Emvododstat: meta-analysis of COVID-19 studies

All studies   Mortality   Ventilation   RCTs   RCT mortality   All outcomes  
0 0.5 1 1.5+ All studies -132% 1 187 Improvement, Studies, Patients Relative Risk Mortality -132% 1 187 Ventilation -47% 1 189 RCTs -132% 1 187 Late -132% 1 187 Emvododstat for COVID-19 c19early.org December 2025 Favorsemvododstat Favorscontrol
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ FITE19 Ngumah (DB RCT) -132% 2.32 [0.74-7.28] death 9/92 4/95 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.15 Late treatment -132% 2.32 [0.74-7.28] 9/92 4/95 132% higher risk All studies -132% 2.32 [0.74-7.28] 9/92 4/95 132% higher risk 1 emvododstat COVID-19 study c19early.org December 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.15 Effect extraction pre-specified(most serious outcome) Favors emvododstat Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ FITE19 Ngumah (DB RCT) -132% 2.32 [0.74-7.28] 9/92 4/95 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.15 Late treatment -132% 2.32 [0.74-7.28] 9/92 4/95 132% higher risk All studies -132% 2.32 [0.74-7.28] 9/92 4/95 132% higher risk 1 emvododstat COVID-19 mortality result c19early.org December 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.15 Favors emvododstat Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ FITE19 Ngumah (DB RCT) -47% 1.47 [0.72-3.00] 16/94 11/95 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.29 Late treatment -47% 1.47 [0.72-3.00] 16/94 11/95 47% higher risk All studies -47% 1.47 [0.72-3.00] 16/94 11/95 47% higher risk 1 emvododstat COVID-19 mechanical ventilation result c19early.org December 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.29 Favors emvododstat Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ FITE19 Ngumah (DB RCT) -132% 2.32 [0.74-7.28] death 9/92 4/95 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.15 Late treatment -132% 2.32 [0.74-7.28] 9/92 4/95 132% higher risk All studies -132% 2.32 [0.74-7.28] 9/92 4/95 132% higher risk 1 emvododstat COVID-19 Randomized Controlled Trial c19early.org December 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.15 Effect extraction pre-specified(most serious outcome) Favors emvododstat Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ FITE19 Ngumah (DB RCT) -132% 2.32 [0.74-7.28] 9/92 4/95 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.15 Late treatment -132% 2.32 [0.74-7.28] 9/92 4/95 132% higher risk All studies -132% 2.32 [0.74-7.28] 9/92 4/95 132% higher risk 1 emvododstat COVID-19 RCT mortality result c19early.org December 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.15 Favors emvododstat Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ FITE19 Ngumah (DB RCT) -132% 2.32 [0.74-7.28] death 9/92 4/95 Improvement, RR [CI] Treatment Control FITE19 Ngumah (DB RCT) -55% 1.55 [0.45-5.31] death 6/92 4/95 FITE19 Ngumah (DB RCT) -47% 1.47 [0.72-3.00] ventilation 16/94 11/95 Emvododstat COVID-19 outcomes c19early.org December 2025 Favors emvododstat Favors control