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$0 $1,000 $2,000+ -25+% 0% 25% 50% Treatment cost (US$) Efficacy vs. cost for COVID-19 treatments +58 more high-profit drugs PPIs -46% BMS mAbs -36% >$2,000 Darunavir -34% Acetaminophen -28% Cenicriviroc -28% >$2,000 Lufotrelvir >$2,000 Dexamethasone Losartan Sargramostim >$2,000 Cannabidiol Lopinavir/ritonavir Ravulizumab >$2,000 Remdesivir $3,120 Conv. Plasma $5,000 Sarilumab >$2,000 Ibuprofen Masks Molnupiravir mutagenic/teratogenic Aspirin Tocilizumab Favipiravir Paxlovid Ratutrelvir Famotidine Vitamin C Sotrovimab $2,100 Colchicine TMPRSS2 i.. NAC Amubarvimab/r.. Vilobelimab $6,350 Ensitrelvir Azvudine Budesonide Probiotics HCQ Zinc Antiandro.. Sleep Metformin Vitamin A Melatonin Tixagevimab/c.. Bebtelovimab Nitric Oxide Quercetin H1RAs CPC Vitamin D H. Peroxide Exercise Fluvox. Sunlight Curcumin N. Sativa NaHCO₃ Casirivimab/i.. $2,100 Bamlanivimab/e.. Ensovibep >$2,000 PVP-I pH+ Diet Regdanvimab $2,100 Thermotherapy Ivermectin Lifestyle / free No prescription Prescription required High-cost Lowerrisk Higherrisk c19early.org June 2026 USA official early treatments COVID-19 involves the interplay of 500+ host/viral proteins/factors, modulated by many treatments. 0.5% of 11,000+proposed treatments show efficacy with ≥3 studies.Protocols combine treatments, none are 100% effective.c19early analyzes over 6,600 studies for 223 treatments.
ALG-097558 is an orally bioavailable small-molecule antiviral drug that functions as a pan-coronavirus 3CLpro inhibitor.
May 18
 Hull et al., NCT06945276 A Phase 1 Study to Evaluate Relative Bioavailability and Food Effect of an ALG-097558 Tablet Formulation and the Drug-Drug Interaction Potential of ALG-097558 and Its Metabolite ALG-097730 in Healthy Volunteers
Phase 1 randomized study sponsored by NIAID, enrolling 51 healthy volunteers to characterize the bioavailability, food effect, and drug-drug interaction profile of ALG-097558. Co-administration with itraconazole (a strong CYP3A4/P-gp inhi..