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0 0.5 1 1.5 2+ Hospitalization 75% Improvement Relative Risk Recovery 43% Nigella Sativa  Koshak et al.  EARLY TREATMENT  RCT Is early treatment with nigella sativa beneficial for COVID-19? RCT 183 patients in Saudi Arabia (May - September 2020) Improved recovery with nigella sativa (p=0.00021) Koshak et al., Complementary Therapies.., Aug 2021 Favors nigella sativa Favors control

Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial

Koshak et al., Complementary Therapies in Medicine, doi:10.1016/j.ctim.2021.102769, NCT04401202
Aug 2021  
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11th treatment shown to reduce risk in January 2021
*, now known with p = 0.00016 from 14 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
RCT 183 mild COVID-19 outpatients in Saudi Arabia, 91 treated with Nigella Sativa, showing lower hospitalization and faster recovery with treatment. 500mg Nigella Sativa oil (MARNYS Cuminmar) twice daily for 10 days. NCT04401202 (history).
risk of hospitalization, 74.7% lower, RR 0.25, p = 0.37, treatment 1 of 91 (1.1%), control 4 of 92 (4.3%), NNT 31.
risk of no recovery, 42.7% lower, RR 0.57, p < 0.001, treatment 34 of 91 (37.4%), control 60 of 92 (65.2%), NNT 3.6.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Koshak et al., 15 Aug 2021, Randomized Controlled Trial, Saudi Arabia, peer-reviewed, 10 authors, study period 1 May, 2020 - 30 September, 2020, trial NCT04401202 (history).
This PaperNigella SativaAll
Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial
Abdulrahman E Koshak, Emad A Koshak, Abdullah F Mobeireek, Mazen A Badawi, Siraj O Wali, Husam M Malibary, Ali F Atwah, Meshari M Alhamdan, Reem A Almalki, Tariq A Madani
Complementary Therapies in Medicine, doi:10.1016/j.ctim.2021.102769
Background: Effective treatment for Coronavirus Disease-2019 (COVID-19) is under intensive research. Nigella sativa oil (NSO) is a herbal medicine with antiviral and immunomodulatory activities, and has been recommended for the treatment of COVID-19. This study aimed to evaluate the efficacy of NSO treatment in patients with COVID-19. Methods: All adult patients with mild COVID-19 symptoms presented to King
Declaration of Competing Interest The authors report no declarations of interest. Appendix A. Supplementary data Supplementary material related to this article can be found, in the online version, at doi:
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Ms, The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa, J Ethnopharmacol, doi:10.1016/S0378-8741(01)00216-1
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