Hypochlorous Acid: meta-analysis of COVID-19 studies

All studies   Serious outcomes   Recovery   Cases   Viral clearance   RCTs   Peer-reviewed   All outcomes  
0 0.5 1 1.5+ All studies 50% 3 341 Improvement, Studies, Patients Relative Risk Cases 91% 1 163 Viral clearance 29% 1 49 RCTs 50% 3 341 Prophylaxis 91% 1 163 Early 28% 2 178 Hypochlorous Acid for COVID-19 c19early.org January 2026 Favorshypochlorous acid Favorscontrol
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Delgado-En.. (RCT) 28% 0.72 [0.65-0.79] recovery 35 (n) 104 (n) Improvement, RR [CI] Treatment Control Panatto (RCT) 37% 0.63 [0.12-3.38] progression 2/20 3/19 Tau​2​ = 0.00, I​2​ = 0.0%, p < 0.0001 Early treatment 28% 0.72 [0.65-0.79] 2/55 3/123 28% lower risk Gutiérrez-G.. (RCT) 91% 0.09 [0.01-0.72] symp. case 1/84 10/79 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.022 Prophylaxis 91% 0.09 [0.01-0.72] 1/84 10/79 91% lower risk All studies 50% 0.50 [0.19-1.32] 3/139 13/202 50% lower risk 3 hypochlorous acid COVID-19 studies c19early.org January 2026 Tau​2​ = 0.41, I​2​ = 48.1%, p = 0.16 Effect extraction pre-specified(most serious outcome) Favors hypochlorous acid Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Panatto (RCT) 37% 0.63 [0.12-3.38] progression 2/20 3/19 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.61 Early treatment 37% 0.63 [0.12-3.38] 2/20 3/19 37% lower risk All studies 37% 0.63 [0.12-3.38] 2/20 3/19 37% lower risk 1 hypochlorous acid COVID-19 serious outcome c19early.org January 2026 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.61 Effect extraction pre-specified(most serious outcome) Favors hypochlorous acid Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Delgado-En.. (RCT) 28% 0.72 [0.65-0.79] recovery 35 (n) 104 (n) Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p < 0.0001 Early treatment 28% 0.72 [0.65-0.79] 35 (n) 104 (n) 28% lower risk All studies 28% 0.72 [0.65-0.79] 35 (n) 104 (n) 28% lower risk 1 hypochlorous acid COVID-19 recovery result c19early.org January 2026 Tau​2​ = 0.00, I​2​ = 0.0%, p < 0.0001 Favors hypochlorous acid Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Gutiérrez-G.. (RCT) 91% 0.09 [0.01-0.72] symp. case 1/84 10/79 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.022 Prophylaxis 91% 0.09 [0.01-0.72] 1/84 10/79 91% lower risk All studies 91% 0.09 [0.01-0.72] 1/84 10/79 91% lower risk 1 hypochlorous acid COVID-19 case result c19early.org January 2026 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.022 Favors hypochlorous acid Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Panatto (RCT) 29% 0.71 [0.54-0.93] viral+ 34 (n) 15 (n) Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.012 Early treatment 29% 0.71 [0.54-0.93] 34 (n) 15 (n) 29% lower risk All studies 29% 0.71 [0.54-0.93] 34 (n) 15 (n) 29% lower risk 1 hypochlorous acid COVID-19 viral clearance result c19early.org January 2026 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.012 Favors hypochlorous acid Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Delgado-En.. (RCT) 28% 0.72 [0.65-0.79] recovery 35 (n) 104 (n) Improvement, RR [CI] Treatment Control Panatto (RCT) 37% 0.63 [0.12-3.38] progression 2/20 3/19 Tau​2​ = 0.00, I​2​ = 0.0%, p < 0.0001 Early treatment 28% 0.72 [0.65-0.79] 2/55 3/123 28% lower risk Gutiérrez-G.. (RCT) 91% 0.09 [0.01-0.72] symp. case 1/84 10/79 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.022 Prophylaxis 91% 0.09 [0.01-0.72] 1/84 10/79 91% lower risk All studies 50% 0.50 [0.19-1.32] 3/139 13/202 50% lower risk 3 hypochlorous acid COVID-19 Randomized Controlled Trials c19early.org January 2026 Tau​2​ = 0.41, I​2​ = 48.1%, p = 0.16 Effect extraction pre-specified(most serious outcome) Favors hypochlorous acid Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Delgado-En.. (RCT) 28% 0.72 [0.65-0.79] recovery 35 (n) 104 (n) Improvement, RR [CI] Treatment Control Panatto (RCT) 37% 0.63 [0.12-3.38] progression 2/20 3/19 Tau​2​ = 0.00, I​2​ = 0.0%, p < 0.0001 Early treatment 28% 0.72 [0.65-0.79] 2/55 3/123 28% lower risk Gutiérrez-G.. (RCT) 91% 0.09 [0.01-0.72] symp. case 1/84 10/79 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.022 Prophylaxis 91% 0.09 [0.01-0.72] 1/84 10/79 91% lower risk All studies 50% 0.50 [0.19-1.32] 3/139 13/202 50% lower risk 3 hypochlorous acid COVID-19 peer reviewed studies c19early.org January 2026 Tau​2​ = 0.41, I​2​ = 48.1%, p = 0.16 Effect extraction pre-specified(most serious outcome) Favors hypochlorous acid Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Delgado-En.. (RCT) 28% 0.72 [0.65-0.79] recovery 35 (n) 104 (n) Improvement, RR [CI] Treatment Control Delgado-En.. (RCT) 34% 0.66 [0.59-0.75] recovery 35 (n) 104 (n) Delgado-En.. (RCT) 42% 0.58 [0.50-0.68] recovery 35 (n) 104 (n) Delgado-En.. (RCT) 38% 0.62 [0.54-0.71] recovery 35 (n) 104 (n) Delgado-En.. (RCT) 48% 0.52 [0.43-0.63] recovery 35 (n) 104 (n) Delgado-En.. (RCT) 45% 0.55 [0.47-0.66] recovery 35 (n) 104 (n) Delgado-En.. (RCT) 51% 0.49 [0.39-0.60] recovery 35 (n) 104 (n) Panatto (RCT) 37% 0.63 [0.12-3.38] progression 2/20 3/19 Panatto (RCT) 85% 0.15 [0.01-2.65] progression 0/18 3/19 Panatto (RCT) 67% 0.33 [0.06-1.83] progression 2/38 3/19 Panatto (RCT) 29% 0.71 [0.54-0.93] viral+ 34 (n) 15 (n) Panatto (RCT) 30% 0.70 [0.56-0.88] viral+ 34 (n) 15 (n) Gutiérrez-G.. (RCT) 91% 0.09 [0.01-0.72] symp. case 1/84 10/79 Hypochlorous acid COVID-19 outcomes c19early.org January 2026 Favors hypochlorous acid Favors control