HuMax-IL8: meta-analysis of COVID-19 studies

All studies Mortality ICU Serious outcomes RCTs RCT mortality All outcomes

Outcome (studies)

Improvement

Relative risk · 95% CI

All studies (1)−6%

Mortality (1)−6%

ICU admission (1)−100%

RCTs (1)−6%

Late (1)−6%

00.511.5+

← HuMax-IL8
reduces riskIncreased
risk →

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c19early.org

October 2026

HuMax-IL8 COVID-19 studies

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Stein (RCT)−6%1.06 · 0.46–2.47death11/295/14

Late treatment−6%1.06 · 0.46–2.4711/295/146% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.9

All studies−6%1.06 · 0.46–2.4711/295/146% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.900.511.52+

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← HuMax-IL8
reduces riskHuMax-IL8
increases risk →

c19early.org

October 2026

HuMax-IL8 COVID-19 mortality results

StudyImprovementRR · 95% CITreatmentControlRelative Risk

Stein (RCT)−6%1.06 · 0.46–2.4711/295/14

Late treatment−6%1.06 · 0.46–2.4711/295/146% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.9

All studies−6%1.06 · 0.46–2.4711/295/146% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.900.511.52+

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← HuMax-IL8
reduces riskHuMax-IL8
increases risk →

c19early.org

October 2026

HuMax-IL8 COVID-19 ICU results

StudyImprovementRR · 95% CITreatmentControlRelative Risk

Stein (RCT)−100%2.00 · 0.34–11.629/181/4

Late treatment−100%2.00 · 0.34–11.629/181/4100% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.45

All studies−100%2.00 · 0.34–11.629/181/4100% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.4500.511.52+

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← HuMax-IL8
reduces riskHuMax-IL8
increases risk →

c19early.org

October 2026

HuMax-IL8 COVID-19 serious outcomes

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Stein (RCT)−6%1.06 · 0.46–2.47death11/295/14

Late treatment−6%1.06 · 0.46–2.4711/295/146% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.9

All studies−6%1.06 · 0.46–2.4711/295/146% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.900.511.52+

Rotate screen for more detailsIncrease width for more details

← HuMax-IL8
reduces riskHuMax-IL8
increases risk →

c19early.org

October 2026

HuMax-IL8 COVID-19 Randomized Controlled Trials

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Stein (RCT)−6%1.06 · 0.46–2.47death11/295/14

Late treatment−6%1.06 · 0.46–2.4711/295/146% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.9

All studies−6%1.06 · 0.46–2.4711/295/146% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.900.511.52+

Rotate screen for more detailsIncrease width for more details

← HuMax-IL8
reduces riskHuMax-IL8
increases risk →

c19early.org

October 2026

HuMax-IL8 COVID-19 RCT mortality results

StudyImprovementRR · 95% CITreatmentControlRelative Risk

Stein (RCT)−6%1.06 · 0.46–2.4711/295/14

Late treatment−6%1.06 · 0.46–2.4711/295/146% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.9

All studies−6%1.06 · 0.46–2.4711/295/146% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.900.511.52+

Rotate screen for more detailsIncrease width for more details

← HuMax-IL8
reduces riskHuMax-IL8
increases risk →

c19early.org

October 2026

HuMax-IL8 COVID-19 outcomes

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Stein (RCT)−6%1.06 · 0.46–2.47death11/295/14 Stein (RCT)3%0.97 · 0.35–2.67death8/294/14 Stein (RCT)−100%2.00 · 0.34–11.62ICU9/181/4 Stein (RCT)−107%2.07 · 0.92–4.65no improv.29 (n)14 (n)

00.511.52+

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← HuMax-IL8
reduces riskHuMax-IL8
increases risk →