Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial

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of herbal medicines as adjuvant ' 'symptomatic therapy?', 'volume': '11', 'author': 'Silveira', 'year': '2020', 'journal-title': 'Front Pharmacol'}, { 'issue': 'May', 'key': '10.1016/j.ctim.2021.102769_bib0050', 'article-title': 'Potential role of Nigella sativa supplementation with physical activity ' 'in prophylaxis and treatment of COVID-19: a contemporary review', 'author': 'Shirvani', 'year': '2021', 'journal-title': 'Sport Sci Health'}, { 'issue': '1', 'key': '10.1016/j.ctim.2021.102769_bib0055', 'doi-asserted-by': 'crossref', 'first-page': '696', 'DOI': '10.1080/13880209.2021.1931353', 'article-title': 'Possible therapeutic effects of Nigella sativa and its thymoquinone on ' 'COVID-19', 'volume': '59', 'author': 'Khazdair', 'year': '2021', 'journal-title': 'Pharm Biol'}, { 'issue': '5', 'key': '10.1016/j.ctim.2021.102769_bib0060', 'doi-asserted-by': 'crossref', 'first-page': '337', 'DOI': '10.1016/S2221-1691(13)60075-1', 'article-title': 'A review on therapeutic potential of Nigella sativa: a miracle herb', 'volume': '3', 'author': 'Ahmad', 'year': '2013', 'journal-title': 'Asian Pac J Trop Biomed'}, { 'issue': 'January', 'key': '10.1016/j.ctim.2021.102769_bib0065', 'article-title': 'Nigella sativa supplementation improves asthma control and biomarkers: ' 'a randomized, double-blind, placebo-controlled trial', 'author': 'Koshak', 'year': '2017', 'journal-title': 'Phyther Res'}, { 'key': '10.1016/j.ctim.2021.102769_bib0070', 'doi-asserted-by': 'crossref', 'first-page': '104767', 'DOI': '10.1016/j.phrs.2020.104767', 'article-title': 'The effect of Nigella sativa on the measures of liver and kidney ' 'parameters: a systematic review and meta-analysis of ' 'randomized-controlled trials', 'volume': '156', 'author': 'Razmpoosh', 'year': '2020', 'journal-title': 'Pharmacol Res'}, { 'key': '10.1016/j.ctim.2021.102769_bib0075', 'first-page': '47', 'article-title': 'A review on antiviral effects of Nigella Sativa L', 'volume': '2', 'author': 'Molla', 'year': '2019', 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'10.1016/j.ctim.2021.102769_bib0105', 'first-page': '332', 'article-title': 'Nigella sativa concoction induced sustained seroreversion in HIV ' 'patient', 'volume': '10', 'author': 'Onifade', 'year': '2013', 'journal-title': 'Afr J Tradit Complement Altern Med'}, { 'issue': '3', 'key': '10.1016/j.ctim.2021.102769_bib0110', 'doi-asserted-by': 'crossref', 'first-page': '99', 'DOI': '10.1016/j.hermed.2013.04.006', 'article-title': 'Effectiveness of a herbal remedy in six HIV patients in Nigeria', 'volume': '3', 'author': 'Onifade', 'year': '2013', 'journal-title': 'J Herb Med'}, { 'issue': '16', 'key': '10.1016/j.ctim.2021.102769_bib0115', 'doi-asserted-by': 'crossref', 'first-page': '2529', 'DOI': '10.3748/wjg.v19.i16.2529', 'article-title': 'Effects of Nigella sativa on outcome of hepatitis C in Egypt', 'volume': '19', 'author': 'Barakat', 'year': '2013', 'journal-title': 'World J Gastroenterol'}, { 'key': '10.1016/j.ctim.2021.102769_bib0120', 'doi-asserted-by': 'crossref', 'first-page': '100602', 'DOI': '10.1016/j.curtheres.2020.100602', 'article-title': 'Nigella sativa L as a potential phytotherapy for coronavirus disease ' '2019: a mini review of in silico studies', 'volume': '93', 'author': 'Koshak', 'year': '2020', 'journal-title': 'Curr Ther Res - Clin Exp'}, { 'issue': '10', 'key': '10.1016/j.ctim.2021.102769_bib0125', 'doi-asserted-by': 'crossref', 'first-page': '1298', 'DOI': '10.1080/10408398.2011.633249', 'article-title': 'Immunity: plants as effective mediators', 'volume': '54', 'author': 'Sultan', 'year': '2014', 'journal-title': 'Crit Rev Food Sci Nutr'}, { 'issue': '6', 'key': '10.1016/j.ctim.2021.102769_bib0130', 'first-page': '663', 'article-title': 'Nigella sativa oil as an immunostimulant adjuvant in H5 based DNA ' 'vaccine of H5N1 avian influenza virus', 'volume': '10', 'author': 'Mady', 'year': '2013', 'journal-title': 'Glob Vet'}, { 'issue': '2', 'key': '10.1016/j.ctim.2021.102769_bib0135', 'doi-asserted-by': 'crossref', 'first-page': '147', 'DOI': '10.1016/0162-3109(95)00016-M', 'article-title': 'Nigella sativa: effect on human lymphocytes and polymorphonuclear ' 'leukocyte phagocytic activity', 'volume': '30', 'author': 'Haq', 'year': '1995', 'journal-title': 'Immunopharmacology'}, { 'key': '10.1016/j.ctim.2021.102769_bib0140', 'doi-asserted-by': 'crossref', 'first-page': '437', 'DOI': '10.1186/1472-6882-14-437', 'article-title': 'Effect of Nigella sativa on immune response in treadmill exercised rat', 'volume': '14', 'author': 'Gholamnezhad', 'year': '2014', 'journal-title': 'BMC Complement Altern Med'}, { 'issue': '1', 'key': '10.1016/j.ctim.2021.102769_bib0145', 'doi-asserted-by': 'crossref', 'first-page': '295', 'DOI': '10.1016/j.intimp.2015.06.023', 'article-title': 'Immunomodulatory and anti-inflammatory action of Nigella sativa and ' 'thymoquinone: a comprehensive review', 'volume': '28', 'author': 'Majdalawieh', 'year': '2015', 'journal-title': 'Int Immunopharmacol'}, { 'key': '10.1016/j.ctim.2021.102769_bib0150', 'series-title': 'European Academy of Allergy and Clinical Immunology Congress', 'article-title': 'Comparative anti-inflammatory/immunomodulatory effect of different ' 'extracts of medicinal plant Nigella sativa', 'author': 'Koshak', 'year': '2015'}, { 'issue': '1', 'key': '10.1016/j.ctim.2021.102769_bib0155', 'doi-asserted-by': 'crossref', 'first-page': '45', 'DOI': '10.1016/S0378-8741(01)00216-1', 'article-title': 'The anti-inflammatory, analgesic and antipyretic activity of Nigella ' 'sativa', 'volume': '76', 'author': 'Al-Ghamdi', 'year': '2001', 'journal-title': 'J Ethnopharmacol'}, { 'issue': '3', 'key': '10.1016/j.ctim.2021.102769_bib0160', 'first-page': '115', 'article-title': 'Bronchodilator, spasmolytic and calcium antagonist activities of ' 'Nigella sativa seeds (Kalonji): a traditional herbal product with ' 'multiple medicinal uses', 'volume': '51', 'author': 'Gilani', 'year': '2001', 'journal-title': 'J Pak Med Assoc'}, { 'issue': '5', 'key': '10.1016/j.ctim.2021.102769_bib0165', 'doi-asserted-by': 'crossref', 'first-page': '879', 'DOI': '10.1590/S1807-59322011000500027', 'article-title': 'The effect of Nigella sativa extract on tracheal responsiveness and ' 'lung inflammation in ovalbumin-sensitized guinea pigs', 'volume': '66', 'author': 'Boskabady', 'year': '2011', 'journal-title': 'Clinics'}, { 'issue': '4', 'key': '10.1016/j.ctim.2021.102769_bib0170', 'doi-asserted-by': 'crossref', 'first-page': '474', 'DOI': '10.1002/ddr.21762', 'article-title': 'Review of registered clinical trials for the treatment of COVID-19', 'volume': '82', 'author': 'Babaei', 'year': '2021', 'journal-title': 'Drug Dev Res'}, { 'key': '10.1016/j.ctim.2021.102769_bib0175', 'series-title': 'What are complications of patients with coronavirus disease 2019 ' '(COVID-19)?', 'author': 'Medscape Drugs & Diseases', 'year': '2020'}, { 'key': '10.1016/j.ctim.2021.102769_bib0180', 'series-title': 'ISARIC COVID-19 report: 08 June 2020', 'author': 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