Fenretinide: meta-analysis of COVID-19 studies

0 0.5 1 1.5+ All studies -44% 1 351 Improvement, Studies, Patients Relative Risk Mortality -44% 1 351 RCTs -44% 1 351 Late -44% 1 351 Fenretinide for COVID-19 c19early.org December 2025 Favorsfenretinide Favorscontrol
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ RESOLUTION Houle (DB RCT) -44% 1.44 [0.71-2.93] death 17/174 12/177 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.32 Late treatment -44% 1.44 [0.71-2.93] 17/174 12/177 44% higher risk All studies -44% 1.44 [0.71-2.93] 17/174 12/177 44% higher risk 1 fenretinide COVID-19 study c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.32 Effect extraction pre-specified(most serious outcome) Favors fenretinide Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ RESOLUTION Houle (DB RCT) -44% 1.44 [0.71-2.93] 17/174 12/177 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.32 Late treatment -44% 1.44 [0.71-2.93] 17/174 12/177 44% higher risk All studies -44% 1.44 [0.71-2.93] 17/174 12/177 44% higher risk 1 fenretinide COVID-19 mortality result c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.32 Favors fenretinide Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ RESOLUTION Houle (DB RCT) -44% 1.44 [0.71-2.93] death 17/174 12/177 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.32 Late treatment -44% 1.44 [0.71-2.93] 17/174 12/177 44% higher risk All studies -44% 1.44 [0.71-2.93] 17/174 12/177 44% higher risk 1 fenretinide COVID-19 Randomized Controlled Trial c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.32 Effect extraction pre-specified(most serious outcome) Favors fenretinide Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ RESOLUTION Houle (DB RCT) -44% 1.44 [0.71-2.93] 17/174 12/177 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.32 Late treatment -44% 1.44 [0.71-2.93] 17/174 12/177 44% higher risk All studies -44% 1.44 [0.71-2.93] 17/174 12/177 44% higher risk 1 fenretinide COVID-19 RCT mortality result c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.32 Favors fenretinide Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ RESOLUTION Houle (DB RCT) -44% 1.44 [0.71-2.93] death 17/174 12/177 Improvement, RR [CI] Treatment Control RESOLUTION Houle (DB RCT) -25% 1.25 [0.59-2.64] death 14/117 11/115 RESOLUTION Houle (DB RCT) -226% 3.26 [0.35-30.5] death 3/57 1/62 Fenretinide COVID-19 outcomes c19early.org December 2025 Favors fenretinide Favors control