Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial
et al., Complementary Therapies in Medicine, doi:10.1016/j.ctim.2021.102769, NCT04401202 (history)
, Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial, Complementary Therapies in Medicine, doi:10.1016/j.ctim.2021.102769, NCT04401202
RCT 183 mild COVID-19 outpatients in Saudi Arabia, 91 treated with Nigella Sativa, showing lower hospitalization and faster recovery with treatment. 500mg Nigella Sativa oil (MARNYS Cuminmar) twice daily for 10 days. NCT04401202 (history).
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risk of hospitalization, 74.7% lower, RR 0.25, p = 0.37, treatment 1 of 91 (1.1%), control 4 of 92 (4.3%), NNT 31.
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risk of no recovery, 42.7% lower, RR 0.57, p < 0.001, treatment 34 of 91 (37.4%), control 60 of 92 (65.2%), NNT 3.6.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Koshak et al., 15 Aug 2021, Randomized Controlled Trial, Saudi Arabia, peer-reviewed, 10 authors, trial NCT04401202 (history).
Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial
Complementary Therapies in Medicine, doi:10.1016/j.ctim.2021.102769
Background: Effective treatment for Coronavirus Disease-2019 (COVID-19) is under intensive research. Nigella sativa oil (NSO) is a herbal medicine with antiviral and immunomodulatory activities, and has been recommended for the treatment of COVID-19. This study aimed to evaluate the efficacy of NSO treatment in patients with COVID-19. Methods: All adult patients with mild COVID-19 symptoms presented to King
Declaration of Competing Interest The authors report no declarations of interest.
Appendix A. Supplementary data Supplementary material related to this article can be found, in the online version, at doi:https://doi.org/10.1016/j.ctim.2021.102769.
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