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Outcomes in COVID-19 apremilast studies

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All studies   Mortality   Serious outcomes   Recovery   RCTs   RCT mortality   All outcomes  
0 0.5 1 1.5+ All studies -1% 1 384 Improvement, Studies, Patients Relative Risk Mortality -1% 1 384 RCTs -1% 1 384 Late -1% 1 384 Apremilast for COVID-19 c19early.org October 2024 Favorsapremilast Favorscontrol
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ COMMUNITY Amgen (DB RCT) -1% 1.01 [0.65-1.56] death 34/194 33/190 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.97 Late treatment -1% 1.01 [0.65-1.56] 34/194 33/190 1% higher risk All studies -1% 1.01 [0.65-1.56] 34/194 33/190 1% higher risk 1 apremilast COVID-19 study c19early.org October 2024 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.97 Effect extraction pre-specified(most serious outcome) Favors apremilast Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ COMMUNITY Amgen (DB RCT) -1% 1.01 [0.65-1.56] 34/194 33/190 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.97 Late treatment -1% 1.01 [0.65-1.56] 34/194 33/190 1% higher risk All studies -1% 1.01 [0.65-1.56] 34/194 33/190 1% higher risk 1 apremilast COVID-19 mortality result c19early.org October 2024 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.97 Favors apremilast Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ COMMUNITY Amgen (DB RCT) -1% 1.01 [0.65-1.56] death 34/194 33/190 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.97 Late treatment -1% 1.01 [0.65-1.56] 34/194 33/190 1% higher risk All studies -1% 1.01 [0.65-1.56] 34/194 33/190 1% higher risk 1 apremilast COVID-19 serious outcome c19early.org October 2024 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.97 Effect extraction pre-specified(most serious outcome) Favors apremilast Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ COMMUNITY Amgen (DB RCT) -11% 1.11 [0.78-1.58] no disch. 50/194 44/190 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.56 Late treatment -11% 1.11 [0.78-1.58] 50/194 44/190 11% higher risk All studies -11% 1.11 [0.78-1.58] 50/194 44/190 11% higher risk 1 apremilast COVID-19 recovery result c19early.org October 2024 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.56 Favors apremilast Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ COMMUNITY Amgen (DB RCT) -1% 1.01 [0.65-1.56] death 34/194 33/190 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.97 Late treatment -1% 1.01 [0.65-1.56] 34/194 33/190 1% higher risk All studies -1% 1.01 [0.65-1.56] 34/194 33/190 1% higher risk 1 apremilast COVID-19 Randomized Controlled Trials c19early.org October 2024 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.97 Effect extraction pre-specified(most serious outcome) Favors apremilast Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ COMMUNITY Amgen (DB RCT) -1% 1.01 [0.65-1.56] 34/194 33/190 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.97 Late treatment -1% 1.01 [0.65-1.56] 34/194 33/190 1% higher risk All studies -1% 1.01 [0.65-1.56] 34/194 33/190 1% higher risk 1 apremilast COVID-19 RCT mortality result c19early.org October 2024 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.97 Favors apremilast Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ COMMUNITY Amgen (DB RCT) -1% 1.01 [0.65-1.56] death 34/194 33/190 Improvement, RR [CI] Treatment Control COMMUNITY Amgen (DB RCT) -8% 1.08 [0.77-1.51] no improv. 53/194 48/190 COMMUNITY Amgen (DB RCT) -11% 1.11 [0.78-1.58] no disch. 50/194 44/190 COMMUNITY Amgen (DB RCT) -11% 1.11 [0.81-1.50] no recov. 61/194 54/190 Apremilast COVID-19 outcomes c19early.org October 2024 Favors apremilast Favors control
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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