Host proviral and antiviral factors for SARS-CoV-2
Lu Lv, Leiliang Zhang
Virus Genes, doi:10.1007/s11262-021-01869-2
Throughout the viral life cycle, interplays between cellular host factors and virus determine the infectious capacity of the virus. The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a great threat to human life and health. Extensive studies identified a number of host proviral and antiviral factors for SARS-CoV-2. In this review, we summarize the current understanding of the interplay between SARS-CoV-2 and cellular factors during virus entry and replication. Our review will highlight the future direction of study on the infection and pathogenesis of SARS-CoV-2, as well as novel therapeutic strategies and effective antiviral targets for COVID-19.
Author contributions LL wrote the manuscript. LZ conceived the work and revised the manuscript. Both authors read and approved the final manuscript.
Conflict of interest The authors declare no conflict of interest.
Informed consent Not applicable. Research involving human participants and/or animals Not applicable.
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