Posaconazole: meta-analysis of COVID-19 studies

All studies   Mortality   Peer-reviewed   All outcomes  
0 0.5 1 1.5+ All studies -131% 1 249 Improvement, Studies, Patients Relative Risk Mortality -131% 1 249 Prophylaxis -131% 1 249 Posaconazole for COVID-19 c19early.org December 2025 Favorsposaconazole Favorscontrol
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ POSACOVID Prattes -131% 2.31 [1.78-3.00] death 60/83 52/166 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p < 0.0001 Prophylaxis -131% 2.31 [1.78-3.00] 60/83 52/166 131% higher risk All studies -131% 2.31 [1.78-3.00] 60/83 52/166 131% higher risk 1 posaconazole COVID-19 study c19early.org December 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p < 0.0001 Effect extraction pre-specified(most serious outcome) Favors posaconazole Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ POSACOVID Prattes -131% 2.31 [1.78-3.00] 60/83 52/166 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p < 0.0001 Prophylaxis -131% 2.31 [1.78-3.00] 60/83 52/166 131% higher risk All studies -131% 2.31 [1.78-3.00] 60/83 52/166 131% higher risk 1 posaconazole COVID-19 mortality result c19early.org December 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p < 0.0001 Favors posaconazole Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ POSACOVID Prattes -131% 2.31 [1.78-3.00] death 60/83 52/166 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p < 0.0001 Prophylaxis -131% 2.31 [1.78-3.00] 60/83 52/166 131% higher risk All studies -131% 2.31 [1.78-3.00] 60/83 52/166 131% higher risk 1 posaconazole COVID-19 peer reviewed studies c19early.org December 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p < 0.0001 Effect extraction pre-specified(most serious outcome) Favors posaconazole Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ POSACOVID Prattes -131% 2.31 [1.78-3.00] death 60/83 52/166 Improvement, RR [CI] Treatment Control POSACOVID Prattes 54% 0.46 [0.08-2.82] misc. 83 (n) 83 (n) POSACOVID Prattes 80% 0.20 [0.06-0.65] misc. 83 (n) 83 (n) POSACOVID Prattes -25% 1.25 [0.26-5.88] misc. 83 (n) 83 (n) Posaconazole COVID-19 outcomes c19early.org December 2025 Favors posaconazole Favors control