Outcomes in COVID-19 BI 764198 studies

0 0.5 1 1.5+ All studies -117% 1 129 Improvement, Studies, Patients Relative Risk Mortality -117% 1 129 RCTs -117% 1 129 Late -117% 1 129 BI 764198 for COVID-19 c19early.org December 2025 FavorsBI 764198 Favorscontrol
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Ware (DB RCT) -117% 2.17 [0.80-5.88] death 11/65 5/64 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.13 Late treatment -117% 2.17 [0.80-5.88] 11/65 5/64 117% higher risk All studies -117% 2.17 [0.80-5.88] 11/65 5/64 117% higher risk 1 BI 764198 COVID-19 study c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.13 Effect extraction pre-specified(most serious outcome) Favors BI 764198 Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Ware (DB RCT) -117% 2.17 [0.80-5.88] 11/65 5/64 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.13 Late treatment -117% 2.17 [0.80-5.88] 11/65 5/64 117% higher risk All studies -117% 2.17 [0.80-5.88] 11/65 5/64 117% higher risk 1 BI 764198 COVID-19 mortality result c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.13 Favors BI 764198 Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Ware (DB RCT) -117% 2.17 [0.80-5.88] death 11/65 5/64 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.13 Late treatment -117% 2.17 [0.80-5.88] 11/65 5/64 117% higher risk All studies -117% 2.17 [0.80-5.88] 11/65 5/64 117% higher risk 1 BI 764198 COVID-19 serious outcome c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.13 Effect extraction pre-specified(most serious outcome) Favors BI 764198 Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Ware (DB RCT) -42% 1.42 [0.65-3.09] no recov. 13/65 9/64 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.38 Late treatment -42% 1.42 [0.65-3.09] 13/65 9/64 42% higher risk All studies -42% 1.42 [0.65-3.09] 13/65 9/64 42% higher risk 1 BI 764198 COVID-19 recovery result c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.38 Favors BI 764198 Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Ware (DB RCT) -117% 2.17 [0.80-5.88] death 11/65 5/64 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.13 Late treatment -117% 2.17 [0.80-5.88] 11/65 5/64 117% higher risk All studies -117% 2.17 [0.80-5.88] 11/65 5/64 117% higher risk 1 BI 764198 COVID-19 Randomized Controlled Trial c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.13 Effect extraction pre-specified(most serious outcome) Favors BI 764198 Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Ware (DB RCT) -117% 2.17 [0.80-5.88] 11/65 5/64 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.13 Late treatment -117% 2.17 [0.80-5.88] 11/65 5/64 117% higher risk All studies -117% 2.17 [0.80-5.88] 11/65 5/64 117% higher risk 1 BI 764198 COVID-19 RCT mortality result c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.13 Favors BI 764198 Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Ware (DB RCT) -117% 2.17 [0.80-5.88] death 11/65 5/64 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.13 Late treatment -117% 2.17 [0.80-5.88] 11/65 5/64 117% higher risk All studies -117% 2.17 [0.80-5.88] 11/65 5/64 117% higher risk 1 BI 764198 COVID-19 peer reviewed studies c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.13 Effect extraction pre-specified(most serious outcome) Favors BI 764198 Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Ware (DB RCT) -117% 2.17 [0.80-5.88] death 11/65 5/64 Improvement, RR [CI] Treatment Control Ware (DB RCT) -97% 1.97 [0.71-5.44] death 10/65 5/64 Ware (DB RCT) -58% 1.58 [0.54-4.56] death 8/65 5/64 Ware (DB RCT) -294% 3.94 [0.45-34.3] death 4/65 1/64 Ware (DB RCT) -12% 1.12 [0.61-2.04] progression 17/65 15/64 Ware (DB RCT) -42% 1.42 [0.65-3.09] no recov. 13/65 9/64 BI 764198 COVID-19 outcomes c19early.org December 2025 Favors BI 764198 Favors control