Brexanolone: meta-analysis of COVID-19 studies

All studies Mortality Serious outcomes RCTs RCT mortality All outcomes

Outcome (studies)

Improvement

Relative risk · 95% CI

All studies (1)−14%

Mortality (1)−14%

RCTs (1)−14%

Late (1)−14%

00.511.5+

← Brexanolone
reduces riskIncreased
risk →

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c19early.org

October 2026

Brexanolone COVID-19 studies

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Brown (DB RCT)−14%1.14 · 0.57–2.29death8/147/14Ventilated patients

Late treatment−14%1.14 · 0.57–2.298/147/1414% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.72

All studies−14%1.14 · 0.57–2.298/147/1414% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.7200.511.52+

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← Brexanolone
reduces riskBrexanolone
increases risk →

c19early.org

October 2026

Brexanolone COVID-19 mortality results

StudyImprovementRR · 95% CITreatmentControlRelative Risk

Brown (DB RCT)−14%1.14 · 0.57–2.298/147/14Ventilated patients

Late treatment−14%1.14 · 0.57–2.298/147/1414% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.72

All studies−14%1.14 · 0.57–2.298/147/1414% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.7200.511.52+

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← Brexanolone
reduces riskBrexanolone
increases risk →

c19early.org

October 2026

Brexanolone COVID-19 serious outcomes

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Brown (DB RCT)−14%1.14 · 0.57–2.29death8/147/14Ventilated patients

Late treatment−14%1.14 · 0.57–2.298/147/1414% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.72

All studies−14%1.14 · 0.57–2.298/147/1414% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.7200.511.52+

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← Brexanolone
reduces riskBrexanolone
increases risk →

c19early.org

October 2026

Brexanolone COVID-19 Randomized Controlled Trials

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Brown (DB RCT)−14%1.14 · 0.57–2.29death8/147/14Ventilated patients

Late treatment−14%1.14 · 0.57–2.298/147/1414% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.72

All studies−14%1.14 · 0.57–2.298/147/1414% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.7200.511.52+

Rotate screen for more detailsIncrease width for more details

← Brexanolone
reduces riskBrexanolone
increases risk →

c19early.org

October 2026

Brexanolone COVID-19 RCT mortality results

StudyImprovementRR · 95% CITreatmentControlRelative Risk

Brown (DB RCT)−14%1.14 · 0.57–2.298/147/14Ventilated patients

Late treatment−14%1.14 · 0.57–2.298/147/1414% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.72

All studies−14%1.14 · 0.57–2.298/147/1414% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.7200.511.52+

Rotate screen for more detailsIncrease width for more details

← Brexanolone
reduces riskBrexanolone
increases risk →

c19early.org

October 2026

Brexanolone COVID-19 outcomes

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Brown (DB RCT)−14%1.14 · 0.57–2.29death8/147/14Ventilated patients Brown (DB RCT)−33%1.33 · 0.63–2.84death8/146/14Ventilated patients Brown (DB RCT)0%1.00 · 0.63–1.60progression10/1410/14Ventilated patients

00.511.52+

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← Brexanolone
reduces riskBrexanolone
increases risk →