Diacerein: meta-analysis of COVID-19 studies

0 0.5 1 1.5+ All studies -10% 1 14 Improvement, Studies, Patients Relative Risk Hospitalization -10% 1 14 RCTs -10% 1 14 Late -10% 1 14 Diacerein for COVID-19 c19early.org December 2025 Favorsdiacerein Favorscontrol
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Carmo (DB RCT) -10% 1.10 [0.57-2.11] hosp. time 7 (n) 7 (n) Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.79 Late treatment -10% 1.10 [0.57-2.11] 7 (n) 7 (n) 10% higher risk All studies -10% 1.10 [0.57-2.11] 7 (n) 7 (n) 10% higher risk 1 diacerein COVID-19 study c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.79 Effect extraction pre-specified(most serious outcome) Favors diacerein Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Carmo (DB RCT) -10% 1.10 [0.57-2.11] hosp. time 7 (n) 7 (n) Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.79 Late treatment -10% 1.10 [0.57-2.11] 7 (n) 7 (n) 10% higher risk All studies -10% 1.10 [0.57-2.11] 7 (n) 7 (n) 10% higher risk 1 diacerein COVID-19 hospitalization result c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.79 Favors diacerein Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Carmo (DB RCT) -10% 1.10 [0.57-2.11] hosp. time 7 (n) 7 (n) Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.79 Late treatment -10% 1.10 [0.57-2.11] 7 (n) 7 (n) 10% higher risk All studies -10% 1.10 [0.57-2.11] 7 (n) 7 (n) 10% higher risk 1 diacerein COVID-19 Randomized Controlled Trial c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.79 Effect extraction pre-specified(most serious outcome) Favors diacerein Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Carmo (DB RCT) -10% 1.10 [0.57-2.11] hosp. time 7 (n) 7 (n) Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.79 Late treatment -10% 1.10 [0.57-2.11] 7 (n) 7 (n) 10% higher risk All studies -10% 1.10 [0.57-2.11] 7 (n) 7 (n) 10% higher risk 1 diacerein COVID-19 peer reviewed studies c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.79 Effect extraction pre-specified(most serious outcome) Favors diacerein Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Carmo (DB RCT) -10% 1.10 [0.57-2.11] hosp. time 7 (n) 7 (n) Improvement, RR [CI] Treatment Control Diacerein COVID-19 outcomes c19early.org December 2025 Favors diacerein Favors control