Estetrol: meta-analysis of COVID-19 studies

All studies   Mortality   Serious outcomes   Recovery   RCTs   RCT mortality   Peer-reviewed   All outcomes  
Meta-analysis1 study · 171 patientsc19early.org

Estetrol for COVID-19

Serious outcome risk
Estetrol
Control
Outcome (studies)
Improvement
Relative risk · 95% CI
All studies (1)−102%
Mortality (1)−102%
RCTs (1)−102%
Late (1)−102%
00.511.5+
← Estetrol
reduces riskIncreased
risk →
c19early.org
October 2026

Estetrol COVID-19 studies

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk
Foidart (DB RCT)−102%2.02 · 0.52–7.83death6/853/86
Late treatment−102%2.02 · 0.52–7.836/853/86102% higher risk
Tau² = 0.00, I² = 0.0%, p = 0.31
All studies−102%2.02 · 0.52–7.836/853/86102% higher risk
Tau² = 0.00, I² = 0.0%, p = 0.3100.511.52+
Rotate screen for more detailsIncrease width for more details
← Estetrol
reduces riskEstetrol
increases risk →
c19early.org
October 2026

Estetrol COVID-19 mortality results

StudyImprovementRR · 95% CITreatmentControlRelative Risk
Foidart (DB RCT)−102%2.02 · 0.52–7.836/853/86
Late treatment−102%2.02 · 0.52–7.836/853/86102% higher risk
Tau² = 0.00, I² = 0.0%, p = 0.31
All studies−102%2.02 · 0.52–7.836/853/86102% higher risk
Tau² = 0.00, I² = 0.0%, p = 0.3100.511.52+
Rotate screen for more detailsIncrease width for more details
← Estetrol
reduces riskEstetrol
increases risk →
c19early.org
October 2026

Estetrol COVID-19 serious outcomes

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk
Foidart (DB RCT)−102%2.02 · 0.52–7.83death6/853/86
Late treatment−102%2.02 · 0.52–7.836/853/86102% higher risk
Tau² = 0.00, I² = 0.0%, p = 0.31
All studies−102%2.02 · 0.52–7.836/853/86102% higher risk
Tau² = 0.00, I² = 0.0%, p = 0.3100.511.52+
Rotate screen for more detailsIncrease width for more details
← Estetrol
reduces riskEstetrol
increases risk →
c19early.org
October 2026

Estetrol COVID-19 recovery results

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk
Foidart (DB RCT)−117%2.17 · 0.93–5.05no recov.15/857/86
Late treatment−117%2.17 · 0.93–5.0515/857/86117% higher risk
Tau² = 0.00, I² = 0.0%, p = 0.072
All studies−117%2.17 · 0.93–5.0515/857/86117% higher risk
Tau² = 0.00, I² = 0.0%, p = 0.07200.511.52+
Rotate screen for more detailsIncrease width for more details
← Estetrol
reduces riskEstetrol
increases risk →
c19early.org
October 2026

Estetrol COVID-19 Randomized Controlled Trials

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk
Foidart (DB RCT)−102%2.02 · 0.52–7.83death6/853/86
Late treatment−102%2.02 · 0.52–7.836/853/86102% higher risk
Tau² = 0.00, I² = 0.0%, p = 0.31
All studies−102%2.02 · 0.52–7.836/853/86102% higher risk
Tau² = 0.00, I² = 0.0%, p = 0.3100.511.52+
Rotate screen for more detailsIncrease width for more details
← Estetrol
reduces riskEstetrol
increases risk →
c19early.org
October 2026

Estetrol COVID-19 RCT mortality results

StudyImprovementRR · 95% CITreatmentControlRelative Risk
Foidart (DB RCT)−102%2.02 · 0.52–7.836/853/86
Late treatment−102%2.02 · 0.52–7.836/853/86102% higher risk
Tau² = 0.00, I² = 0.0%, p = 0.31
All studies−102%2.02 · 0.52–7.836/853/86102% higher risk
Tau² = 0.00, I² = 0.0%, p = 0.3100.511.52+
Rotate screen for more detailsIncrease width for more details
← Estetrol
reduces riskEstetrol
increases risk →
c19early.org
October 2026

Estetrol COVID-19 peer reviewed studies

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk
Foidart (DB RCT)−102%2.02 · 0.52–7.83death6/853/86
Late treatment−102%2.02 · 0.52–7.836/853/86102% higher risk
Tau² = 0.00, I² = 0.0%, p = 0.31
All studies−102%2.02 · 0.52–7.836/853/86102% higher risk
Tau² = 0.00, I² = 0.0%, p = 0.3100.511.52+
Rotate screen for more detailsIncrease width for more details
← Estetrol
reduces riskEstetrol
increases risk →