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c19early.org COVID-19 treatment researchSelect treatment..Select..
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Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

COVID-19 treatment efficacy timeline

Azvudine Evusheld Paxlovid Regdanvimab Vitamin B12 Sunlight Phthalocyanine Alkalinization Fluvoxamine Famotidine Aspirin Molnupiravir Quercetin Diet Bamlanivimab/e.. Hydrogen Peroxide Budesonide Probiotics Casirivimab/i.. Sleep Curcumin Povidone-Iodine Nigella Sativa Melatonin Acetaminophen ↑risk Exercise Vitamin D Antiandrogens Vitamin C Colchicine Ivermectin Metformin Zinc HCQ 2020 2021 2022 2023 Pooled outcomes Specific outcome RCT pooled RCT specific Statistically significant ≥10% improvement ≥3 studies c19early.org May 2024 Time when COVID-19 studies showed efficacy
Azvudine Evusheld Paxlovid Regdanvimab Vitamin B12 Sunlight Phthalocyanine Alkalinization Fluvoxamine Famotidine Aspirin Molnupiravir Quercetin Diet Bamlanivimab/e.. Hydrogen Peroxide Budesonide Probiotics Casirivimab/i.. Sleep Curcumin Povidone-Iodine Nigella Sativa Melatonin Acetaminophen ↑risk Exercise Vitamin D Antiandrogens Vitamin C Colchicine Ivermectin Metformin Zinc HCQ 2020 2021 2022 2023 Pooled outcomes Specific outcome RCT pooled RCT specific Statistically significant ≥10% improvement ≥3 studies c19early.org May 2024 Time when COVID-19 studies showed efficacy
The time when studies indicated that treatments were effective, defined as statistically significant improvement of ≥10% from ≥3 studies. 0.6% of 7,600 proposed treatments have been identified as effective. Results reflect conditions as used in trials to date and depend on many factors including the population treated, treatment delay, and treatment regimen. Click the treatment name to see all studies, where the name of each study can be clicked on for the source paper. No treatment is 100% effective. Protocols typically combine multiple treatments which may be complementary and synergistic. Treatment efficacy may vary by variant, especially for monoclonal antibodies. All treatments have potential side effects which may exceed benefits. All practical, effective, and safe means should be used based on risk/benefit analysis. Submit Corrections or Updates
Currently, 44 of the treatments we analyze show statistically significant efficacy or harm, defined as ≥10% decreased risk or >0% increased risk from ≥3 studies.
RCT confirmation adds 7.0+ months delay. Of the 44 treatments with statistically significant efficacy/harm, 28 have been confirmed in RCTs, with a mean delay of 7.0 months. When considering only low cost treatments, 23 have been confirmed with a delay of 8.4 months. For the 16 unconfirmed treatments, 3 have zero RCTs to date. The point estimates for the remaining 13 are all consistent with the overall results (benefit or harm), with 10 showing >20%. The only treatments showing >10% efficacy for all studies, but <10% for RCTs are sotrovimab and aspirin.
Specific outcome confirmation adds 4.9+ months delay. 90% of treatments showing statistically significant efficacy/harm with pooled effects have been confirmed with one or more specific outcomes, with a mean delay of 4.9 months.
Specific outcome confirmation for RCTs adds 5.5+ months delay. When restricting to RCTs only, 54% of treatments showing statistically significant efficacy/harm with pooled effects have been confirmed with one or more specific outcomes, with a mean delay of 5.5 months.
Pooled outcome analysis with the most serious outcome reported
Specific outcome analysis
Pooled outcome analysis for RCTs only
Specific outcome analysis for RCTs only
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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Thanks for your feedback! Please search before submitting papers and note that studies are listed under the date they were first available, which may be the date of an earlier preprint.
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