Apr 11 2023 |
et al., JAMA, doi:10.1001/jama.2023.3546 | Renin-Angiotensin System Modulation With Synthetic Angiotensin (1-7) and Angiotensin II Type 1 Receptor–Biased Ligand in Adults With COVID-19 |
| 52% higher mortality (p=0.25) and 35% worse recovery (p=0.17). Two RCTs of 510 hospitalized COVID-19 patients showing no significant difference in mortality or days alive without supplemental oxygen with either TRV027 (angiotensin II type 1 receptor-biased ligand) or TXA127 (synthetic angiotensin 1-7.. | ||
Dec 14 2022 |
et al., British Journal of Clinical Pharmacology, doi:10.1111/bcp.15618 | The effect of TRV027 on coagulation in COVID‐19: A pilot randomized, placebo‐controlled trial |
| 73% higher mortality (p=1). Double-blind RCT 30 hospitalized COVID-19 patients in the United Kingdom showing a non-statistically significant trend towards decreased D-dimer levels with TRV027, an angiotensin-(1-7) analogue, compared to placebo. The trial was termina.. | ||
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