Neurological complications of COVID-19
X Dai, X Cao, Q Jiang, B Wu, T Lou, Y Shao, Y Hu, Q Lan
QJM: An International Journal of Medicine, doi:10.1093/qjmed/hcac272
Corona Virus Disease 2019 (COVID-19) has caused several pandemic peaks worldwide due to its high variability and infectiousness, and COVID-19 has become a long-standing global public health problem. There is growing evidence that severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) frequently causes multi-organ injuries and more severe neurological manifestations. Therefore, increased awareness of possible neurological complications is beneficial in preventing and mitigating the impact of long-term sequelae and improving the prognostic outcome of critically ill patients with COVID-19. Here, we review the main pathways of SARS-CoV-2 neuroinvasion and the potential mechanisms causing neurological damage. We also discuss in detail neurological complications, aiming to provide cutting-edge basis for subsequent related basic research and clinical studies of diagnosis and treatment.
Author contributions Xingliang Dai (Conceptualization, Funding acquisition [
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' <jats:p>Corona Virus Disease 2019 (COVID-19) has caused several pandemic peaks '
'worldwide due to its high variability and infectiousness, and COVID-19 has become a '
'long-standing global public health problem. There is growing evidence that severe acute '
'respiratory syndrome coronavirus-2 (SARS-CoV-2) frequently causes multi-organ injuries and '
'more severe neurological manifestations. Therefore, increased awareness of possible '
'neurological complications is beneficial in preventing and mitigating the impact of long-term '
'sequelae and improving the prognostic outcome of critically ill patients with COVID-19. Here, '
'we review the main pathways of SARS-CoV-2 neuroinvasion and the potential mechanisms causing '
'neurological damage. We also discuss in detail neurological complications, aiming to provide '
'cutting-edge basis for subsequent related basic research and clinical studies of diagnosis '
'and treatment.</jats:p>',
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'title': 'Neurological complications of COVID-19',
'prefix': '10.1093',
'volume': '116',
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'given': 'X',
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