Safety and efficacy of a COVID‑19 treatment with nebulized and/or intravenous neutral electrolyzed saline combined with usual medical care vs. usual medical care alone: A randomized, open‑label, controlled trial
Ivan Delgado‑enciso, Juan Paz‑garcia, Carlos Barajas‑saucedo, Karen Mokay‑ramírez, Carmen Meza‑robles, Rodrigo Lopez‑flores, Marina Delgado‑machuca, Efren Murillo‑zamora, Jose Toscano‑velazquez, Josuel Delgado‑enciso, Valery Melnikov, Mireya Walle‑guillen, Hector Galvan‑salazar, Osiris Delgado‑enciso, Ariana Cabrera‑licona, Eduardo Danielewicz‑mata, Pablo Mandujano‑diaz, José Guzman‑esquivel, Daniel Montes‑galindo, Henry Perez‑martinez, Jesus Jimenez‑villegaz, Alejandra Hernandez‑rangel, Patricia Montes‑diaz, Iram Rodriguez‑sanchez, Margarita Martinez‑fierro, Idalia Garza‑veloz, Daniel Tiburcio‑jimenez, Sergio Zaizar‑fregoso, Fidadelfo Gonzalez‑alcaraz, Laydi Gutierrez‑gutierrez, Luciano Diaz‑lopez, Mario Ramirez‑flores, Hannah Guzman‑solorzano, Gustavo Gaytan‑sandoval, Carlos Martinez‑perez, Francisco Espinoza‑gómez, Fabián Rojas‑iarios, Michael Hirsch‑meillon, Luz M Baltazar-Rodriguez, Enrique Barrios‑navarro, Vladimir Oviedo‑rodriguez, Martha Mendoza‑hernandez, Emilio Prieto‑diaz‑chavez, Brenda Paz‑michel
Experimental and Therapeutic Medicine, doi:10.3892/etm.2021.10347
Coronavirus disease 2019 (COVID-19) is currently the major public health problem worldwide. Neutral electrolyzed saline solution that contains reactive chlorine and oxygen species may be an effective therapeutic. In the present study, the treatment efficacy of intravenous and/or nebulized neutral electrolyzed saline combined with usual medical care vs. usual medical care alone was evaluated in ambulatory patients with COVID-19. A prospective, 2-arm, parallel-group, randomized, open-label, multi-center, phase I-II clinical trial including 214 patients was performed. The following two outcomes were evaluated during the 20-day follow-up: i) The number of patients with disease progression; and ii) the patient acceptable symptom state. Serial severe acute respiratory syndrome coronavirus 2 naso/oro-pharyngeal detection by reverse transcription-quantitative (RT-q) PCR was performed in certain patients of the experimental group. Biochemical and hematologic parameters, as well as adverse effects, were also evaluated in the experimental group.
Authors' contributions IDE, JGE, VM and JPG designed the study and wrote the manuscript. IDE, BAPM and JPG conceived the novel application of electrolyzed saline. CEBS, KAMR, CMR, RLF, MDM, EMZ, JATV, OGDE, JDE, MWG, HRGS, PMD, VM, PJMD, HPM, JMJV and LGG visited the ambulatory patients and administered their medication. CEBS, KAMR, DAMG, CMR, JATV, AEHR, IPRS, DTJ, IGV and VOR performed the biochemical and molecular analyses. VM, FEG, FRL, MJHM, JGE, LMBR, SAZF, PJMD, HPM, JMJV, FGA, LDL, HPGS, MAMH and EPDC performed the clinical evaluations of the patients. EBN, MLMF, MRF, GGS, CRMP and IDE designed and performed the statistical analysis. BAPM and ACL coordinated the production and quality control processes of the experimental therapeutic product. EJDM coordinated and authorized the recruitment of patients at the INSABI Poliforum hospital. JDE was the administrative coordinator of the clinical trial. JDE and JGE checked and approved the authenticity of the raw data. All authors read and approved the final manuscript.
Ethics approval and consent to participate The study (registered 2020-01-05) was approved by the ethics committee of the School of Medicine of the Universidad de Colima (Colima, Mexico) and written informed consent was obtained from all participants. All procedures performed in the present protocol were in accordance with the Declaration of Helsinki and the clinical trial was registered as TX-COVID19: RPCEC00000309 in the RPCEC database (05/05/2020).
..
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DOI record:
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"DOI": "10.3892/etm.2021.10347",
"ISSN": [
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