crossref', 'first-page': '386', 'DOI': '10.1111/imm.13443', 'article-title': 'New‐onset autoimmune phenomena post‐COVID‐19 vaccination', 'volume': '165', 'author': 'Chen Y.', 'year': '2022', 'journal-title': 'Immunology'}, { 'issue': '4', 'key': 'e_1_2_10_11_1', 'doi-asserted-by': 'crossref', 'first-page': '597', 'DOI': '10.1016/j.dsx.2020.05.025', 'article-title': 'Mechanism of inflammatory response in associated comorbidities in ' 'COVID‐19', 'volume': '14', 'author': 'Lucena T. M. C.', 'year': '2020', 'journal-title': 'Diabetes & Metabolic Syndrome: Clinical Research & Reviews'}, { 'issue': '2', 'key': 'e_1_2_10_12_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.heliyon.2021.e06155', 'article-title': 'IL‐6 and IL‐10 as predictors of disease severity in COVID‐19 patients: ' 'Results from meta‐analysis and regression', 'volume': '7', 'author': 'Dhar S. K.', 'year': '2021', 'journal-title': 'Heliyon'}, { 'key': 'e_1_2_10_13_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1177/11772719211013363', 'article-title': 'IL‐6 and other biomarkers associated with poor prognosis in a cohort of ' 'hospitalized patients with COVID‐19 in Madrid', 'volume': '16', 'author': 'Donoso‐Navarro E.', 'year': '2021', 'journal-title': 'Biomarker Insights'}, { 'key': 'e_1_2_10_14_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.biopha.2021.111578', 'article-title': 'Will curcumin nanosystems be the next promising antiviral alternatives ' 'in COVID‐19 treatment trials?', 'volume': '139', 'author': 'Dourado D.', 'year': '2021', 'journal-title': 'Biomedicine & Pharmacotherapy'}, { 'key': 'e_1_2_10_15_1', 'doi-asserted-by': 'crossref', 'first-page': '5541', 'DOI': '10.2147/IJN.S63762', 'article-title': 'A novel diblock of copolymer of (monomethoxy poly [ethylene ' 'glycol]‐oleate) with a small hydrophobic fraction to make stable ' 'micelles/polymersomes for curcumin delivery to cancer cells', 'volume': '9', 'author': 'Erfani‐Moghadam V.', 'year': '2014', 'journal-title': 'International Journal of Nanomedicine'}, { 'issue': '12', 'key': 'e_1_2_10_16_1', 'doi-asserted-by': 'crossref', 'first-page': '6808', 'DOI': '10.1007/s00330-020-07033-y', 'article-title': 'Chest CT score in COVID‐19 patients: Correlation with disease severity ' 'and short‐term prognosis', 'volume': '30', 'author': 'Francone M.', 'year': '2020', 'journal-title': 'European Radiology'}, { 'issue': '1', 'key': 'e_1_2_10_17_1', 'first-page': '1', 'article-title': 'Co‐delivery of doxorubicin and curcumin with polypeptide nanocarrier ' 'for synergistic lymphoma therapy', 'volume': '10', 'author': 'Guo W.', 'year': '2020', 'journal-title': 'Scientific Reports'}, { 'issue': '1', 'key': 'e_1_2_10_18_1', 'doi-asserted-by': 'crossref', 'first-page': '195', 'DOI': '10.1208/s12248-012-9432-8', 'article-title': 'Therapeutic roles of curcumin: Lessons learned from clinical trials', 'volume': '15', 'author': 'Gupta S. C.', 'year': '2013', 'journal-title': 'The AAPS Journal'}, { 'issue': '1', 'key': 'e_1_2_10_19_1', 'doi-asserted-by': 'crossref', 'first-page': '1123', 'DOI': '10.1080/22221751.2020.1770129', 'article-title': 'Profiling serum cytokines in COVID‐19 patients reveals IL‐6 and IL‐10 ' 'are disease severity predictors', 'volume': '9', 'author': 'Han H.', 'year': '2020', 'journal-title': 'Emerging Microbes & Infections'}, { 'issue': '11', 'key': 'e_1_2_10_20_1', 'doi-asserted-by': 'crossref', 'first-page': '6417', 'DOI': '10.1002/ptr.7294', 'article-title': 'A triple‐blind, placebo‐controlled, randomized clinical trial to ' 'evaluate the effect of curcumin‐containing nanomicelles on cellular ' 'immune responses subtypes and clinical outcome in COVID‐19 patients', 'volume': '35', 'author': 'Hassaniazad M.', 'year': '2021', 'journal-title': 'Phytotherapy Research'}, { 'issue': '7', 'key': 'e_1_2_10_21_1', 'doi-asserted-by': 'crossref', 'first-page': '1021', 'DOI': '10.1515/cclm-2020-0369', 'article-title': 'Hematologic, biochemical and immune biomarker abnormalities associated ' 'with severe illness and mortality in coronavirus disease 2019 ' '(COVID‐19): A meta‐analysis', 'volume': '58', 'author': 'Henry B. M.', 'year': '2020', 'journal-title': 'Clinical Chemistry and Laboratory Medicine (CCLM)'}, { 'issue': '10', 'key': 'e_1_2_10_22_1', 'doi-asserted-by': 'crossref', 'first-page': '92', 'DOI': '10.3390/foods6100092', 'article-title': 'Curcumin: A review of its effects on human health', 'volume': '6', 'author': 'Hewlings S. J.', 'year': '2017', 'journal-title': 'Food'}, { 'key': 'e_1_2_10_23_1', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1016/j.virol.2020.08.011', 'article-title': 'The novel coronavirus Disease‐2019 (COVID‐19): Mechanism of action, ' 'detection and recent therapeutic strategies', 'volume': '551', 'author': 'Hosseini E. S.', 'year': '2020', 'journal-title': 'Virology'}, { 'key': 'e_1_2_10_24_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.ejmech.2020.113072', 'article-title': 'Synergistic effects of curcumin and its analogs with other bioactive ' 'compounds: A comprehensive review', 'volume': '210', 'author': 'Hosseini‐Zare M. S.', 'year': '2021', 'journal-title': 'European Journal of Medicinal Chemistry'}, { 'issue': '4', 'key': 'e_1_2_10_25_1', 'doi-asserted-by': 'crossref', 'first-page': '459', 'DOI': '10.1007/s13318-019-00545-z', 'article-title': 'Enhancing curcumin oral bioavailability through nanoformulations', 'volume': '44', 'author': 'Ipar V. S.', 'year': '2019', 'journal-title': 'European Journal of Drug Metabolism and Pharmacokinetics'}, { 'key': 'e_1_2_10_26_1', 'doi-asserted-by': 'crossref', 'first-page': '677008', 'DOI': '10.3389/fimmu.2021.677008', 'article-title': 'Elevated interleukin‐10 levels in COVID‐19: Potentiation of ' 'pro‐inflammatory responses or impaired anti‐inflammatory action?', 'volume': '12', 'author': 'Islam H.', 'year': '2021', 'journal-title': 'Frontiers in Immunology'}, { 'issue': '6', 'key': 'e_1_2_10_27_1', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1208/s12249-020-01756-3', 'article-title': 'Diagnostic and treatment strategies for COVID‐19', 'volume': '21', 'author': 'Jamshaid H.', 'year': '2020', 'journal-title': 'AAPS PharmSciTech'}, { 'key': 'e_1_2_10_28_1', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fphar.2022.898062', 'article-title': 'Oral Co‐supplementation of curcumin, quercetin, and vitamin D3 as an ' 'adjuvant therapy for mild to moderate symptoms of COVID‐19—Results from ' 'a pilot open‐label, randomized controlled trial', 'volume': '13', 'author': 'Khan A.', 'year': '2022', 'journal-title': 'Frontiers in Pharmacology'}, { 'issue': '6', 'key': 'e_1_2_10_29_1', 'doi-asserted-by': 'crossref', 'first-page': '2575', 'DOI': '10.1007/s12325-020-01351-9', 'article-title': 'Anti COVID‐19 drugs: Need for more clinical evidence and global action', 'volume': '37', 'author': 'Khan Z.', 'year': '2020', 'journal-title': 'Advances in Therapy'}, { 'issue': '11', 'key': 'e_1_2_10_30_1', 'doi-asserted-by': 'crossref', 'first-page': '1325', 'DOI': '10.1111/bph.13621', 'article-title': 'Curcumin, the golden nutraceutical: Multitargeting for multiple chronic ' 'diseases', 'volume': '174', 'author': 'Kunnumakkara A. B.', 'year': '2017', 'journal-title': 'British Journal of Pharmacology'}, { 'key': 'e_1_2_10_31_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.lfs.2021.119201', 'article-title': 'COVID‐19, cytokines, inflammation, and spices: How are they related?', 'volume': '284', 'author': 'Kunnumakkara A. B.', 'year': '2021', 'journal-title': 'Life Sciences'}, { 'key': 'e_1_2_10_32_1', 'doi-asserted-by': 'crossref', 'first-page': '133', 'DOI': '10.1016/j.phrs.2016.11.017', 'article-title': 'Curcumin use in pulmonary diseases: State of the art and future ' 'perspectives', 'volume': '115', 'author': 'Lelli D.', 'year': '2017', 'journal-title': 'Pharmacological Research'}, { 'key': 'e_1_2_10_33_1', 'doi-asserted-by': 'crossref', 'first-page': '479', 'DOI': '10.3389/fcell.2020.00479', 'article-title': 'The inhibitory effect of curcumin on virus‐induced cytokine storm and ' 'its potential use in the associated severe pneumonia', 'volume': '8', 'author': 'Liu Z.', 'year': '2020', 'journal-title': 'Frontiers in Cell and Developmental Biology'}, { 'issue': '2', 'key': 'e_1_2_10_34_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.bbadis.2021.166294', 'article-title': 'Repositioning ivermectin for Covid‐19 treatment: Molecular mechanisms ' 'of action against SARS‐CoV‐2 replication', 'volume': '1868', 'author': 'Low Z. Y.', 'year': '2022', 'journal-title': 'Biochimica et Biophysica Acta (BBA)‐Molecular Basis of Disease'}, { 'issue': '1', 'key': 'e_1_2_10_35_1', 'doi-asserted-by': 'crossref', 'first-page': '3', 'DOI': '10.1111/ane.13417', 'article-title': 'The potential neurological effect of the COVID‐19 vaccines: A review', 'volume': '144', 'author': 'Lu L.', 'year': '2021', 'journal-title': 'Acta Neurologica Scandinavica'}, { 'issue': '1', 'key': 'e_1_2_10_36_1', 'doi-asserted-by': 'crossref', 'first-page': '3', 'DOI': '10.1016/j.it.2020.10.012', 'article-title': 'A potential role of interleukin 10 in COVID‐19 pathogenesis', 'volume': '42', 'author': 'Lu L.', 'year': '2021', 'journal-title': 'Trends in Immunology'}, { 'issue': '10224', 'key': 'e_1_2_10_37_1', 'doi-asserted-by': 'crossref', 'first-page': '565', 'DOI': '10.1016/S0140-6736(20)30251-8', 'article-title': 'Genomic characterisation and epidemiology of 2019 novel coronavirus: ' 'Implications for virus origins and receptor binding', 'volume': '395', 'author': 'Lu R.', 'year': '2020', 'journal-title': 'The Lancet'}, { 'key': 'e_1_2_10_38_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.cyto.2021.155507', 'article-title': 'IL‐6 and IL‐10 are associated with disease severity and higher ' 'comorbidity in adults with COVID‐19', 'volume': '143', 'author': 'Luporini R. L.', 'year': '2021', 'journal-title': 'Cytokine'}, { 'key': 'e_1_2_10_39_1', 'doi-asserted-by': 'crossref', 'first-page': '692', 'DOI': '10.1016/j.jff.2017.12.017', 'article-title': 'Antiviral potential of curcumin', 'volume': '40', 'author': 'Mathew D.', 'year': '2018', 'journal-title': 'Journal of Functional Foods'}, { 'issue': '4', 'key': 'e_1_2_10_40_1', 'first-page': '252', 'article-title': 'Acute lung injury and the acute respiratory distress syndrome: ' 'Pathophysiology and treatment', 'volume': '107', 'author': 'Matuschak G. M.', 'year': '2010', 'journal-title': 'Missouri Medicine'}, { 'key': 'e_1_2_10_41_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.ebiom.2020.103026', 'article-title': 'A linear prognostic score based on the ratio of interleukin‐6 to ' 'interleukin‐10 predicts outcomes in COVID‐19', 'volume': '61', 'author': 'McElvaney O. J.', 'year': '2020', 'journal-title': 'eBioMedicine'}, { 'key': 'e_1_2_10_42_1', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1016/j.jconrel.2016.01.018', 'article-title': 'Exploring the use of nanocarrier systems to deliver the magical ' 'molecule; curcumin and its derivatives', 'volume': '225', 'author': 'Mehanny M.', 'year': '2016', 'journal-title': 'Journal of Controlled Release'}, { 'key': 'e_1_2_10_43_1', 'doi-asserted-by': 'crossref', 'first-page': '156', 'DOI': '10.1016/j.neuropharm.2015.07.013', 'article-title': 'Polymerized nano‐curcumin attenuates neurological symptoms in EAE model ' 'of multiple sclerosis through down regulation of inflammatory and ' 'oxidative processes and enhancing neuroprotection and myelin repair', 'volume': '99', 'author': 'Mohajeri M.', 'year': '2015', 'journal-title': 'Neuropharmacology'}, { 'key': 'e_1_2_10_44_1', 'doi-asserted-by': 'crossref', 'first-page': '148', 'DOI': '10.1016/j.antiviral.2017.03.014', 'article-title': 'Curcumin inhibits zika and chikungunya virus infection by inhibiting ' 'cell binding', 'volume': '142', 'author': 'Mounce B. C.', 'year': '2017', 'journal-title': 'Antiviral Research'}, { 'issue': '4', 'key': 'e_1_2_10_45_1', 'doi-asserted-by': 'crossref', 'first-page': '417', 'DOI': '10.1002/jmv.20556', 'article-title': 'Cytokine regulation in SARS coronavirus infection compared to other ' 'respiratory virus infections', 'volume': '78', 'author': 'Okabayashi T.', 'year': '2006', 'journal-title': 'Journal of Medical Virology'}, { 'issue': '1', 'key': 'e_1_2_10_46_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.diagmicrobio.2020.115094', 'article-title': 'Clinical, molecular, and epidemiological characterization of the ' 'SARS‐CoV‐2 virus and the coronavirus disease 2019 (COVID‐19), a ' 'comprehensive literature review', 'volume': '98', 'author': 'Ortiz‐Prado E.', 'year': '2020', 'journal-title': 'Diagnostic Microbiology and Infectious Disease'}, { 'issue': '1147', 'key': 'e_1_2_10_47_1', 'doi-asserted-by': 'crossref', 'first-page': '312', 'DOI': '10.1136/postgradmedj-2020-138577', 'article-title': 'COVID‐19: Current understanding of its pathophysiology, clinical ' 'presentation and treatment', 'volume': '97', 'author': 'Parasher A.', 'year': '2021', 'journal-title': 'Postgraduate Medical Journal'}, { 'issue': '2', 'key': 'e_1_2_10_48_1', 'first-page': '824', 'article-title': 'Curcumin as adjuvant therapy in COVID‐19: Friend or foe?', 'volume': '13', 'author': 'Pawitan J. A.', 'year': '2020', 'journal-title': 'Journal of International Dental and Medical Research'}, { 'key': 'e_1_2_10_49_1', 'doi-asserted-by': 'crossref', 'first-page': '912', 'DOI': '10.3389/fmicb.2019.00912', 'article-title': 'Anti‐infective properties of the golden spice curcumin', 'volume': '10', 'author': 'Praditya D.', 'year': '2019', 'journal-title': 'Frontiers in Microbiology'}, { 'key': 'e_1_2_10_50_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.tmaid.2020.101619', 'article-title': 'Positive result of Sars‐Cov‐2 in sputum from a cured patient with ' 'COVID‐19', 'volume': '34', 'author': 'Qu Y.‐M.', 'year': '2020', 'journal-title': 'Travel Medicine and Infectious Disease'}, { 'key': 'e_1_2_10_51_1', 'volume-title': 'Features, evaluation, and treatment of coronavirus (COVID‐19)', 'author': 'Rajnik M.', 'year': '2021'}, { 'issue': '5', 'key': 'e_1_2_10_52_1', 'doi-asserted-by': 'crossref', 'first-page': '846', 'DOI': '10.1007/s00134-020-05991-x', 'article-title': 'Clinical predictors of mortality due to COVID‐19 based on an analysis ' 'of data of 150 patients from Wuhan, China', 'volume': '46', 'author': 'Ruan Q.', 'year': '2020', 'journal-title': 'Intensive Care Medicine'}, { 'issue': '5', 'key': 'e_1_2_10_53_1', 'doi-asserted-by': 'crossref', 'first-page': '2616', 'DOI': '10.1002/ptr.7004', 'article-title': 'Oral nano‐curcumin formulation efficacy in management of mild to ' 'moderate hospitalized coronavirus disease‐19 patients: An open label ' 'nonrandomized clinical trial', 'volume': '35', 'author': 'Saber‐Moghaddam N.', 'year': '2021', 'journal-title': 'Phytotherapy Research'}, { 'issue': '5', 'key': 'e_1_2_10_54_1', 'doi-asserted-by': 'crossref', 'first-page': '2149', 'DOI': '10.4103/jfmpc.jfmpc_728_20', 'article-title': 'Preventive and treatment strategies of COVID‐19: From community to ' 'clinical trials', 'volume': '9', 'author': 'Sahu K. K.', 'year': '2020', 'journal-title': 'Journal of Family Medicine and Primary Care'}, { 'issue': '5', 'key': 'e_1_2_10_55_1', 'doi-asserted-by': 'crossref', 'first-page': '268', 'DOI': '10.1016/j.jdmv.2020.05.003', 'article-title': 'Association between D‐dimer levels and mortality in patients with ' 'coronavirus disease 2019 (COVID‐19): A systematic review and pooled ' 'analysis', 'volume': '45', 'author': 'Sakka M.', 'year': '2020', 'journal-title': 'JMV‐Journal de Médecine Vasculaire'}, { 'issue': '21', 'key': 'e_1_2_10_56_1', 'doi-asserted-by': 'crossref', 'first-page': '10815', 'DOI': '10.1039/c3ra46396f', 'article-title': 'Curcumin, a promising anti‐cancer therapeutic: A review of its chemical ' 'properties, bioactivity and approaches to cancer cell delivery', 'volume': '4', 'author': 'Salem M.', 'year': '2014', 'journal-title': 'RSC Advances'}, { 'key': 'e_1_2_10_57_1', 'doi-asserted-by': 'crossref', 'first-page': '597', 'DOI': '10.1146/annurev-food-032818-121738', 'article-title': 'Curcumin: Recent advances in the development of strategies to improve ' 'oral bioavailability', 'volume': '10', 'author': 'Sanidad K. Z.', 'year': '2019', 'journal-title': 'Annual Review of Food Science and Technology'}, { 'key': 'e_1_2_10_58_1', 'doi-asserted-by': 'crossref', 'first-page': '1021', 'DOI': '10.3389/fphar.2020.01021', 'article-title': 'Turmeric and its major compound curcumin on health: Bioactive effects ' 'and safety profiles for food, pharmaceutical, biotechnological and ' 'medicinal applications', 'volume': '11', 'author': 'Sharifi‐Rad J.', 'year': '2020', 'journal-title': 'Frontiers in Pharmacology'}, { 'key': 'e_1_2_10_59_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1136/postgradmedj-2020-137785', 'article-title': 'Hydroxychloroquine and COVID‐19', 'volume': '96', 'author': 'Sinha N.', 'year': '2020', 'journal-title': 'Postgraduate Medical Journal'}, { 'issue': '6', 'key': 'e_1_2_10_60_1', 'doi-asserted-by': 'crossref', 'first-page': '543', 'DOI': '10.1007/s10565-016-9354-9', 'article-title': 'Curcumin confers protection to irradiated THP‐1 cells while its ' 'nanoformulation sensitizes these cells via apoptosis induction', 'volume': '32', 'author': 'Soltani B.', 'year': '2016', 'journal-title': 'Cell Biology and Toxicology'}, { 'key': 'e_1_2_10_61_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.ejphar.2020.173551', 'article-title': 'Curcumin, a traditional spice component, can hold the promise against ' 'COVID‐19?', 'volume': '886', 'author': 'Soni V. K.', 'year': '2020', 'journal-title': 'European Journal of Pharmacology'}, { 'issue': '1', 'key': 'e_1_2_10_62_1', 'first-page': '1', 'article-title': 'Curcumin suppression of cytokine release and cytokine storm. A ' 'potential therapy for patients with Ebola and other severe viral ' 'infections', 'volume': '29', 'author': 'Sordillo P. P.', 'year': '2015', 'journal-title': 'Vivo'}, { 'issue': '7', 'key': 'e_1_2_10_63_1', 'doi-asserted-by': 'crossref', 'first-page': '2085', 'DOI': '10.1007/s10067-020-05190-5', 'article-title': 'Cytokine storm in COVID‐19: Pathogenesis and overview of ' 'anti‐inflammatory agents used in treatment', 'volume': '39', 'author': 'Soy M.', 'year': '2020', 'journal-title': 'Clinical Rheumatology'}, { 'issue': '60', 'key': 'e_1_2_10_64_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1126/sciimmunol.abj9256', 'article-title': 'COVID‐19 vaccine side effects: The positives about feeling bad', 'volume': '6', 'author': 'Sprent J.', 'year': '2021', 'journal-title': 'Science Immunology'}, { 'issue': '3', 'key': 'e_1_2_10_65_1', 'doi-asserted-by': 'crossref', 'first-page': '331', 'DOI': '10.1016/j.intimp.2010.08.014', 'article-title': 'Immunomodulatory and therapeutic activity of curcumin', 'volume': '11', 'author': 'Srivastava R. M.', 'year': '2011', 'journal-title': 'International Immunopharmacology'}, { 'key': 'e_1_2_10_66_1', 'article-title': 'Signs and symptoms to determine if a patient presenting in primary care ' 'or hospital outpatient settings has COVID‐19', 'volume': '2', 'author': 'Struyf T.', 'year': '2022', 'journal-title': 'Cochrane Database of Systematic Reviews'}, { 'issue': '6', 'key': 'e_1_2_10_67_1', 'doi-asserted-by': 'crossref', 'first-page': '415', 'DOI': '10.1016/S0968-0896(00)82152-5', 'article-title': 'Inhibition of the HIV‐1 and HIV‐2 proteases by curcumin and curcumin ' 'boron complexes', 'volume': '1', 'author': 'Sui Z.', 'year': '1993', 'journal-title': 'Bioorganic & Medicinal Chemistry'}, { 'issue': '7', 'key': 'e_1_2_10_68_1', 'doi-asserted-by': 'crossref', 'first-page': '1085', 'DOI': '10.2217/nnm.12.80', 'article-title': 'Advances in nanotechnology‐based delivery systems for curcumin', 'volume': '7', 'author': 'Sun M.', 'year': '2012', 'journal-title': 'Nanomedicine'}, { 'key': 'e_1_2_10_69_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.heliyon.2021.e06350', 'article-title': 'Antiviral and immunomodulatory activity of curcumin: A case for ' 'prophylactic therapy for COVID‐19', 'volume': '7', 'author': 'Thimmulappa R. K.', 'year': '2021', 'journal-title': 'Heliyon'}, { 'issue': '2', 'key': 'e_1_2_10_70_1', 'doi-asserted-by': 'crossref', 'first-page': '256', 'DOI': '10.3390/nu14020256', 'article-title': 'Effectiveness of curcumin on outcomes of hospitalized COVID‐19 ' 'patients: A systematic review of clinical trials', 'volume': '14', 'author': 'Vahedian‐Azimi A.', 'year': '2022', 'journal-title': 'Nutrients'}, { 'key': 'e_1_2_10_71_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.intimp.2020.107088', 'article-title': 'Nano‐curcumin therapy, a promising method in modulating inflammatory ' 'cytokines in COVID‐19 patients', 'volume': '89', 'author': 'Valizadeh H.', 'year': '2020', 'journal-title': 'International Immunopharmacology'}, { 'key': 'e_1_2_10_72_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.metop.2021.100096', 'article-title': 'Anti‐viral treatment for SARS‐CoV‐2 infection: A race against time ' 'amidst the ongoing pandemic', 'volume': '10', 'author': 'Vallianou N. G.', 'year': '2021', 'journal-title': 'Metabolism Open'}, { 'issue': '15', 'key': 'e_1_2_10_73_1', 'doi-asserted-by': 'crossref', 'first-page': '769', 'DOI': '10.1093/cid/ciaa272', 'article-title': 'Clinical features of 69 cases with coronavirus disease 2019 in Wuhan', 'volume': '71', 'author': 'Wang Z.', 'year': '2020', 'journal-title': 'China. Clinical Infectious Diseases'}, { 'issue': '3', 'key': 'e_1_2_10_74_1', 'doi-asserted-by': 'crossref', 'first-page': '1057', 'DOI': '10.1177/0962280215588241', 'article-title': 'Estimating the sample size for a pilot randomised trial to minimise the ' 'overall trial sample size for the external pilot and main trial for a ' 'continuous outcome variable', 'volume': '25', 'author': 'Whitehead A. L.', 'year': '2016', 'journal-title': 'Statistical Methods in Medical Research'}, { 'issue': '11', 'key': 'e_1_2_10_75_1', 'doi-asserted-by': 'crossref', 'first-page': '5457', 'DOI': '10.3390/ijms22115457', 'article-title': 'Can the COVID‐19 pandemic disrupt the current drug development ' 'practices?', 'volume': '22', 'author': 'Won J.‐H.', 'year': '2021', 'journal-title': 'International Journal of Molecular Sciences'}, { 'key': 'e_1_2_10_76_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.biopha.2020.110500', 'article-title': 'Clinical retrospective study on the efficacy of Qingfei Paidu decoction ' 'combined with Western medicine for COVID‐19 treatment', 'volume': '129', 'author': 'Xin S.', 'year': '2020', 'journal-title': 'Biomedicine & Pharmacotherapy'}, { 'issue': '10', 'key': 'e_1_2_10_77_1', 'doi-asserted-by': 'crossref', 'first-page': '617', 'DOI': '10.1038/s41571-018-0036-9', 'article-title': 'Extracellular vesicles in cancer—Implications for future improvements ' 'in cancer care', 'volume': '15', 'author': 'Xu R.', 'year': '2018', 'journal-title': 'Nature Reviews Clinical Oncology'}, { 'issue': '5', 'key': 'e_1_2_10_78_1', 'doi-asserted-by': 'crossref', 'first-page': '457', 'DOI': '10.1111/irv.12459', 'article-title': 'Curcumin alleviates macrophage activation and lung inflammation induced ' 'by influenza virus infection through inhibiting the NF‐κB signaling ' 'pathway', 'volume': '11', 'author': 'Xu Y.', 'year': '2017', 'journal-title': 'Influenza and Other Respiratory Viruses'}, { 'key': 'e_1_2_10_79_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.lfs.2020.117900', 'article-title': 'The immune system and COVID‐19: Friend or foe?', 'volume': '256', 'author': 'Yazdanpanah F.', 'year': '2020', 'journal-title': 'Life Sciences'}, { 'issue': '11', 'key': 'e_1_2_10_80_1', 'doi-asserted-by': 'crossref', 'first-page': '2911', 'DOI': '10.1002/ptr.6738', 'article-title': 'Potential effects of curcumin in the treatment of COVID‐19 infection', 'volume': '34', 'author': 'Zahedipour F.', 'year': '2020', 'journal-title': 'Phytotherapy Research'}, { 'key': 'e_1_2_10_81_1', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1155/2014/186864', 'article-title': 'A review on antibacterial, antiviral, and antifungal activity of ' 'curcumin', 'volume': '2014', 'author': 'Zorofchian Moghadamtousi S.', 'year': '2014', 'journal-title': 'BioMed Research International'}], 'container-title': 'Phytotherapy Research', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://onlinelibrary.wiley.com/doi/pdf/10.1002/ptr.7844', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 4, 29]], 'date-time': '2023-04-29T07:01:12Z', 'timestamp': 1682751672000}, 'score': 1, 'resource': {'primary': {'URL': 'https://onlinelibrary.wiley.com/doi/10.1002/ptr.7844'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 4, 29]]}, 'references-count': 80, 'alternative-id': ['10.1002/ptr.7844'], 'URL': 'http://dx.doi.org/10.1002/ptr.7844', 'relation': {}, 'ISSN': ['0951-418X', '1099-1573'], 'subject': ['Pharmacology'], 'container-title-short': 'Phytotherapy Research', 'published': {'date-parts': [[2023, 4, 29]]}}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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