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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Improvement in SpO2 -46% Improvement Relative Risk Curcumin  Hassaniazad et al.  LATE TREATMENT  DB RCT Is late treatment with curcumin beneficial for COVID-19? Double-blind RCT 40 patients in Iran No significant difference in recovery c19early.org Hassaniazad et al., Phytotherapy Resea.., Sep 2021 Favors curcumin Favors control

A triple-blind, placebo-controlled, randomized clinical trial to evaluate the effect of curcumin-containing nanomicelles on cellular immune responses subtypes and clinical outcome in COVID-19 patients

Hassaniazad et al., Phytotherapy Research, doi:10.1002/ptr.7294
Sep 2021  
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Curcumin for COVID-19
15th treatment shown to reduce risk in February 2021
 
*, now known with p = 0.000000046 from 26 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19early.org
Small RCT with 40 low risk patients in Iran, 20 treated with nano-curcumin, showing no significant difference in outcomes with treatment. Authors note that treatment can improve peripheral blood inflammatory indices and modulate immune response by decreasing Th1 and Th17 responses, increasing T regulatory responses, further reducing IL-17 and IFN-γ, and increasing suppressive cytokines TGF-β and IL-4.
This is the 6th of 20 COVID-19 RCTs for curcumin, which collectively show efficacy with p=0.0000093.
This is the 9th of 26 COVID-19 controlled studies for curcumin, which collectively show efficacy with p=0.000000046 (1 in 22 million).
relative improvement in SpO2, 45.7% worse, RR 1.46, p = 0.90, treatment 20, control 20.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hassaniazad et al., 19 Sep 2021, Double Blind Randomized Controlled Trial, placebo-controlled, Iran, peer-reviewed, 12 authors.
This PaperCurcuminAll
A triple‐blind, placebo‐controlled, randomized clinical trial to evaluate the effect of curcumin‐containing nanomicelles on cellular immune responses subtypes and clinical outcome inCOVID‐19 patients
Mehdi Hassaniazad, Ebrahim Eftekhar, Behnaz Rahnama Inchehsablagh, Hossein Kamali, Abdolali Tousi, Mahmoud Reza Jaafari, Milad Rafat, Mohammad Fathalipour, Sara Nikoofal‐sahlabadi, Hamed Gouklani, Hesam Alizade, Molecular Medicine Amin Reza Nikpoor
Phytotherapy Research, doi:10.1002/ptr.7294
Iran (grant no. 990126) is acknowledged. The Exir Nano Sina company had no role in funding or dedication of SinaCurcumin and placebo capsules, data collection, analysis, and interpretation of data.
CONFLICT OF INTEREST Prof. Mahmoud Reza Jaafari, one of the co-authors, founded Exir Nano Sina Company, a Nano pharmaceutical company. The other coauthors declare no conflict of interest.
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Late treatment
is less effective
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