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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Recovery, dyspnea 42% Improvement Relative Risk Recovery, D+NS, dyspnea 89% Recovery, cough 52% Recovery, D+NS, cough 77% Recovery, fatigue 56% Recovery, D+NS, fatigue 90% Recovery, smell 33% Recovery, D+NS, smell 67% Recovery, taste -25% Recovery, D+NS, taste 58% Recovery, sore throat 56% Recovery, D+NS, sore thr.. 86% Recovery, headache -175% Recovery, D+NS, headache 56% Recovery, diarrhea 87% Recovery, D+NS, diarrhea 90% Viral clearance, day 14 49% Viral clearance, day 7 23% Viral clearance, D+NS, d.. 91% Viral clearance, D+N.. (b) 87% c19early.org/d Said et al. NCT04981743 Vitamin D RCT EARLY TREATMENT Favors vitamin D Favors control
The effect of Nigella sativa and vitamin D3 supplementation on the clinical outcome in COVID-19 patients: A randomized controlled clinical trial
Said et al., Frontiers in Pharmacology, doi:10.3389/fphar.2022.1011522, NCT04981743 (history)
8 Nov 2022    Source   PDF   Share   Tweet
120 patient RCT comparing vitamin D, nigella sativa, and combined vitamin D+nigella sativa, showing improved symptom recovery and viral clearance with both vitamin D and nigella sativa, and further improvements with the combination of both. All patients received vitamin C, zinc, and lactoferrin.
risk of no recovery, 42.0% lower, OR 0.58, p = 0.57, treatment 30, control 30, adjusted per study, multivariable, dyspnea, RR approximated with OR.
risk of no recovery, 89.0% lower, OR 0.11, p = 0.01, treatment 30, control 30, adjusted per study, vitamin D and nigella sativa, multivariable, dyspnea, RR approximated with OR.
risk of no recovery, 52.0% lower, OR 0.48, p = 0.16, treatment 30, control 30, adjusted per study, multivariable, cough, RR approximated with OR.
risk of no recovery, 77.0% lower, OR 0.23, p = 0.01, treatment 30, control 30, adjusted per study, vitamin D and nigella sativa, multivariable, cough, RR approximated with OR.
risk of no recovery, 56.0% lower, OR 0.44, p = 0.20, treatment 30, control 30, adjusted per study, multivariable, fatigue, RR approximated with OR.
risk of no recovery, 90.0% lower, OR 0.10, p < 0.001, treatment 30, control 30, adjusted per study, vitamin D and nigella sativa, multivariable, fatigue, RR approximated with OR.
risk of no recovery, 33.0% lower, OR 0.67, p = 0.67, treatment 30, control 30, adjusted per study, multivariable, smell, RR approximated with OR.
risk of no recovery, 67.0% lower, OR 0.33, p = 0.23, treatment 30, control 30, adjusted per study, vitamin D and nigella sativa, multivariable, smell, RR approximated with OR.
risk of no recovery, 25.0% higher, OR 1.25, p = 0.79, treatment 30, control 30, adjusted per study, multivariable, taste, RR approximated with OR.
risk of no recovery, 58.0% lower, OR 0.42, p = 0.28, treatment 30, control 30, adjusted per study, vitamin D and nigella sativa, multivariable, taste, RR approximated with OR.
risk of no recovery, 56.0% lower, OR 0.44, p = 0.36, treatment 30, control 30, adjusted per study, multivariable, sore throat, RR approximated with OR.
risk of no recovery, 86.0% lower, OR 0.14, p = 0.03, treatment 30, control 30, adjusted per study, vitamin D and nigella sativa, multivariable, sore throat, RR approximated with OR.
risk of no recovery, 175.0% higher, OR 2.75, p = 0.13, treatment 30, control 30, adjusted per study, multivariable, headache, RR approximated with OR.
risk of no recovery, 56.0% lower, OR 0.44, p = 0.21, treatment 30, control 30, adjusted per study, vitamin D and nigella sativa, multivariable, headache, RR approximated with OR.
risk of no recovery, 87.0% lower, OR 0.13, p = 0.07, treatment 30, control 30, adjusted per study, multivariable, diarrhea, RR approximated with OR.
risk of no recovery, 90.0% lower, OR 0.10, p = 0.03, treatment 30, control 30, adjusted per study, vitamin D and nigella sativa, multivariable, diarrhea, RR approximated with OR.
risk of no viral clearance, 49.0% lower, OR 0.51, p = 0.20, treatment 30, control 30, day 14, RR approximated with OR.
risk of no viral clearance, 23.0% lower, OR 0.77, p = 0.74, treatment 30, control 30, day 7, RR approximated with OR.
risk of no viral clearance, 91.0% lower, OR 0.09, p < 0.001, treatment 30, control 30, vitamin D and nigella sativa, day 14, RR approximated with OR.
risk of no viral clearance, 87.0% lower, OR 0.13, p = 0.003, treatment 30, control 30, vitamin D and nigella sativa, day 7, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Said et al., 8 Nov 2022, Randomized Controlled Trial, Egypt, peer-reviewed, 5 authors, dosage 2,000IU daily, trial NCT04981743 (history).
Contact: nagwa.sabri@pharma.asu.edu.eg.
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