Outcomes in COVID-19 vadadustat studies

All studies   Mortality   Serious outcomes   Recovery   RCTs   RCT mortality   All outcomes  
0 0.5 1 1.5+ All studies -3% 1 448 Improvement, Studies, Patients Relative Risk Mortality -3% 1 448 RCTs -3% 1 448 Late -3% 1 448 Vadadustat for COVID-19 c19early.org December 2025 Favorsvadadustat Favorscontrol
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ VSTAT Bobrow (DB RCT) -3% 1.03 [0.56-1.89] death 19/221 19/227 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.94 Late treatment -3% 1.03 [0.56-1.89] 19/221 19/227 3% higher risk All studies -3% 1.03 [0.56-1.89] 19/221 19/227 3% higher risk 1 vadadustat COVID-19 study c19early.org December 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.94 Effect extraction pre-specified(most serious outcome) Favors vadadustat Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ VSTAT Bobrow (DB RCT) -3% 1.03 [0.56-1.89] 19/221 19/227 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.94 Late treatment -3% 1.03 [0.56-1.89] 19/221 19/227 3% higher risk All studies -3% 1.03 [0.56-1.89] 19/221 19/227 3% higher risk 1 vadadustat COVID-19 mortality result c19early.org December 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.94 Favors vadadustat Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ VSTAT Bobrow (DB RCT) -3% 1.03 [0.56-1.89] death 19/221 19/227 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.94 Late treatment -3% 1.03 [0.56-1.89] 19/221 19/227 3% higher risk All studies -3% 1.03 [0.56-1.89] 19/221 19/227 3% higher risk 1 vadadustat COVID-19 serious outcome c19early.org December 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.94 Effect extraction pre-specified(most serious outcome) Favors vadadustat Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ VSTAT Bobrow (DB RCT) 8% 0.92 [0.68-1.23] no recov. 58/214 66/223 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.58 Late treatment 8% 0.92 [0.68-1.23] 58/214 66/223 8% lower risk All studies 8% 0.92 [0.68-1.23] 58/214 66/223 8% lower risk 1 vadadustat COVID-19 recovery result c19early.org December 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.58 Favors vadadustat Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ VSTAT Bobrow (DB RCT) -3% 1.03 [0.56-1.89] death 19/221 19/227 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.94 Late treatment -3% 1.03 [0.56-1.89] 19/221 19/227 3% higher risk All studies -3% 1.03 [0.56-1.89] 19/221 19/227 3% higher risk 1 vadadustat COVID-19 Randomized Controlled Trial c19early.org December 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.94 Effect extraction pre-specified(most serious outcome) Favors vadadustat Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ VSTAT Bobrow (DB RCT) -3% 1.03 [0.56-1.89] 19/221 19/227 Improvement, RR [CI] Treatment Control Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.94 Late treatment -3% 1.03 [0.56-1.89] 19/221 19/227 3% higher risk All studies -3% 1.03 [0.56-1.89] 19/221 19/227 3% higher risk 1 vadadustat COVID-19 RCT mortality result c19early.org December 2025 Tau​2​ = 0.00, I​2​ = 0.0%, p = 0.94 Favors vadadustat Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ VSTAT Bobrow (DB RCT) -3% 1.03 [0.56-1.89] death 19/221 19/227 Improvement, RR [CI] Treatment Control VSTAT Bobrow (DB RCT) 16% 0.84 [0.59-1.20] progression 43/216 53/223 VSTAT Bobrow (DB RCT) 8% 0.92 [0.68-1.23] no recov. 58/214 66/223 Vadadustat COVID-19 outcomes c19early.org December 2025 Favors vadadustat Favors control