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c19early.org COVID-19 treatment researchSelect treatment..Select..
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta
Cannabidiol Meta Molnupiravir Meta
Colchicine Meta
Conv. Plasma Meta
Curcumin Meta Nigella Sativa Meta
Ensovibep Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Peg.. Lambda Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Ivermectin Meta
Lactoferrin Meta

COVID-19 treatment efficacy timeline

Evusheld Paxlovid Alkalinization Phthalocyanine Fluvoxamine Famotidine Molnupiravir Quercetin Bamlanivimab/e.. Hydrogen Peroxide Budesonide Aspirin Probiotics Casirivimab/i.. Curcumin Povidone-Iodine Nigella Sativa Melatonin Acetaminophen ↑risk Vitamin D Vitamin C Colchicine Antiandrogens Ivermectin Metformin Zinc HCQ 2020 2021 2022 2023 Pooled outcomes Specific outcome RCT pooled RCT specific Statistically significant ≥10% improvement ≥3 studies c19early.org Sep 2023 Time when COVID-19 studies showed efficacy
Evusheld Paxlovid Alkalinization Phthalocyanine Fluvoxamine Famotidine Molnupiravir Quercetin Bamlanivimab/e.. Hydrogen Peroxide Budesonide Aspirin Probiotics Casirivimab/i.. Curcumin Povidone-Iodine Nigella Sativa Melatonin Acetaminophen ↑risk Vitamin D Vitamin C Colchicine Antiandrogens Ivermectin Metformin Zinc HCQ 2020 2021 2022 2023 Pooled outcomes Specific outcome RCT pooled RCT specific Statistically significant ≥10% improvement ≥3 studies c19early.org Sep 2023 Time when COVID-19 studies showed efficacy
The time when studies indicated that treatments were effective, defined as statistically significant improvement of ≥10% from ≥3 studies. 0.7% of 5,018 proposed treatments have been identified as effective. Results reflect conditions as used in trials to date and depend on many factors including the population treated, treatment delay, and treatment regimen. Click the treatment name to see all studies, where the name of each study can be clicked on for the source paper. No treatment is 100% effective. Protocols typically combine multiple treatments which may be complementary and synergistic. Treatment efficacy may vary by variant, especially for monoclonal antibodies. All treatments have potential side effects which may exceed benefits. All practical, effective, and safe means should be used based on risk/benefit analysis. Submit Corrections or Updates
Currently, 38 of the treatments we analyze show statistically significant efficacy or harm, defined as ≥10% decreased risk or >0% increased risk from ≥3 studies.
RCT confirmation adds 5.7+ months delay. Of the 38 treatments with statistically significant efficacy/harm, 24 have been confirmed in RCTs, with a mean delay of 5.7 months. For the 14 unconfirmed treatments, 4 have zero RCTs to date. The point estimates for the remaining 10 are all consistent with the overall results (benefit or harm), with 8 showing >20%. The only treatments showing >10% efficacy for all studies, but <10% for RCTs are sotrovimab and aspirin.
Specific outcome confirmation adds 3.3+ months delay. 91% of treatments showing statistically significant efficacy/harm with pooled effects have been confirmed with one or more specific outcomes, with a mean delay of 3.3 months.
Specific outcome confirmation for RCTs adds 3.9+ months delay. When restricting to RCTs only, 57% of treatments showing statistically significant efficacy/harm with pooled effects have been confirmed with one or more specific outcomes, with a mean delay of 3.9 months.
Pooled outcome analysis with the most serious outcome reported
Specific outcome analysis
Pooled outcome analysis for RCTs only
Specific outcome analysis for RCTs only
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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Thanks for your feedback! Please search before submitting papers and note that studies are listed under the date they were first available, which may be the date of an earlier preprint.
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