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Hypochlorous Acid for COVID-19
3 studies with 341 patients
Serious outcome risk
Hypochlorous Acid
Control
Significantly lower risk for recovery, cases, and viral clearance.
3 studies from 3 independent teams in 2 countries show significant benefit.
COVID-19 Hypochlorous Acid studies · October 2026
Recent:
Mueller.
Covid Analysis Hypochlorous Acid for COVID-19: real-time meta-analysis of 3 studies
Significantly lower risk is seen for recovery, cases, and viral clearance. 3 studies from 3 independent teams in 2 countries show significant benefit. Meta-analysis using the most serious outcome reported shows 50% [-32‑81%] lo..
Sep 7
2025
 Winter et al., Viruses, doi:10.3390/v17091219 Hypochlorous Acid (HOCl) as a Promising Respiratory Antiseptic
Review of hypochlorous acid (HOCl) as a promising respiratory antiseptic for COVID-19 and other viral infections. Authors propose that aerosolized HOCl solutions up to 500 µM (≈26 ppm) could provide an effective early treatment strategy f..
Aug 1
2025
 Pecoraro et al., Medicina, doi:10.3390/medicina61081402 Nasal Irrigations: A 360-Degree View in Clinical Practice
Review of nasal irrigation as a safe, effective, and low-cost treatment for various upper respiratory conditions. High-volume, low-pressure saline irrigations are effective for removing infectious agents, allergens, and inflammatory media..
Oct 19
2023
 Dianty et al., Frontiers in Microbiology, doi:10.3389/fmicb.2023.1284274 Electrolyzed hypochlorous acid water exhibits potent disinfectant activity against various viruses through irreversible protein aggregation
In vitro study showing that highly purified slightly acidic hypochlorous acid water (Hp-SA-HAW) exhibits broad-spectrum antiviral activity against various viruses including SARS-CoV-2 through irreversible viral protein aggregation.
Jun 12
2023
 Ting et al., Biomedicines, doi:10.3390/biomedicines11061694 Preprocedural Viral Load Effects of Oral Antiseptics on SARS-CoV-2 in Patients with COVID-19: A Systematic Review
Systematic review of 14 RCTs, showing significant reductions in short-term viral load with mouth rinses cetylpyridinium chloride, β-cyclodextrin and citrox, hydrogen peroxide, chlorhexidine, povidone-iodine, hypochlorous acid, saline, and..
Mar 27
2023
 Boecker et al., German Medical Science GMS Publishing House, doi:10.3205/dgkh000433 Antimicrobial efficacy, mode of action and in vivo use of hypochlorous acid (HOCl) for prevention or therapeutic support of infections
Review of hypochlorous acid (HOCl) for in vivo antimicrobial applications including COVID-19. Authors describe HOCl as a naturally occurring component of the innate immune system produced by neutrophils, with broad-spectrum antimicrobial ..
Feb 18
2023
 Tazawa et al., BMC Oral Health, doi:10.1186/s12903-023-02820-7 Hypochlorous acid inactivates oral pathogens and a SARS-CoV-2-surrogate
In vitro study showing that hypochlorous acid (HOCl) effectively inactivates oral pathogens and a SARS-CoV-2 surrogate virus (MHV-A59).
Jul 31
2022
 Ting et al., International Journal of Translational Medicine, doi:10.3390/ijtm2030030 The In Vitro Virucidal Effects of Mouthwashes on SARS-CoV-2
Review of in vitro studies of mouthwashes, showing antiviral activity for SARS-CoV-2 with many compounds including PVP-I, cetylpyridinium chloride, chlorohexidine gluconate, dequalinium chloride, benzalkonium chloride, anionic phthalocyan..
Jul 29
2022
 Sevinç Gül et al., Dental and Medical Problems, doi:10.17219/dmp/150831 Effect of oral antiseptics on the viral load of SARS-CoV-2: A randomized controlled trial
RCT with 21 PVP-I, 20 HOCl, and 20 saline patients gargling for 30 seconds and testing PCR Ct after 30 minutes, showing greater improvement with PVP-I and HOCl, without statistical significance. Ct values differ across testing platforms, ..
May 12
2022
 Panatto et al., Viruses, doi:10.3390/v14051033 Efficacy of the Sentinox Spray in Reducing Viral Load in Mild COVID-19 and Its Virucidal Activity against Other Respiratory Viruses: Results of a Randomized Controlled Trial and an In Vitro Study
29% improved viral clearance (p=0.01). RCT 57 mild COVID-19 patients showing non-significant viral load reduction with Sentinox (STX), a hypochlorous acid nasal spray. The proportion of COVID negative patients by day 5 was significantly higher in the STX-3 group than controls...
Dec 15
2021
 Gutiérrez-García et al., Biomedical Reports, doi:10.3892/br.2021.1494 Nasopharyngeal and oropharyngeal rinses with neutral electrolyzed water prevents COVID‑19 in front‑line health professionals: A randomized, open‑label, controlled trial in a general hospital in Mexico City
91% fewer symptomatic cases (p=0.004). RCT 170 front-line healthcare workers in Mexico showing significantly lower COVID-19 cases with neutral electrolyzed water (SES) nasal and oral rinses. Authors hypothesize that SES inactivates viral particles through its oxidizing potenti..
Jun 29
2021
 Delgado-Enciso et al., Experimental and Therapeutic Medicine, doi:10.3892/etm.2021.10347 Safety and efficacy of a COVID‑19 treatment with nebulized and/or intravenous neutral electrolyzed saline combined with usual medical care vs. usual medical care alone: A randomized, open‑label, controlled trial
28% improved recovery (p<0.0001). RCT 214 ambulatory COVID-19 patients showing significant benefit with nebulized and/or intravenous neutral electrolyzed saline. The treatment group had reduced risk of hospitalization, lower mortality, and faster time to an acceptable sym..
Apr 22
2021
 Mueller et al., Drug Research, doi:10.1055/a-1467-5956 A Concept for the Reduction of Mucosal SARS-CoV-2 Load using Hypochloric Acid Solutions
Proposal to use HOCl-containing gargling solutions or nasal irrigation for reducing the transmission of SARS-CoV-2.