The CRISIS2 Study: A Phase 2, Randomized, Double Blind, Placebo-controlled, Multi-center Study Assessing the Safety and Anti-coronavirus Response of Suppression of Host Nucleotide Synthesis in Out-patient Adults With SARS-CoV-2

Powers et al., NCT04575038, CRISIS2, NCT04575038, Apr 2021
Early treatmentDouble-blind RCT · NCT04575038 · 115 patients · USA
Brequinar for COVID-19
CRISIS2 Powers et al. NCT04575038 · April 2021
Higher hospitalization with brequinar
Not statistically significant · p = 0.49
RCT 115 outpatients in the USA, showing no significant differences with brequinar treatment.
Standard of Care (SOC) for COVID-19 in the study country, the USA, is very poor with very low average efficacy for approved treatments1. Only expensive, high-profit treatments were approved for early treatment. Low-cost treatments were excluded, reducing the probability of early treatment due to access and cost barriers, and eliminating complementary and synergistic benefits seen with many low-cost treatments.
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risk of hospitalization, 205.4% higher, RR 3.05, p = 0.49, treatment 1 of 56 (1.8%), control 0 of 59 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).
viral load, 33.9% higher, relative load 1.34, treatment 34, control 38, mid-recovery, day 8.
viral load, 7.9% lower, relative load 0.92, treatment 38, control 40, day 29.
viral load, 24.1% lower, relative load 0.76, treatment 36, control 39, day 15.
viral load, 13.9% higher, relative load 1.14, treatment 39, control 40, day 4.
time to viral-, 50.0% higher, relative time 1.50, treatment 43, control 45.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Powers et al., 28 Apr 2021, Double Blind Randomized Controlled Trial, placebo-controlled, USA, preprint, 1 author, trial NCT04575038 (history) (CRISIS2). Contact: clinical@clearcreekbio.com.
$0 $500 $1,000+ Efficacy vs. cost for COVID-19 treatment protocols c19early.org October 2026 USA Angola Colombia Kenya Mozambique Myanmar South Africa Peru Philippines Vietnam Japan Argentina Nepal Iran Bangladesh Ethiopia Ghana Germany Mexico South Korea United Kingdom Saudi Arabia Algeria Morocco Yemen Poland Uzbekistan India China Venezuela DR Congo Madagascar Thailand Uganda Egypt Nigeria Taiwan Fiji Zambia Bosnia-Herzegovina Jordan Georgia Switzerland Dominican Republic Bolivia Côte d'Ivoire Eritrea Togo Bulgaria Greece Slovakia Iceland New Zealand Trinidad and Tobago Mongolia Czechia Belarus Israel Haiti North Macedonia Hong Kong Qatar Panama Serbia USA favored high-profit treatments.The average efficacy of treatments was very low.High-cost protocols reduce early treatment, andforgo complementary/synergistic benefits. More effective More expensive 75% 50% 25% ≤0%
$0 $500 $1,000+ Efficacy vs. cost for COVID-19treatment protocols worldwide c19early.org October 2026 USA Angola Colombia Kenya Mozambique Myanmar South Africa Peru Philippines Vietnam Japan Argentina Nepal Iran Bangladesh Ethiopia Ghana Germany Mexico South Korea United Kingdom Saudi Arabia Algeria Morocco Yemen Poland Uzbekistan India China Venezuela DR Congo Madagascar Thailand Uganda Egypt Taiwan Fiji Zambia Jordan Georgia Switzerland Dominican Rep. Bolivia Côte d'Ivoire Eritrea Togo Sri Lanka Bulgaria Greece Slovakia New Zealand Trinidad and Tobago Mongolia Czechia Belarus Israel North Macedonia Hong Kong Qatar Panama Serbia USA favored high-profit treatments.The average efficacy was very low.High-cost protocols reduce early treatment,and forgo complementary/synergistic benefits. More effective More expensive 75% 50% 25% ≤0%
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