Therapeutic potential of curcumin in ARDS and COVID‐19
et al., Clinical and Experimental Pharmacology and Physiology, doi:10.1111/1440-1681.13744, Jan 2023
Curcumin for COVID-19
No treatment is 100% effective.
Protocols combine treatments.
Review of the therapeutic potential of curcumin, specifically cyclodextrin-complexed curcumin (CDC), for treating ARDS and COVID-19.
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Suresh et al., 10 Jan 2023, peer-reviewed, 5 authors.
Contact: madathil@umich.edu.
Abstract: DOI: 10.1111/1440-1681.13744
REVIEW
Therapeutic potential of curcumin in ARDS and COVID-19
Madathilparambil V. Suresh | Sairah Francis | Sinan Aktay | Georgia Kralovich | Krishnan Raghavendran
Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
Correspondence
Suresh Madathilparambil, Department of Surgery, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, Michigan, 48109, USA.
Email: madathil@umich.edu
Funding information
National Institutes of Health, Grant/Award Number: HL102013
1 | I NTRODUCTION
Curcumin is a yellow compound produced by plants of the Curcuma longa (turmeric) species. 1 It is the principal curcuminoid of Curcuma longa , a member of the ginger family, Zingiberaceae. 2,3 It is sold as an herbal supplement, cosmetic ingredient, food flavouring and colouring. It has various medicinal preparations common in Ayurveda and Chinese medicine. The medicinal properties of curcumin have been known for thousands of years; however, the exact mechanism(s) of action and bioactive components, many of which have yet to be determined, have only recently been investigated. 2 -4 Curcuminoids have been approved by the United States Food and Drug Administration (FDA) 2 and good tolerability and safety profiles have been shown by clinical trials. 3,5 According to the National Center for Complementary and Integrative Health, turmeric is generally safe, but consuming it in high doses or for extended periods may upset your stomach.
Sairah Francis and Sinan Aktay contributed equally to this article.
Abstract
Curcumin is a safe, non-toxic, readily available and naturally occurring compound, an active constituent of Curcuma longa (turmeric). Curcumin could potentially treat diseases, but faces poor physicochemical and pharmacological characteristics. To overcome these limitations, we developed a stable, water-soluble formulation of curcumin called cyclodextrin-complexed curcumin (CDC). We have previously shown that direct delivery of CDC to the lung following lipopolysaccharides exposure reduces acute lung injury (ALI) and effectively reduces lung injury, inflammation and mortality in mice following Klebsiella pneumoniae . Recently, we found that administration of CDC led to a significant reduction in angiotensin-converting enzyme 2 and signal transducer and activator of transcription 3 expression in gene and protein levels following pneumonia, indicating its potential in treating coronavirus disease 2019 (COVID-19). In this review, we consider the clinical features of ALI and acute respiratory distress syndrome (ARDS) and the role of curcumin in modulating the pathogenesis of bacterial/viral-induced ARDS and COVID-19.
KEYWORDS
ALI, ARDS, COVID-19, curcumin, NFκ B, pneumonia
Gupta et al 2 reported the safety of curcumin at doses as high as 12 g/day over 3 months in humans.
Curcumin, a polyphenol, has been shown to target multiple signalling molecules while also demonstrating activity at the cellular level, which is most likely implicated in its numerous health benefits. 2,3,6 It has been shown to aid in metabolic syndromes, 7 pain 8 and inflammatory conditions. 9,10 The diverse effects of curcumin result from its action on a wide range of cellular targets, including transcription factors, inflammatory cytokines, growth factors, apoptotic proteins and more. 11,12 With so many varied biological targets, curcumin elicits numerous pleiotropic effects, and this renders it therapeutically advantageous because..
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"abstract": "<jats:title>Abstract</jats:title><jats:p>Curcumin is a safe, non‐toxic, readily available and naturally occurring compound, an active constituent of <jats:italic>Curcuma longa</jats:italic> (turmeric). Curcumin could potentially treat diseases, but faces poor physicochemical and pharmacological characteristics. To overcome these limitations, we developed a stable, water‐soluble formulation of curcumin called cyclodextrin‐complexed curcumin (CDC). We have previously shown that direct delivery of CDC to the lung following lipopolysaccharides exposure reduces acute lung injury (ALI) and effectively reduces lung injury, inflammation and mortality in mice following <jats:italic>Klebsiella pneumoniae</jats:italic>. Recently, we found that administration of CDC led to a significant reduction in angiotensin‐converting enzyme 2 and signal transducer and activator of transcription 3 expression in gene and protein levels following pneumonia, indicating its potential in treating coronavirus disease 2019 (COVID‐19). In this review, we consider the clinical features of ALI and acute respiratory distress syndrome (ARDS) and the role of curcumin in modulating the pathogenesis of bacterial/viral‐induced ARDS and COVID‐19.</jats:p>",
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