Immunoregulatory effects of nanocurcumin in inflammatory milieu: Focus on COVID-19
Fahimeh Lavi Arab, Akram Hoseinzadeh, Fatemeh Sadat Mohammadi, Arezoo Rajabian, Arezoo Faridzadeh, Mahmoud Mahmoudi
Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2024.116131
The use of natural compounds, such as curcumin, to treat infections caused by bacteria, viruses, fungi, parasites, inflammatory diseases, and various types of cancer is an active and dynamic area of research. Curcumin has a long history of use in the food industry, and there is currently a growing interest in its therapeutic applications. Numerous clinical trials have consistently shown that curcumin, a polyphenolic compound, is safe and welltolerated even at high doses. There is no toxicity limit. However, the clinical efficacy of curcumin has been limited by its constraints. However, scientific evidence indicates that the use of adjuvants and carriers, such as nanoparticles, exosomes, micelles, and liposomes, can help overcome this limitation. The properties, functions, and human benefits of using nanocurcumin are well-supported by scientific research. Recent evidence suggests that nanocurcumin may be a beneficial therapeutic modality due to its potential to decrease gene expression and secretion of specific inflammatory biomarkers involved in the cytokinestorm seen in severe COVID-19, as well as increase lymphocyte counts. Nanocurcumin has demonstrated the ability to improve clinical manifestations and modulate immune response and inflammation in various autoinflammatory diseases. Additionally, its efficacy, affordability, and safety make it a promising replacement for residual cancer cells after tumor removal. However, further studies are necessary to evaluate the safety and efficacy of nanocurcumin as a new therapeutic in clinical trials, including appropriate dosage, frequency, and duration.
Authors' contributions Fahimeh Lavi Arab has drafted the work. Akram Hoseinzadeh, Fatemeh Sadat Mohammadi, Arezoo Rajabian, Arezoo Faridzadeh, and Mahmoud Mahmoudi, thoroughly reviewed it. Akram Hoseinzadeh has drawn the Fig. 1 . All authors read and approved the final manuscript.
CRediT authorship contribution statement Faridzadeh Arezoo: Writingoriginal draft. Lavi Arab Fahimeh: Writingreview & editing, Writingoriginal draft. Mohammadi Fatemeh Sadat: Writingreview & editing, Writingoriginal draft.
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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