AZD5156: meta-analysis of COVID-19 studies

0 0.5 1 1.5+ All studies -139% 1 57 Improvement, Studies, Patients Relative Risk Mortality -139% 1 57 RCTs -139% 1 57 Prophylaxis -139% 1 57 AZD5156 for COVID-19 c19early.org June 2026 FavorsAZD5156 Favorscontrol
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ SUPERNOVA Haidar (DB RCT) -139% 2.39 [0.10-55.8] death 1/41 0/16 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.6 Prophylaxis -139% 2.39 [0.10-55.8] 1/41 0/16 139% higher risk All studies -139% 2.39 [0.10-55.8] 1/41 0/16 139% higher risk 1 AZD5156 COVID-19 study c19early.org June 2026 Tau​2 = 0.00, I​2 = 0.0%, p = 0.6 Effect extraction pre-specified(most serious outcome) Favors AZD5156 Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ SUPERNOVA Haidar (DB RCT) -139% 2.39 [0.10-55.8] 1/41 0/16 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.6 Prophylaxis -139% 2.39 [0.10-55.8] 1/41 0/16 139% higher risk All studies -139% 2.39 [0.10-55.8] 1/41 0/16 139% higher risk 1 AZD5156 COVID-19 mortality result c19early.org June 2026 Tau​2 = 0.00, I​2 = 0.0%, p = 0.6 Favors AZD5156 Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ SUPERNOVA Haidar (DB RCT) -139% 2.39 [0.10-55.8] death 1/41 0/16 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.6 Prophylaxis -139% 2.39 [0.10-55.8] 1/41 0/16 139% higher risk All studies -139% 2.39 [0.10-55.8] 1/41 0/16 139% higher risk 1 AZD5156 COVID-19 Randomized Controlled Trial c19early.org June 2026 Tau​2 = 0.00, I​2 = 0.0%, p = 0.6 Effect extraction pre-specified(most serious outcome) Favors AZD5156 Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ SUPERNOVA Haidar (DB RCT) -139% 2.39 [0.10-55.8] 1/41 0/16 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.6 Prophylaxis -139% 2.39 [0.10-55.8] 1/41 0/16 139% higher risk All studies -139% 2.39 [0.10-55.8] 1/41 0/16 139% higher risk 1 AZD5156 COVID-19 RCT mortality result c19early.org June 2026 Tau​2 = 0.00, I​2 = 0.0%, p = 0.6 Favors AZD5156 Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ SUPERNOVA Haidar (DB RCT) -139% 2.39 [0.10-55.8] death 1/41 0/16 Improvement, RR [CI] Treatment Control AZD5156 COVID-19 outcomes c19early.org June 2026 Favors AZD5156 Favors control