Nasopharyngeal and oropharyngeal rinses with neutral electrolyzed water prevents COVID‑19 in front‑line health professionals: A randomized, open‑label, controlled trial in a general hospital in Mexico City
Rafael Gutiérrez‑garcía, Juan C De La Cerda‑angeles, Ariana Cabrera‑licona, Ivan Delgado‑enciso, Nicolas Mervitch‑sigal, Brenda Paz‑michel
Biomedical Reports, doi:10.3892/br.2021.1494
The worldwide efforts that healthcare professionals are making in the COVID-19 pandemic is well known, and the high risk of illness and death that front-line staff experience on a daily basis is a reality, despite well-defined protocols for the use of personal protective equipment. In addition, it is well known that vaccination is still faraway to be achieved worldwide and that new variants are emerging, thus additional protective measures must be explored. A prospective open-label randomized controlled clinical trial was performed on front-line medical staff from the Dr. Enrique Cabrera General Hospital in México City to evaluate the effectiveness of nasopharyngeal and oropharyngeal rinses with a neutral electrolyzed water, known as SES, to reduce the risk of COVID-19 disease among front-line, not vaccinated medical staff. A total of 170 volunteers were enrolled and equally divided in a control group and SES group. All members of the trial wore the adequate personal protection equipment at all times while performing their duties, as required by standard COVID-19 safety protocols. Additionally, the SES group participants followed a prophylactic protocol with SES (oral and nasal rinses, three times a day for 4 weeks). All participants were monitored for COVID-19 symptoms and disease in a time-frame of 4 weeks and the incidence of illness per group was registered. The relative risk of disease, associated with each treatment was calculated. The presence of COVID-19-positive cases, in the group that received the nasal and oral rinses with SES was 1.2%, while in the group that did not do the SES rinses (control group), it was 12.7% (P=0.0039 and RR=0.09405; 95% CI of 0.01231-0.7183). The prophylactic protocol was demonstrated as a protective factor, in more than 90%, for developing the disease, and without adverse effects. Nasal and oral rinses with SES may be an efficient alternative to reinforce the protective measures against COVID-19 disease and should be further investigated. The present clinical trial was retrospectively registered in the Cuban public registry of clinical trials (RPCEC) database (March 16, 2021; PREVECOVID-19: RPCEC00000357).
Authors' contributions RGG designed the study and conducted the data acquisition. JCDLCA performed the data acquisition. ACL performed the data analysis. IDE performed the data analysis and interpretation. NMS helped with the validation and supply of the neutral electrolyzed water used in the study. RGG, JCA and IDE confirm the authenticity of all the raw data. BAPM participated in the design of the study. All authors helped to prepare, and have read and approved the final manuscript.
Ethics approval and consent to participate The present study was approved by the Research Ethics Committee of the Ministry of Health of Mexico City (Reg. No. 101-010-024-2020) in accordance with the ethical international standards established in the Declaration of Helsinki. Each participant provided their written informed consent, and data was processed according to national and international data protection laws.
Patient consent for publication Not applicable.
Competing interests The authors RGG, JCA and IDE declare that they have no competing interests. ACL, NMS and BPM state that they are employees at Esteripharma S.A. de C.V. company but did not participate in the decision to publish the results of the study, nor in the selection of the volunteers or in its development.
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"subtitle": [],
"title": "Nasopharyngeal and oropharyngeal rinses with neutral electrolyzed water prevents COVID‑19 in front‑line health professionals: A randomized, open‑label, controlled trial in a general hospital in Mexico City",
"type": "journal-article",
"volume": "16"
}
