Outcomes in COVID-19 brequinar studies

0 0.5 1 1.5+ All studies -205% 1 115 Improvement, Studies, Patients Relative Risk Hospitalization -205% 1 115 RCTs -205% 1 115 Early -205% 1 115 Brequinar for COVID-19 c19early.org December 2025 Favorsbrequinar Favorscontrol
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ CRISIS2 Powers (DB RCT) -205% 3.05 [0.13-73.4] hosp. 1/56 0/59 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.5 Early treatment -205% 3.05 [0.13-73.4] 1/56 0/59 205% higher risk All studies -205% 3.05 [0.13-73.4] 1/56 0/59 205% higher risk 1 brequinar COVID-19 study c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.5 Effect extraction pre-specified(most serious outcome) Favors brequinar Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ CRISIS2 Powers (DB RCT) -205% 3.05 [0.13-73.4] hosp. 1/56 0/59 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.5 Early treatment -205% 3.05 [0.13-73.4] 1/56 0/59 205% higher risk All studies -205% 3.05 [0.13-73.4] 1/56 0/59 205% higher risk 1 brequinar COVID-19 hospitalization result c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.5 Favors brequinar Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ CRISIS2 Powers (DB RCT) -205% 3.05 [0.13-73.4] hosp. 1/56 0/59 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.5 Early treatment -205% 3.05 [0.13-73.4] 1/56 0/59 205% higher risk All studies -205% 3.05 [0.13-73.4] 1/56 0/59 205% higher risk 1 brequinar COVID-19 serious outcome c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.5 Effect extraction pre-specified(most serious outcome) Favors brequinar Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ CRISIS2 Powers (DB RCT) -205% 3.05 [0.13-73.4] hosp. 1/56 0/59 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.5 Early treatment -205% 3.05 [0.13-73.4] 1/56 0/59 205% higher risk All studies -205% 3.05 [0.13-73.4] 1/56 0/59 205% higher risk 1 brequinar COVID-19 Randomized Controlled Trial c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.5 Effect extraction pre-specified(most serious outcome) Favors brequinar Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ CRISIS2 Powers (DB RCT) -205% 3.05 [0.13-73.4] hosp. 1/56 0/59 Improvement, RR [CI] Treatment Control Brequinar COVID-19 outcomes c19early.org December 2025 Favors brequinar Favors control