CK0802: meta-analysis of COVID-19 studies

0 0.5 1 1.5+ All studies -8% 1 30 Improvement, Studies, Patients Relative Risk Mortality -8% 1 30 RCTs -8% 1 30 Late -8% 1 30 CK0802 for COVID-19 c19early.org December 2025 FavorsCK0802 Favorscontrol
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Gladstone (DB RCT) -8% 1.08 [0.33-3.57] death 15 (n) 15 (n) Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.91 Late treatment -8% 1.08 [0.33-3.57] 15 (n) 15 (n) 8% higher risk All studies -8% 1.08 [0.33-3.57] 15 (n) 15 (n) 8% higher risk 1 CK0802 COVID-19 study c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.91 Effect extraction pre-specified(most serious outcome) Favors CK0802 Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Gladstone (DB RCT) -8% 1.08 [0.33-3.57] 15 (n) 15 (n) Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.91 Late treatment -8% 1.08 [0.33-3.57] 15 (n) 15 (n) 8% higher risk All studies -8% 1.08 [0.33-3.57] 15 (n) 15 (n) 8% higher risk 1 CK0802 COVID-19 mortality result c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.91 Favors CK0802 Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Gladstone (DB RCT) -8% 1.08 [0.33-3.57] death 15 (n) 15 (n) Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.91 Late treatment -8% 1.08 [0.33-3.57] 15 (n) 15 (n) 8% higher risk All studies -8% 1.08 [0.33-3.57] 15 (n) 15 (n) 8% higher risk 1 CK0802 COVID-19 serious outcome c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.91 Effect extraction pre-specified(most serious outcome) Favors CK0802 Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Gladstone (DB RCT) -8% 1.08 [0.33-3.57] death 15 (n) 15 (n) Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.91 Late treatment -8% 1.08 [0.33-3.57] 15 (n) 15 (n) 8% higher risk All studies -8% 1.08 [0.33-3.57] 15 (n) 15 (n) 8% higher risk 1 CK0802 COVID-19 Randomized Controlled Trial c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.91 Effect extraction pre-specified(most serious outcome) Favors CK0802 Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Gladstone (DB RCT) -8% 1.08 [0.33-3.57] 15 (n) 15 (n) Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.91 Late treatment -8% 1.08 [0.33-3.57] 15 (n) 15 (n) 8% higher risk All studies -8% 1.08 [0.33-3.57] 15 (n) 15 (n) 8% higher risk 1 CK0802 COVID-19 RCT mortality result c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.91 Favors CK0802 Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Gladstone (DB RCT) -8% 1.08 [0.33-3.57] death 15 (n) 15 (n) Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.91 Late treatment -8% 1.08 [0.33-3.57] 15 (n) 15 (n) 8% higher risk All studies -8% 1.08 [0.33-3.57] 15 (n) 15 (n) 8% higher risk 1 CK0802 COVID-19 peer reviewed studies c19early.org December 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.91 Effect extraction pre-specified(most serious outcome) Favors CK0802 Favors control 0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Gladstone (DB RCT) -8% 1.08 [0.33-3.57] death 15 (n) 15 (n) Improvement, RR [CI] Treatment Control Gladstone (DB RCT) -75% 1.75 [0.64-4.75] death 7/15 4/15 Gladstone (DB RCT) 50% 0.50 [0.11-2.33] death 2/15 4/15 Gladstone (DB RCT) -27% 1.27 [0.72-2.23] death/int. 15 (n) 15 (n) Gladstone (DB RCT) -50% 1.50 [0.71-3.16] death/int. 9/15 6/15 Gladstone (DB RCT) 0% 1.00 [0.42-2.40] death/int. 6/15 6/15 CK0802 COVID-19 outcomes c19early.org December 2025 Favors CK0802 Favors control