Outcomes in COVID-19 TRV027 studies

0 0.5 1 1.5+ All studies -54% 2 318 Improvement, Studies, Patients Relative Risk Mortality -54% 2 318 RCTs -54% 2 318 RCT mortality -54% 2 318 Late -54% 2 318 TRV027 for COVID-19 c19early.org December 2025 FavorsTRV027 Favorscontrol
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ COVRAS Robbins (DB RCT) -73% 1.73 [0.18-17.0] death 2/15 1/13 Improvement, RR [CI] Treatment Control ACTIV-4 Self (DB RCT) -52% 1.52 [0.75-3.08] death 145 (n) 145 (n) Tau​2 = 0.00, I​2 = 0.0%, p = 0.21 Late treatment -54% 1.54 [0.78-3.02] 2/160 1/158 54% higher risk All studies -54% 1.54 [0.78-3.02] 2/160 1/158 54% higher risk 2 TRV027 COVID-19 studies c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.21 Effect extraction pre-specified(most serious outcome) Favors TRV027 Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ COVRAS Robbins (DB RCT) -73% 1.73 [0.18-17.0] 2/15 1/13 Improvement, RR [CI] Treatment Control ACTIV-4 Self (DB RCT) -52% 1.52 [0.75-3.08] 145 (n) 145 (n) Tau​2 = 0.00, I​2 = 0.0%, p = 0.21 Late treatment -54% 1.54 [0.78-3.02] 2/160 1/158 54% higher risk All studies -54% 1.54 [0.78-3.02] 2/160 1/158 54% higher risk 2 TRV027 COVID-19 mortality results c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.21 Favors TRV027 Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ COVRAS Robbins (DB RCT) -73% 1.73 [0.18-17.0] death 2/15 1/13 Improvement, RR [CI] Treatment Control ACTIV-4 Self (DB RCT) -52% 1.52 [0.75-3.08] death 145 (n) 145 (n) Tau​2 = 0.00, I​2 = 0.0%, p = 0.21 Late treatment -54% 1.54 [0.78-3.02] 2/160 1/158 54% higher risk All studies -54% 1.54 [0.78-3.02] 2/160 1/158 54% higher risk 2 TRV027 COVID-19 serious outcomes c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.21 Effect extraction pre-specified(most serious outcome) Favors TRV027 Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ ACTIV-4 Self (DB RCT) -35% 1.35 [0.89-2.08] no recov. 145 (n) 145 (n) Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.17 Late treatment -35% 1.35 [0.89-2.08] 145 (n) 145 (n) 35% higher risk All studies -35% 1.35 [0.89-2.08] 145 (n) 145 (n) 35% higher risk 1 TRV027 COVID-19 recovery result c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.17 Favors TRV027 Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ COVRAS Robbins (DB RCT) -73% 1.73 [0.18-17.0] death 2/15 1/13 Improvement, RR [CI] Treatment Control ACTIV-4 Self (DB RCT) -52% 1.52 [0.75-3.08] death 145 (n) 145 (n) Tau​2 = 0.00, I​2 = 0.0%, p = 0.21 Late treatment -54% 1.54 [0.78-3.02] 2/160 1/158 54% higher risk All studies -54% 1.54 [0.78-3.02] 2/160 1/158 54% higher risk 2 TRV027 COVID-19 Randomized Controlled Trials c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.21 Effect extraction pre-specified(most serious outcome) Favors TRV027 Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ COVRAS Robbins (DB RCT) -73% 1.73 [0.18-17.0] 2/15 1/13 Improvement, RR [CI] Treatment Control ACTIV-4 Self (DB RCT) -52% 1.52 [0.75-3.08] 145 (n) 145 (n) Tau​2 = 0.00, I​2 = 0.0%, p = 0.21 Late treatment -54% 1.54 [0.78-3.02] 2/160 1/158 54% higher risk All studies -54% 1.54 [0.78-3.02] 2/160 1/158 54% higher risk 2 TRV027 COVID-19 RCT mortality results c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.21 Favors TRV027 Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ COVRAS Robbins (DB RCT) -73% 1.73 [0.18-17.0] death 2/15 1/13 Improvement, RR [CI] Treatment Control ACTIV-4 Self (DB RCT) -52% 1.52 [0.75-3.08] death 145 (n) 145 (n) Tau​2 = 0.00, I​2 = 0.0%, p = 0.21 Late treatment -54% 1.54 [0.78-3.02] 2/160 1/158 54% higher risk All studies -54% 1.54 [0.78-3.02] 2/160 1/158 54% higher risk 2 TRV027 COVID-19 peer reviewed studies c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.21 Effect extraction pre-specified(most serious outcome) Favors TRV027 Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ COVRAS Robbins (DB RCT) -73% 1.73 [0.18-17.0] death 2/15 1/13 Improvement, RR [CI] Treatment Control ACTIV-4 Self (DB RCT) -52% 1.52 [0.75-3.08] death 145 (n) 145 (n) ACTIV-4 Self (DB RCT) -35% 1.35 [0.89-2.08] no recov. 145 (n) 145 (n) TRV027 COVID-19 outcomes c19early.org December 2025 Favors TRV027 Favors control