Amiodarone: meta-analysis of COVID-19 studies

All studies Mortality Ventilation Serious outcomes Recovery RCTs RCT mortality Peer-reviewed All outcomes

Outcome (studies)

Improvement

Relative risk · 95% CI

All studies (1)−103%

Mortality (1)−103%

Ventilation (1)−52%

RCTs (1)−103%

Late (1)−103%

00.511.5+

← Amiodarone
reduces riskIncreased
risk →

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c19early.org

October 2026

Amiodarone COVID-19 studies

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Navarese (RCT)−103%2.03 · 0.53–7.80death6/713/72RECOVERY-SIRIO

Late treatment−103%2.03 · 0.53–7.806/713/72103% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.31

All studies−103%2.03 · 0.53–7.806/713/72103% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.3100.511.52+

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← Amiodarone
reduces riskAmiodarone
increases risk →

c19early.org

October 2026

Amiodarone COVID-19 mortality results

StudyImprovementRR · 95% CITreatmentControlRelative Risk

Navarese (RCT)−103%2.03 · 0.53–7.806/713/72RECOVERY-SIRIO

Late treatment−103%2.03 · 0.53–7.806/713/72103% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.31

All studies−103%2.03 · 0.53–7.806/713/72103% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.3100.511.52+

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← Amiodarone
reduces riskAmiodarone
increases risk →

c19early.org

October 2026

Amiodarone COVID-19 mechanical ventilation results

StudyImprovementRR · 95% CITreatmentControlRelative Risk

Navarese (RCT)−52%1.52 · 0.57–4.059/716/72RECOVERY-SIRIO

Late treatment−52%1.52 · 0.57–4.059/716/7252% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.41

All studies−52%1.52 · 0.57–4.059/716/7252% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.4100.511.52+

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← Amiodarone
reduces riskAmiodarone
increases risk →

c19early.org

October 2026

Amiodarone COVID-19 serious outcomes

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Navarese (RCT)−103%2.03 · 0.53–7.80death6/713/72RECOVERY-SIRIO

Late treatment−103%2.03 · 0.53–7.806/713/72103% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.31

All studies−103%2.03 · 0.53–7.806/713/72103% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.3100.511.52+

Rotate screen for more detailsIncrease width for more details

← Amiodarone
reduces riskAmiodarone
increases risk →

c19early.org

October 2026

Amiodarone COVID-19 recovery results

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Navarese (RCT)−30%1.30 · 0.88–1.92no recov.71 (n)72 (n)RECOVERY-SIRIO

Late treatment−30%1.30 · 0.88–1.9271 (n)72 (n)30% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.19

All studies−30%1.30 · 0.88–1.9271 (n)72 (n)30% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.1900.511.52+

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← Amiodarone
reduces riskAmiodarone
increases risk →

c19early.org

October 2026

Amiodarone COVID-19 Randomized Controlled Trials

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Navarese (RCT)−103%2.03 · 0.53–7.80death6/713/72RECOVERY-SIRIO

Late treatment−103%2.03 · 0.53–7.806/713/72103% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.31

All studies−103%2.03 · 0.53–7.806/713/72103% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.3100.511.52+

Rotate screen for more detailsIncrease width for more details

← Amiodarone
reduces riskAmiodarone
increases risk →

c19early.org

October 2026

Amiodarone COVID-19 RCT mortality results

StudyImprovementRR · 95% CITreatmentControlRelative Risk

Navarese (RCT)−103%2.03 · 0.53–7.806/713/72RECOVERY-SIRIO

Late treatment−103%2.03 · 0.53–7.806/713/72103% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.31

All studies−103%2.03 · 0.53–7.806/713/72103% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.3100.511.52+

Rotate screen for more detailsIncrease width for more details

← Amiodarone
reduces riskAmiodarone
increases risk →

c19early.org

October 2026

Amiodarone COVID-19 peer reviewed studies

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Navarese (RCT)−103%2.03 · 0.53–7.80death6/713/72RECOVERY-SIRIO

Late treatment−103%2.03 · 0.53–7.806/713/72103% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.31

All studies−103%2.03 · 0.53–7.806/713/72103% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.3100.511.52+

Rotate screen for more detailsIncrease width for more details

← Amiodarone
reduces riskAmiodarone
increases risk →

c19early.org

October 2026

Amiodarone COVID-19 outcomes

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Navarese (RCT)−103%2.03 · 0.53–7.80death6/713/72RECOVERY-SIRIO Navarese (RCT)−52%1.52 · 0.57–4.05ventilation9/716/72RECOVERY-SIRIO Navarese (RCT)−30%1.30 · 0.88–1.92no recov.71 (n)72 (n)RECOVERY-SIRIO

00.511.52+

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← Amiodarone
reduces riskAmiodarone
increases risk →