Ibrutinib: meta-analysis of COVID-19 studies

All studies Mortality Serious outcomes Recovery RCTs RCT mortality Peer-reviewed All outcomes

Outcome (studies)

Improvement

Relative risk · 95% CI

All studies (1)−9%

Mortality (1)−9%

RCTs (1)−9%

Late (1)−9%

00.511.5+

← Ibrutinib
reduces riskIncreased
risk →

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c19early.org

October 2026

Ibrutinib COVID-19 studies (+1 unreported RCT)

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Coutre (DB RCT)−9%1.09 · 0.07–16.41death1/221/24iNSPIRE Woyach (RCT)n/a< NOT REPORTED >10 (total)>4 years late

Late treatment−9%1.09 · 0.07–16.411/221/249% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.95

All studies−9%1.09 · 0.07–16.411/221/249% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.9500.511.52+

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← Ibrutinib
reduces riskIbrutinib
increases risk →

c19early.org

October 2026

Ibrutinib COVID-19 mortality results

StudyImprovementRR · 95% CITreatmentControlRelative Risk

Coutre (DB RCT)−9%1.09 · 0.07–16.411/221/24iNSPIRE

Late treatment−9%1.09 · 0.07–16.411/221/249% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.95

All studies−9%1.09 · 0.07–16.411/221/249% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.9500.511.52+

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← Ibrutinib
reduces riskIbrutinib
increases risk →

c19early.org

October 2026

Ibrutinib COVID-19 serious outcomes

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Coutre (DB RCT)−9%1.09 · 0.07–16.41death1/221/24iNSPIRE

Late treatment−9%1.09 · 0.07–16.411/221/249% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.95

All studies−9%1.09 · 0.07–16.411/221/249% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.9500.511.52+

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← Ibrutinib
reduces riskIbrutinib
increases risk →

c19early.org

October 2026

Ibrutinib COVID-19 recovery results

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Coutre (DB RCT)−9%1.09 · 0.07–16.41no disch.1/221/24iNSPIRE

Late treatment−9%1.09 · 0.07–16.411/221/249% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.95

All studies−9%1.09 · 0.07–16.411/221/249% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.9500.511.52+

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← Ibrutinib
reduces riskIbrutinib
increases risk →

c19early.org

October 2026

Ibrutinib COVID-19 Randomized Controlled Trials

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Coutre (DB RCT)−9%1.09 · 0.07–16.41death1/221/24iNSPIRE Woyach (RCT)n/a< NOT REPORTED >10 (total)>4 years late

Late treatment−9%1.09 · 0.07–16.411/221/249% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.95

All studies−9%1.09 · 0.07–16.411/221/249% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.9500.511.52+

Rotate screen for more detailsIncrease width for more details

← Ibrutinib
reduces riskIbrutinib
increases risk →

c19early.org

October 2026

Ibrutinib COVID-19 RCT mortality results

StudyImprovementRR · 95% CITreatmentControlRelative Risk

Coutre (DB RCT)−9%1.09 · 0.07–16.411/221/24iNSPIRE

Late treatment−9%1.09 · 0.07–16.411/221/249% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.95

All studies−9%1.09 · 0.07–16.411/221/249% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.9500.511.52+

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← Ibrutinib
reduces riskIbrutinib
increases risk →

c19early.org

October 2026

Ibrutinib COVID-19 peer reviewed studies

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Coutre (DB RCT)−9%1.09 · 0.07–16.41death1/221/24iNSPIRE

Late treatment−9%1.09 · 0.07–16.411/221/249% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.95

All studies−9%1.09 · 0.07–16.411/221/249% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.9500.511.52+

Rotate screen for more detailsIncrease width for more details

← Ibrutinib
reduces riskIbrutinib
increases risk →

c19early.org

October 2026

Ibrutinib COVID-19 outcomes

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Coutre (DB RCT)−9%1.09 · 0.07–16.41death1/221/24iNSPIRE Coutre (DB RCT)−209%3.09 · 0.13–72.14death1/220/24iNSPIRE Coutre (DB RCT)−9%1.09 · 0.07–16.41no disch.1/221/24iNSPIRE Coutre (DB RCT)35%0.65 · 0.18–2.42progression3/225/24iNSPIRE

00.511.52+

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← Ibrutinib
reduces riskIbrutinib
increases risk →