Outcomes in COVID-19 estetrol studies

All studies   Mortality   Serious outcomes   Recovery   RCTs   RCT mortality   Peer-reviewed   All outcomes  
0 0.5 1 1.5+ All studies -102% 1 171 Improvement, Studies, Patients Relative Risk Mortality -102% 1 171 RCTs -102% 1 171 Late -102% 1 171 Estetrol for COVID-19 c19early.org November 2025 Favorsestetrol Favorscontrol
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Foidart (DB RCT) -102% 2.02 [0.52-7.83] death 6/85 3/86 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.31 Late treatment -102% 2.02 [0.52-7.83] 6/85 3/86 102% higher risk All studies -102% 2.02 [0.52-7.83] 6/85 3/86 102% higher risk 1 estetrol COVID-19 study c19early.org November 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.31 Effect extraction pre-specified(most serious outcome) Favors estetrol Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Foidart (DB RCT) -102% 2.02 [0.52-7.83] 6/85 3/86 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.31 Late treatment -102% 2.02 [0.52-7.83] 6/85 3/86 102% higher risk All studies -102% 2.02 [0.52-7.83] 6/85 3/86 102% higher risk 1 estetrol COVID-19 mortality result c19early.org November 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.31 Favors estetrol Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Foidart (DB RCT) -102% 2.02 [0.52-7.83] death 6/85 3/86 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.31 Late treatment -102% 2.02 [0.52-7.83] 6/85 3/86 102% higher risk All studies -102% 2.02 [0.52-7.83] 6/85 3/86 102% higher risk 1 estetrol COVID-19 serious outcome c19early.org November 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.31 Effect extraction pre-specified(most serious outcome) Favors estetrol Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Foidart (DB RCT) -117% 2.17 [0.93-5.05] no recov. 15/85 7/86 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.072 Late treatment -117% 2.17 [0.93-5.05] 15/85 7/86 117% higher risk All studies -117% 2.17 [0.93-5.05] 15/85 7/86 117% higher risk 1 estetrol COVID-19 recovery result c19early.org November 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.072 Favors estetrol Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Foidart (DB RCT) -102% 2.02 [0.52-7.83] death 6/85 3/86 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.31 Late treatment -102% 2.02 [0.52-7.83] 6/85 3/86 102% higher risk All studies -102% 2.02 [0.52-7.83] 6/85 3/86 102% higher risk 1 estetrol COVID-19 Randomized Controlled Trial c19early.org November 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.31 Effect extraction pre-specified(most serious outcome) Favors estetrol Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Foidart (DB RCT) -102% 2.02 [0.52-7.83] 6/85 3/86 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.31 Late treatment -102% 2.02 [0.52-7.83] 6/85 3/86 102% higher risk All studies -102% 2.02 [0.52-7.83] 6/85 3/86 102% higher risk 1 estetrol COVID-19 RCT mortality result c19early.org November 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.31 Favors estetrol Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Foidart (DB RCT) -102% 2.02 [0.52-7.83] death 6/85 3/86 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.31 Late treatment -102% 2.02 [0.52-7.83] 6/85 3/86 102% higher risk All studies -102% 2.02 [0.52-7.83] 6/85 3/86 102% higher risk 1 estetrol COVID-19 peer reviewed studies c19early.org November 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.31 Effect extraction pre-specified(most serious outcome) Favors estetrol Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Foidart (DB RCT) -102% 2.02 [0.52-7.83] death 6/85 3/86 Improvement, RR [CI] Treatment Control Foidart (DB RCT) -117% 2.17 [0.93-5.05] no recov. 15/85 7/86 Estetrol COVID-19 outcomes c19early.org November 2025 Favors estetrol Favors control