Brequinar: meta-analysis of COVID-19 studies

All studies Hospitalization Serious outcomes RCTs All outcomes

Outcome (studies)

Improvement

Relative risk · 95% CI

All studies (1)−205%

Hospitalization (1)−205%

RCTs (1)−205%

Early (1)−205%

00.511.5+

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October 2026

Brequinar COVID-19 studies

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Powers (DB RCT)−205%3.05 · 0.13–73.43hosp.1/560/59CRISIS2

Early treatment−205%3.05 · 0.13–73.431/560/59205% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.5

All studies−205%3.05 · 0.13–73.431/560/59205% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.500.511.52+

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October 2026

Brequinar COVID-19 hospitalization results

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Powers (DB RCT)−205%3.05 · 0.13–73.43hosp.1/560/59CRISIS2

Early treatment−205%3.05 · 0.13–73.431/560/59205% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.5

All studies−205%3.05 · 0.13–73.431/560/59205% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.500.511.52+

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October 2026

Brequinar COVID-19 serious outcomes

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Powers (DB RCT)−205%3.05 · 0.13–73.43hosp.1/560/59CRISIS2

Early treatment−205%3.05 · 0.13–73.431/560/59205% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.5

All studies−205%3.05 · 0.13–73.431/560/59205% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.500.511.52+

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October 2026

Brequinar COVID-19 Randomized Controlled Trials

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Powers (DB RCT)−205%3.05 · 0.13–73.43hosp.1/560/59CRISIS2

Early treatment−205%3.05 · 0.13–73.431/560/59205% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.5

All studies−205%3.05 · 0.13–73.431/560/59205% higher risk

Tau² = 0.00, I² = 0.0%, p = 0.500.511.52+

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reduces riskBrequinar
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October 2026

Brequinar COVID-19 outcomes

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk

Powers (DB RCT)−205%3.05 · 0.13–73.43hosp.1/560/59CRISIS2

00.511.52+

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reduces riskBrequinar
increases risk →